Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems

Research output: Contribution to journalJournal articlepeer-review

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Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. / Berbel-Filho, Waldir M.; Pacheco, George; Lira, Mateus G.; de Leaniz, Carlos Garcia; Lima, Sergio M. Q.; Rodríguez-López, Carlos M.; Zhou, Jia; Consuegra, Sofia.

In: Epigenetics, Vol. 17, No. 13, 2022, p. 2356-2365.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Berbel-Filho, WM, Pacheco, G, Lira, MG, de Leaniz, CG, Lima, SMQ, Rodríguez-López, CM, Zhou, J & Consuegra, S 2022, 'Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems', Epigenetics, vol. 17, no. 13, pp. 2356-2365. https://doi.org/10.1080/15592294.2022.2123014

APA

Berbel-Filho, W. M., Pacheco, G., Lira, M. G., de Leaniz, C. G., Lima, S. M. Q., Rodríguez-López, C. M., Zhou, J., & Consuegra, S. (2022). Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. Epigenetics, 17(13), 2356-2365. https://doi.org/10.1080/15592294.2022.2123014

Vancouver

Berbel-Filho WM, Pacheco G, Lira MG, de Leaniz CG, Lima SMQ, Rodríguez-López CM et al. Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. Epigenetics. 2022;17(13):2356-2365. https://doi.org/10.1080/15592294.2022.2123014

Author

Berbel-Filho, Waldir M. ; Pacheco, George ; Lira, Mateus G. ; de Leaniz, Carlos Garcia ; Lima, Sergio M. Q. ; Rodríguez-López, Carlos M. ; Zhou, Jia ; Consuegra, Sofia. / Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. In: Epigenetics. 2022 ; Vol. 17, No. 13. pp. 2356-2365.

Bibtex

@article{a6036b1fa2d04c449f88689c225bdec7,
title = "Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems",
abstract = "Hybridization is a major source of evolutionary innovation. In plants, epigenetic mechanisms can help to stabilize hybrid genomes and contribute to reproductive isolation, but the relationship between genetic and epigenetic changes in animal hybrids is unclear. We analysed the relationship between genetic background and methylation patterns in natural hybrids of two genetically divergent fish species with different mating systems, Kryptolebias hermaphroditus (self-fertilizing) and K. ocellatus (outcrossing). Co-existing parental species displayed highly distinct genetic (SNPs) and methylation patterns (37,000 differentially methylated cytosines). Hybrids had predominantly intermediate methylation patterns (88.5% of the sites) suggesting additive effects, as expected from hybridization between genetically distant species. The large number of differentially methylated cytosines between hybrids and parental species (n = 5,800) suggests that hybridization may play a role in increasing genetic and epigenetic variation. Although most of the observed epigenetic variation was additive and had a strong genetic component, we also found a small percentage of non-additive, potentially stochastic, methylation differences that might act as an evolutionary bet-hedging strategy and increase fitness under environmental instability.",
keywords = "DNA methylation, self-fertilization, outcrossing, epigenetic diversity, mangrove killifish, GENE-EXPRESSION, INTERSPECIFIC HYBRIDIZATION, MANGROVE KILLIFISHES, CYTOSINE METHYLATION, HYBRID, TRANSCRIPTOME, CONSEQUENCES, PATTERNS, INSIGHTS, PLANTS",
author = "Berbel-Filho, {Waldir M.} and George Pacheco and Lira, {Mateus G.} and {de Leaniz}, {Carlos Garcia} and Lima, {Sergio M. Q.} and Rodr{\'i}guez-L{\'o}pez, {Carlos M.} and Jia Zhou and Sofia Consuegra",
year = "2022",
doi = "10.1080/15592294.2022.2123014",
language = "English",
volume = "17",
pages = "2356--2365",
journal = "Epigenetics",
issn = "1559-2294",
publisher = "Taylor & Francis",
number = "13",

}

RIS

TY - JOUR

T1 - Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems

AU - Berbel-Filho, Waldir M.

AU - Pacheco, George

AU - Lira, Mateus G.

AU - de Leaniz, Carlos Garcia

AU - Lima, Sergio M. Q.

AU - Rodríguez-López, Carlos M.

AU - Zhou, Jia

AU - Consuegra, Sofia

PY - 2022

Y1 - 2022

N2 - Hybridization is a major source of evolutionary innovation. In plants, epigenetic mechanisms can help to stabilize hybrid genomes and contribute to reproductive isolation, but the relationship between genetic and epigenetic changes in animal hybrids is unclear. We analysed the relationship between genetic background and methylation patterns in natural hybrids of two genetically divergent fish species with different mating systems, Kryptolebias hermaphroditus (self-fertilizing) and K. ocellatus (outcrossing). Co-existing parental species displayed highly distinct genetic (SNPs) and methylation patterns (37,000 differentially methylated cytosines). Hybrids had predominantly intermediate methylation patterns (88.5% of the sites) suggesting additive effects, as expected from hybridization between genetically distant species. The large number of differentially methylated cytosines between hybrids and parental species (n = 5,800) suggests that hybridization may play a role in increasing genetic and epigenetic variation. Although most of the observed epigenetic variation was additive and had a strong genetic component, we also found a small percentage of non-additive, potentially stochastic, methylation differences that might act as an evolutionary bet-hedging strategy and increase fitness under environmental instability.

AB - Hybridization is a major source of evolutionary innovation. In plants, epigenetic mechanisms can help to stabilize hybrid genomes and contribute to reproductive isolation, but the relationship between genetic and epigenetic changes in animal hybrids is unclear. We analysed the relationship between genetic background and methylation patterns in natural hybrids of two genetically divergent fish species with different mating systems, Kryptolebias hermaphroditus (self-fertilizing) and K. ocellatus (outcrossing). Co-existing parental species displayed highly distinct genetic (SNPs) and methylation patterns (37,000 differentially methylated cytosines). Hybrids had predominantly intermediate methylation patterns (88.5% of the sites) suggesting additive effects, as expected from hybridization between genetically distant species. The large number of differentially methylated cytosines between hybrids and parental species (n = 5,800) suggests that hybridization may play a role in increasing genetic and epigenetic variation. Although most of the observed epigenetic variation was additive and had a strong genetic component, we also found a small percentage of non-additive, potentially stochastic, methylation differences that might act as an evolutionary bet-hedging strategy and increase fitness under environmental instability.

KW - DNA methylation

KW - self-fertilization

KW - outcrossing

KW - epigenetic diversity

KW - mangrove killifish

KW - GENE-EXPRESSION

KW - INTERSPECIFIC HYBRIDIZATION

KW - MANGROVE KILLIFISHES

KW - CYTOSINE METHYLATION

KW - HYBRID

KW - TRANSCRIPTOME

KW - CONSEQUENCES

KW - PATTERNS

KW - INSIGHTS

KW - PLANTS

U2 - 10.1080/15592294.2022.2123014

DO - 10.1080/15592294.2022.2123014

M3 - Journal article

C2 - 36082413

VL - 17

SP - 2356

EP - 2365

JO - Epigenetics

JF - Epigenetics

SN - 1559-2294

IS - 13

ER -

ID: 320116366