Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens

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Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens. / Barnett, Ross; Westbury, Michael V.; Sandoval-Velasco, Marcela; Vieira, Filipe Garrett; Jeon, Sungwon; Zazula, Grant; Martin, Michael D.; Ho, Simon Y.W.; Mather, Niklas; Gopalakrishnan, Shyam; Ramos-Madrigal, Jazmín; de Manuel, Marc; Zepeda-Mendoza, M. Lisandra; Antunes, Agostinho; Baez, Aldo Carmona; De Cahsan, Binia; Larson, Greger; O’Brien, Stephen J.; Eizirik, Eduardo; Johnson, Warren E.; Koepfli, Klaus-Peter; Wilting, Andreas; Fickel, Jörns; Dalén, Love; Lorenzen, Eline D.; Marques-Bonet, Tomas; Hansen, Anders J.; Zhang, Guojie; Bhak, Jong; Yamaguchi, Nobuyuki; Gilbert, M. Thomas P.

In: Current Biology, Vol. 30, 2020, p. 5018-5025.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Barnett, R, Westbury, MV, Sandoval-Velasco, M, Vieira, FG, Jeon, S, Zazula, G, Martin, MD, Ho, SYW, Mather, N, Gopalakrishnan, S, Ramos-Madrigal, J, de Manuel, M, Zepeda-Mendoza, ML, Antunes, A, Baez, AC, De Cahsan, B, Larson, G, O’Brien, SJ, Eizirik, E, Johnson, WE, Koepfli, K-P, Wilting, A, Fickel, J, Dalén, L, Lorenzen, ED, Marques-Bonet, T, Hansen, AJ, Zhang, G, Bhak, J, Yamaguchi, N & Gilbert, MTP 2020, 'Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens', Current Biology, vol. 30, pp. 5018-5025. https://doi.org/10.1016/j.cub.2020.09.051

APA

Barnett, R., Westbury, M. V., Sandoval-Velasco, M., Vieira, F. G., Jeon, S., Zazula, G., Martin, M. D., Ho, S. Y. W., Mather, N., Gopalakrishnan, S., Ramos-Madrigal, J., de Manuel, M., Zepeda-Mendoza, M. L., Antunes, A., Baez, A. C., De Cahsan, B., Larson, G., O’Brien, S. J., Eizirik, E., ... Gilbert, M. T. P. (2020). Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens. Current Biology, 30, 5018-5025. https://doi.org/10.1016/j.cub.2020.09.051

Vancouver

Barnett R, Westbury MV, Sandoval-Velasco M, Vieira FG, Jeon S, Zazula G et al. Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens. Current Biology. 2020;30:5018-5025. https://doi.org/10.1016/j.cub.2020.09.051

Author

Barnett, Ross ; Westbury, Michael V. ; Sandoval-Velasco, Marcela ; Vieira, Filipe Garrett ; Jeon, Sungwon ; Zazula, Grant ; Martin, Michael D. ; Ho, Simon Y.W. ; Mather, Niklas ; Gopalakrishnan, Shyam ; Ramos-Madrigal, Jazmín ; de Manuel, Marc ; Zepeda-Mendoza, M. Lisandra ; Antunes, Agostinho ; Baez, Aldo Carmona ; De Cahsan, Binia ; Larson, Greger ; O’Brien, Stephen J. ; Eizirik, Eduardo ; Johnson, Warren E. ; Koepfli, Klaus-Peter ; Wilting, Andreas ; Fickel, Jörns ; Dalén, Love ; Lorenzen, Eline D. ; Marques-Bonet, Tomas ; Hansen, Anders J. ; Zhang, Guojie ; Bhak, Jong ; Yamaguchi, Nobuyuki ; Gilbert, M. Thomas P. / Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens. In: Current Biology. 2020 ; Vol. 30. pp. 5018-5025.

Bibtex

@article{68e3bc2d29b847d5982fa2550203ad9c,
title = "Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens",
abstract = "Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1–4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6–8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a7x nuclear genome and a38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11–14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.",
author = "Ross Barnett and Westbury, {Michael V.} and Marcela Sandoval-Velasco and Vieira, {Filipe Garrett} and Sungwon Jeon and Grant Zazula and Martin, {Michael D.} and Ho, {Simon Y.W.} and Niklas Mather and Shyam Gopalakrishnan and Jazm{\'i}n Ramos-Madrigal and {de Manuel}, Marc and Zepeda-Mendoza, {M. Lisandra} and Agostinho Antunes and Baez, {Aldo Carmona} and {De Cahsan}, Binia and Greger Larson and O{\textquoteright}Brien, {Stephen J.} and Eduardo Eizirik and Johnson, {Warren E.} and Klaus-Peter Koepfli and Andreas Wilting and J{\"o}rns Fickel and Love Dal{\'e}n and Lorenzen, {Eline D.} and Tomas Marques-Bonet and Hansen, {Anders J.} and Guojie Zhang and Jong Bhak and Nobuyuki Yamaguchi and Gilbert, {M. Thomas P.}",
year = "2020",
doi = "10.1016/j.cub.2020.09.051",
language = "English",
volume = "30",
pages = "5018--5025",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens

AU - Barnett, Ross

AU - Westbury, Michael V.

AU - Sandoval-Velasco, Marcela

AU - Vieira, Filipe Garrett

AU - Jeon, Sungwon

AU - Zazula, Grant

AU - Martin, Michael D.

AU - Ho, Simon Y.W.

AU - Mather, Niklas

AU - Gopalakrishnan, Shyam

AU - Ramos-Madrigal, Jazmín

AU - de Manuel, Marc

AU - Zepeda-Mendoza, M. Lisandra

AU - Antunes, Agostinho

AU - Baez, Aldo Carmona

AU - De Cahsan, Binia

AU - Larson, Greger

AU - O’Brien, Stephen J.

AU - Eizirik, Eduardo

AU - Johnson, Warren E.

AU - Koepfli, Klaus-Peter

AU - Wilting, Andreas

AU - Fickel, Jörns

AU - Dalén, Love

AU - Lorenzen, Eline D.

AU - Marques-Bonet, Tomas

AU - Hansen, Anders J.

AU - Zhang, Guojie

AU - Bhak, Jong

AU - Yamaguchi, Nobuyuki

AU - Gilbert, M. Thomas P.

PY - 2020

Y1 - 2020

N2 - Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1–4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6–8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a7x nuclear genome and a38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11–14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.

AB - Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1–4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6–8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a7x nuclear genome and a38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11–14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.

U2 - 10.1016/j.cub.2020.09.051

DO - 10.1016/j.cub.2020.09.051

M3 - Journal article

C2 - 33065008

VL - 30

SP - 5018

EP - 5025

JO - Current Biology

JF - Current Biology

SN - 0960-9822

ER -

ID: 250920191