Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago

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Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago. / Rasmussen, Simon; Allentoft, Morten Erik; Nielsen, Kasper; Orlando, Ludovic Antoine Alexandre; Sikora, Martin; Sjögren, Karl-Göran; Pedersen, Anders Gorm; Schubert, Mikkel; Van Dam, Alex; Kapel, Christian Moliin Outzen; Nielsen, Henrik Bjørn; Brunak, Søren; Avetisyan, Pavel; Epimakhov, Andrey; Khalyapin, Mikhail Viktorovich; Gnuni, Artak; Kriiska, Aivar; Lasak, Irena; Metspalu, Mait; Moiseyev, Vyacheslav; Gromov, Andrei; Pokutta, Dalia; Saag, Lehti; Varul, Liivi; Yepiskoposyan, Levon; Sicheritz-Ponten, Thomas; Foley, Robert A; Lahr, Marta Mirazón; Nielsen, Rasmus; Kristiansen, Kristian; Willerslev, Eske.

In: Cell, Vol. 163, No. 3, 2015, p. 571-582.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Rasmussen, S, Allentoft, ME, Nielsen, K, Orlando, LAA, Sikora, M, Sjögren, K-G, Pedersen, AG, Schubert, M, Van Dam, A, Kapel, CMO, Nielsen, HB, Brunak, S, Avetisyan, P, Epimakhov, A, Khalyapin, MV, Gnuni, A, Kriiska, A, Lasak, I, Metspalu, M, Moiseyev, V, Gromov, A, Pokutta, D, Saag, L, Varul, L, Yepiskoposyan, L, Sicheritz-Ponten, T, Foley, RA, Lahr, MM, Nielsen, R, Kristiansen, K & Willerslev, E 2015, 'Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago', Cell, vol. 163, no. 3, pp. 571-582. https://doi.org/10.1016/j.cell.2015.10.009

APA

Rasmussen, S., Allentoft, M. E., Nielsen, K., Orlando, L. A. A., Sikora, M., Sjögren, K-G., ... Willerslev, E. (2015). Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago. Cell, 163(3), 571-582. https://doi.org/10.1016/j.cell.2015.10.009

Vancouver

Rasmussen S, Allentoft ME, Nielsen K, Orlando LAA, Sikora M, Sjögren K-G et al. Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago. Cell. 2015;163(3):571-582. https://doi.org/10.1016/j.cell.2015.10.009

Author

Rasmussen, Simon ; Allentoft, Morten Erik ; Nielsen, Kasper ; Orlando, Ludovic Antoine Alexandre ; Sikora, Martin ; Sjögren, Karl-Göran ; Pedersen, Anders Gorm ; Schubert, Mikkel ; Van Dam, Alex ; Kapel, Christian Moliin Outzen ; Nielsen, Henrik Bjørn ; Brunak, Søren ; Avetisyan, Pavel ; Epimakhov, Andrey ; Khalyapin, Mikhail Viktorovich ; Gnuni, Artak ; Kriiska, Aivar ; Lasak, Irena ; Metspalu, Mait ; Moiseyev, Vyacheslav ; Gromov, Andrei ; Pokutta, Dalia ; Saag, Lehti ; Varul, Liivi ; Yepiskoposyan, Levon ; Sicheritz-Ponten, Thomas ; Foley, Robert A ; Lahr, Marta Mirazón ; Nielsen, Rasmus ; Kristiansen, Kristian ; Willerslev, Eske. / Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago. In: Cell. 2015 ; Vol. 163, No. 3. pp. 571-582.

Bibtex

@article{d0db0bcabb2249c3ad165559ab73ea15,
title = "Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago",
abstract = "The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia pestis identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. By sequencing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis. We find the origins of the Yersinia pestis lineage to be at least two times older than previous estimates. We also identify a temporal sequence of genetic changes that lead to increased virulence and the emergence of the bubonic plague. Our results show that plague infection was endemic in the human populations of Eurasia at least 3,000 years before any historical recordings of pandemics.",
author = "Simon Rasmussen and Allentoft, {Morten Erik} and Kasper Nielsen and Orlando, {Ludovic Antoine Alexandre} and Martin Sikora and Karl-G{\"o}ran Sj{\"o}gren and Pedersen, {Anders Gorm} and Mikkel Schubert and {Van Dam}, Alex and Kapel, {Christian Moliin Outzen} and Nielsen, {Henrik Bj{\o}rn} and S{\o}ren Brunak and Pavel Avetisyan and Andrey Epimakhov and Khalyapin, {Mikhail Viktorovich} and Artak Gnuni and Aivar Kriiska and Irena Lasak and Mait Metspalu and Vyacheslav Moiseyev and Andrei Gromov and Dalia Pokutta and Lehti Saag and Liivi Varul and Levon Yepiskoposyan and Thomas Sicheritz-Ponten and Foley, {Robert A} and Lahr, {Marta Miraz{\'o}n} and Rasmus Nielsen and Kristian Kristiansen and Eske Willerslev",
note = "Copyright {\circledC} 2015 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2015",
doi = "10.1016/j.cell.2015.10.009",
language = "English",
volume = "163",
pages = "571--582",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago

AU - Rasmussen, Simon

AU - Allentoft, Morten Erik

AU - Nielsen, Kasper

AU - Orlando, Ludovic Antoine Alexandre

AU - Sikora, Martin

AU - Sjögren, Karl-Göran

AU - Pedersen, Anders Gorm

AU - Schubert, Mikkel

AU - Van Dam, Alex

AU - Kapel, Christian Moliin Outzen

AU - Nielsen, Henrik Bjørn

AU - Brunak, Søren

AU - Avetisyan, Pavel

AU - Epimakhov, Andrey

AU - Khalyapin, Mikhail Viktorovich

AU - Gnuni, Artak

AU - Kriiska, Aivar

AU - Lasak, Irena

AU - Metspalu, Mait

AU - Moiseyev, Vyacheslav

AU - Gromov, Andrei

AU - Pokutta, Dalia

AU - Saag, Lehti

AU - Varul, Liivi

AU - Yepiskoposyan, Levon

AU - Sicheritz-Ponten, Thomas

AU - Foley, Robert A

AU - Lahr, Marta Mirazón

AU - Nielsen, Rasmus

AU - Kristiansen, Kristian

AU - Willerslev, Eske

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2015

Y1 - 2015

N2 - The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia pestis identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. By sequencing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis. We find the origins of the Yersinia pestis lineage to be at least two times older than previous estimates. We also identify a temporal sequence of genetic changes that lead to increased virulence and the emergence of the bubonic plague. Our results show that plague infection was endemic in the human populations of Eurasia at least 3,000 years before any historical recordings of pandemics.

AB - The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia pestis identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. By sequencing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis. We find the origins of the Yersinia pestis lineage to be at least two times older than previous estimates. We also identify a temporal sequence of genetic changes that lead to increased virulence and the emergence of the bubonic plague. Our results show that plague infection was endemic in the human populations of Eurasia at least 3,000 years before any historical recordings of pandemics.

U2 - 10.1016/j.cell.2015.10.009

DO - 10.1016/j.cell.2015.10.009

M3 - Journal article

C2 - 26496604

VL - 163

SP - 571

EP - 582

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -

ID: 153427395