Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain

Research output: Contribution to journalJournal articleResearchpeer-review


Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral therapy. We have applied deep sequencing to characterize influenza intra-host variation in a transmission chain consisting of three cases due to oseltamivir-sensitive viruses, and one derived oseltamivir-resistant case.
Original languageEnglish
Article number116
JournalVirology Journal
Number of pages9
Publication statusPublished - 2013

Number of downloads are based on statistics from Google Scholar and

No data available

ID: 46090172