Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems
Research output: Contribution to journal › Journal article › peer-review
Standard
Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. / Berbel-Filho, Waldir M.; Pacheco, George; Lira, Mateus G.; de Leaniz, Carlos Garcia; Lima, Sergio M. Q.; Rodríguez-López, Carlos M.; Zhou, Jia; Consuegra, Sofia.
In: Epigenetics, Vol. 17, No. 13, 2022, p. 2356-2365.Research output: Contribution to journal › Journal article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems
AU - Berbel-Filho, Waldir M.
AU - Pacheco, George
AU - Lira, Mateus G.
AU - de Leaniz, Carlos Garcia
AU - Lima, Sergio M. Q.
AU - Rodríguez-López, Carlos M.
AU - Zhou, Jia
AU - Consuegra, Sofia
PY - 2022
Y1 - 2022
N2 - Hybridization is a major source of evolutionary innovation. In plants, epigenetic mechanisms can help to stabilize hybrid genomes and contribute to reproductive isolation, but the relationship between genetic and epigenetic changes in animal hybrids is unclear. We analysed the relationship between genetic background and methylation patterns in natural hybrids of two genetically divergent fish species with different mating systems, Kryptolebias hermaphroditus (self-fertilizing) and K. ocellatus (outcrossing). Co-existing parental species displayed highly distinct genetic (SNPs) and methylation patterns (37,000 differentially methylated cytosines). Hybrids had predominantly intermediate methylation patterns (88.5% of the sites) suggesting additive effects, as expected from hybridization between genetically distant species. The large number of differentially methylated cytosines between hybrids and parental species (n = 5,800) suggests that hybridization may play a role in increasing genetic and epigenetic variation. Although most of the observed epigenetic variation was additive and had a strong genetic component, we also found a small percentage of non-additive, potentially stochastic, methylation differences that might act as an evolutionary bet-hedging strategy and increase fitness under environmental instability.
AB - Hybridization is a major source of evolutionary innovation. In plants, epigenetic mechanisms can help to stabilize hybrid genomes and contribute to reproductive isolation, but the relationship between genetic and epigenetic changes in animal hybrids is unclear. We analysed the relationship between genetic background and methylation patterns in natural hybrids of two genetically divergent fish species with different mating systems, Kryptolebias hermaphroditus (self-fertilizing) and K. ocellatus (outcrossing). Co-existing parental species displayed highly distinct genetic (SNPs) and methylation patterns (37,000 differentially methylated cytosines). Hybrids had predominantly intermediate methylation patterns (88.5% of the sites) suggesting additive effects, as expected from hybridization between genetically distant species. The large number of differentially methylated cytosines between hybrids and parental species (n = 5,800) suggests that hybridization may play a role in increasing genetic and epigenetic variation. Although most of the observed epigenetic variation was additive and had a strong genetic component, we also found a small percentage of non-additive, potentially stochastic, methylation differences that might act as an evolutionary bet-hedging strategy and increase fitness under environmental instability.
KW - DNA methylation
KW - self-fertilization
KW - outcrossing
KW - epigenetic diversity
KW - mangrove killifish
KW - GENE-EXPRESSION
KW - INTERSPECIFIC HYBRIDIZATION
KW - MANGROVE KILLIFISHES
KW - CYTOSINE METHYLATION
KW - HYBRID
KW - TRANSCRIPTOME
KW - CONSEQUENCES
KW - PATTERNS
KW - INSIGHTS
KW - PLANTS
U2 - 10.1080/15592294.2022.2123014
DO - 10.1080/15592294.2022.2123014
M3 - Journal article
C2 - 36082413
VL - 17
SP - 2356
EP - 2365
JO - Epigenetics
JF - Epigenetics
SN - 1559-2294
IS - 13
ER -
ID: 320116366