Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain
Research output: Contribution to journal › Journal article › Research › peer-review
Final published version, 288 KB, PDF document
Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral therapy. We have applied deep sequencing to characterize influenza intra-host variation in a transmission chain consisting of three cases due to oseltamivir-sensitive viruses, and one derived oseltamivir-resistant case.
|Number of pages||9|
|Publication status||Published - 2013|
Number of downloads are based on statistics from Google Scholar and www.ku.dk
No data available