Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance

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Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance. / Morales, Hernán E.; Pavlova, Alexandra; Joseph, Leo; Sunnucks, Paul.

In: Molecular Ecology, Vol. 24, No. 11, 01.05.2015, p. 2820-2837.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Morales, HE, Pavlova, A, Joseph, L & Sunnucks, P 2015, 'Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance', Molecular Ecology, vol. 24, no. 11, pp. 2820-2837. https://doi.org/10.1111/mec.13203

APA

Morales, H. E., Pavlova, A., Joseph, L., & Sunnucks, P. (2015). Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance. Molecular Ecology, 24(11), 2820-2837. https://doi.org/10.1111/mec.13203

Vancouver

Morales HE, Pavlova A, Joseph L, Sunnucks P. Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance. Molecular Ecology. 2015 May 1;24(11):2820-2837. https://doi.org/10.1111/mec.13203

Author

Morales, Hernán E. ; Pavlova, Alexandra ; Joseph, Leo ; Sunnucks, Paul. / Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance. In: Molecular Ecology. 2015 ; Vol. 24, No. 11. pp. 2820-2837.

Bibtex

@article{1e383ae4cfab404394ac13e1b590fcc7,
title = "Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance",
abstract = "Diversifying selection on metabolic pathways can reduce intraspecific gene flow and promote population divergence. An opportunity to explore this arises from mitonuclear discordance observed in an Australian bird Eopsaltria australis. Across >1500 km, nuclear differentiation is low and latitudinally structured by isolation by distance, whereas two highly divergent, parapatric mitochondrial lineages (>6.6% in ND2) show a discordant longitudinal geographic pattern and experience different climates. Vicari- ance, incomplete lineage sorting and sex-biased dispersal were shown earlier to be unlikely drivers of the mitonuclear discordance; instead, natural selection on a female- linked trait was the preferred hypothesis. Accordingly, here we tested for signals of positive, divergent selection on mitochondrial genes in E. australis. We used codon models and physicochemical profiles of amino acid replacements to analyse complete mitochondrial genomes of the two mitochondrial lineages in E. australis, its sister spe- cies Eopsaltria griseogularis, and outgroups. We found evidence of positive selection on at least five amino acids, encoded by genes of two oxidative phosphorylation path- way complexes NADH dehydrogenase (ND4 and ND4L) and cytochrome bc1 (cyt-b) against a background of widespread purifying selection on all mitochondrial genes. Three of these amino acid replacements were fixed in ND4 of the geographically most widespread E. australis lineage. The other two replacements were fixed in ND4L and cyt-b of the geographically more restricted E. australis lineage. We discuss whether this selection may reflect local environmental adaptation, a by-product of other selec- tive processes, or genetic incompatibilities, and propose how these hypotheses can be tested in future.",
author = "Morales, {Hern{\'a}n E.} and Alexandra Pavlova and Leo Joseph and Paul Sunnucks",
year = "2015",
month = may,
day = "1",
doi = "10.1111/mec.13203",
language = "Udefineret/Ukendt",
volume = "24",
pages = "2820--2837",
journal = "Molecular Ecology",
issn = "0962-1083",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance

AU - Morales, Hernán E.

AU - Pavlova, Alexandra

AU - Joseph, Leo

AU - Sunnucks, Paul

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Diversifying selection on metabolic pathways can reduce intraspecific gene flow and promote population divergence. An opportunity to explore this arises from mitonuclear discordance observed in an Australian bird Eopsaltria australis. Across >1500 km, nuclear differentiation is low and latitudinally structured by isolation by distance, whereas two highly divergent, parapatric mitochondrial lineages (>6.6% in ND2) show a discordant longitudinal geographic pattern and experience different climates. Vicari- ance, incomplete lineage sorting and sex-biased dispersal were shown earlier to be unlikely drivers of the mitonuclear discordance; instead, natural selection on a female- linked trait was the preferred hypothesis. Accordingly, here we tested for signals of positive, divergent selection on mitochondrial genes in E. australis. We used codon models and physicochemical profiles of amino acid replacements to analyse complete mitochondrial genomes of the two mitochondrial lineages in E. australis, its sister spe- cies Eopsaltria griseogularis, and outgroups. We found evidence of positive selection on at least five amino acids, encoded by genes of two oxidative phosphorylation path- way complexes NADH dehydrogenase (ND4 and ND4L) and cytochrome bc1 (cyt-b) against a background of widespread purifying selection on all mitochondrial genes. Three of these amino acid replacements were fixed in ND4 of the geographically most widespread E. australis lineage. The other two replacements were fixed in ND4L and cyt-b of the geographically more restricted E. australis lineage. We discuss whether this selection may reflect local environmental adaptation, a by-product of other selec- tive processes, or genetic incompatibilities, and propose how these hypotheses can be tested in future.

AB - Diversifying selection on metabolic pathways can reduce intraspecific gene flow and promote population divergence. An opportunity to explore this arises from mitonuclear discordance observed in an Australian bird Eopsaltria australis. Across >1500 km, nuclear differentiation is low and latitudinally structured by isolation by distance, whereas two highly divergent, parapatric mitochondrial lineages (>6.6% in ND2) show a discordant longitudinal geographic pattern and experience different climates. Vicari- ance, incomplete lineage sorting and sex-biased dispersal were shown earlier to be unlikely drivers of the mitonuclear discordance; instead, natural selection on a female- linked trait was the preferred hypothesis. Accordingly, here we tested for signals of positive, divergent selection on mitochondrial genes in E. australis. We used codon models and physicochemical profiles of amino acid replacements to analyse complete mitochondrial genomes of the two mitochondrial lineages in E. australis, its sister spe- cies Eopsaltria griseogularis, and outgroups. We found evidence of positive selection on at least five amino acids, encoded by genes of two oxidative phosphorylation path- way complexes NADH dehydrogenase (ND4 and ND4L) and cytochrome bc1 (cyt-b) against a background of widespread purifying selection on all mitochondrial genes. Three of these amino acid replacements were fixed in ND4 of the geographically most widespread E. australis lineage. The other two replacements were fixed in ND4L and cyt-b of the geographically more restricted E. australis lineage. We discuss whether this selection may reflect local environmental adaptation, a by-product of other selec- tive processes, or genetic incompatibilities, and propose how these hypotheses can be tested in future.

U2 - 10.1111/mec.13203

DO - 10.1111/mec.13203

M3 - Tidsskriftartikel

VL - 24

SP - 2820

EP - 2837

JO - Molecular Ecology

JF - Molecular Ecology

SN - 0962-1083

IS - 11

ER -

ID: 246093858