Parallel adaptation of rabbit populations to myxoma virus

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Parallel adaptation of rabbit populations to myxoma virus. / Alves, Joel M.; Carneiro, Miguel; Cheng, Jade Y.; Matos, Ana Lemos de; Rahman, Masmudur M.; Loog, Liisa; Campos, Paula F.; Wales, Nathan; Eriksson, Anders; Manica, Andrea; Strive, Tanja; Graham, Stephen C.; Afonso, Sandra; Bell, Diana J.; Belmont, Laura; Day, Jonathan P.; Fuller, Susan J.; Marchandeau, Stéphane; Palmer, William J.; Queney, Guillaume; Surridge, Alison K.; Vieira, Filipe G.; McFadden, Grant; Nielsen, Rasmus; Gilbert, M. Thomas P.; Esteves, Pedro J.; Ferrand, Nuno; Jiggins, Francis M.

In: Science, Vol. 363, No. 6433, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Alves, JM, Carneiro, M, Cheng, JY, Matos, ALD, Rahman, MM, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Afonso, S, Bell, DJ, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, G, Nielsen, R, Gilbert, MTP, Esteves, PJ, Ferrand, N & Jiggins, FM 2019, 'Parallel adaptation of rabbit populations to myxoma virus', Science, vol. 363, no. 6433. https://doi.org/10.1126/science.aau7285

APA

Alves, J. M., Carneiro, M., Cheng, J. Y., Matos, A. L. D., Rahman, M. M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., ... Jiggins, F. M. (2019). Parallel adaptation of rabbit populations to myxoma virus. Science, 363(6433). https://doi.org/10.1126/science.aau7285

Vancouver

Alves JM, Carneiro M, Cheng JY, Matos ALD, Rahman MM, Loog L et al. Parallel adaptation of rabbit populations to myxoma virus. Science. 2019;363(6433). https://doi.org/10.1126/science.aau7285

Author

Alves, Joel M. ; Carneiro, Miguel ; Cheng, Jade Y. ; Matos, Ana Lemos de ; Rahman, Masmudur M. ; Loog, Liisa ; Campos, Paula F. ; Wales, Nathan ; Eriksson, Anders ; Manica, Andrea ; Strive, Tanja ; Graham, Stephen C. ; Afonso, Sandra ; Bell, Diana J. ; Belmont, Laura ; Day, Jonathan P. ; Fuller, Susan J. ; Marchandeau, Stéphane ; Palmer, William J. ; Queney, Guillaume ; Surridge, Alison K. ; Vieira, Filipe G. ; McFadden, Grant ; Nielsen, Rasmus ; Gilbert, M. Thomas P. ; Esteves, Pedro J. ; Ferrand, Nuno ; Jiggins, Francis M. / Parallel adaptation of rabbit populations to myxoma virus. In: Science. 2019 ; Vol. 363, No. 6433.

Bibtex

@article{b5d0511213c848deb4b7569b83a95622,
title = "Parallel adaptation of rabbit populations to myxoma virus",
abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.",
author = "Alves, {Joel M.} and Miguel Carneiro and Cheng, {Jade Y.} and Matos, {Ana Lemos de} and Rahman, {Masmudur M.} and Liisa Loog and Campos, {Paula F.} and Nathan Wales and Anders Eriksson and Andrea Manica and Tanja Strive and Graham, {Stephen C.} and Sandra Afonso and Bell, {Diana J.} and Laura Belmont and Day, {Jonathan P.} and Fuller, {Susan J.} and St{\'e}phane Marchandeau and Palmer, {William J.} and Guillaume Queney and Surridge, {Alison K.} and Vieira, {Filipe G.} and Grant McFadden and Rasmus Nielsen and Gilbert, {M. Thomas P.} and Esteves, {Pedro J.} and Nuno Ferrand and Jiggins, {Francis M.}",
year = "2019",
doi = "10.1126/science.aau7285",
language = "English",
volume = "363",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6433",

}

RIS

TY - JOUR

T1 - Parallel adaptation of rabbit populations to myxoma virus

AU - Alves, Joel M.

AU - Carneiro, Miguel

AU - Cheng, Jade Y.

AU - Matos, Ana Lemos de

AU - Rahman, Masmudur M.

AU - Loog, Liisa

AU - Campos, Paula F.

AU - Wales, Nathan

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Strive, Tanja

AU - Graham, Stephen C.

AU - Afonso, Sandra

AU - Bell, Diana J.

AU - Belmont, Laura

AU - Day, Jonathan P.

AU - Fuller, Susan J.

AU - Marchandeau, Stéphane

AU - Palmer, William J.

AU - Queney, Guillaume

AU - Surridge, Alison K.

AU - Vieira, Filipe G.

AU - McFadden, Grant

AU - Nielsen, Rasmus

AU - Gilbert, M. Thomas P.

AU - Esteves, Pedro J.

AU - Ferrand, Nuno

AU - Jiggins, Francis M.

PY - 2019

Y1 - 2019

N2 - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

AB - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.

U2 - 10.1126/science.aau7285

DO - 10.1126/science.aau7285

M3 - Journal article

C2 - 30765607

AN - SCOPUS:85061759943

VL - 363

JO - Science

JF - Science

SN - 0036-8075

IS - 6433

ER -

ID: 214274810