Ancient and modern genomes unravel the evolutionary history of the rhinoceros family

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Ancient and modern genomes unravel the evolutionary history of the rhinoceros family. / Liu, Shanlin; Westbury, Michael V.; Dussex, Nicolas; Mitchell, Kieren J.; Sinding, Mikkel Holger S.; Heintzman, Peter D.; Duchêne, David A.; Kapp, Joshua D.; von Seth, Johanna; Heiniger, Holly; Sánchez-Barreiro, Fátima; Margaryan, Ashot; André-Olsen, Remi; De Cahsan, Binia; Meng, Guanliang; Yang, Chentao; Chen, Lei; van der Valk, Tom; Moodley, Yoshan; Rookmaaker, Kees; Bruford, Michael W.; Ryder, Oliver; Steiner, Cynthia; Sonsbeek, Linda G. R. Bruins-van; Vartanyan, Sergey; Guo, Chunxue; Cooper, Alan; Kosintsev, Pavel; Kirillova, Irina; Lister, Adrian M.; Marques-Bonet, Tomas; Gopalakrishnan, Shyam; Dunn, Robert R.; Lorenzen, Eline D.; Shapiro, Beth; Zhang, Guojie; Antoine, Pierre Olivier; Dalén, Love; Gilbert, M. Thomas P.

In: Cell, Vol. 184, No. 19, 2021, p. 4874-4885.e16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liu, S, Westbury, MV, Dussex, N, Mitchell, KJ, Sinding, MHS, Heintzman, PD, Duchêne, DA, Kapp, JD, von Seth, J, Heiniger, H, Sánchez-Barreiro, F, Margaryan, A, André-Olsen, R, De Cahsan, B, Meng, G, Yang, C, Chen, L, van der Valk, T, Moodley, Y, Rookmaaker, K, Bruford, MW, Ryder, O, Steiner, C, Sonsbeek, LGRB, Vartanyan, S, Guo, C, Cooper, A, Kosintsev, P, Kirillova, I, Lister, AM, Marques-Bonet, T, Gopalakrishnan, S, Dunn, RR, Lorenzen, ED, Shapiro, B, Zhang, G, Antoine, PO, Dalén, L & Gilbert, MTP 2021, 'Ancient and modern genomes unravel the evolutionary history of the rhinoceros family', Cell, vol. 184, no. 19, pp. 4874-4885.e16. https://doi.org/10.1016/j.cell.2021.07.032

APA

Liu, S., Westbury, M. V., Dussex, N., Mitchell, K. J., Sinding, M. H. S., Heintzman, P. D., Duchêne, D. A., Kapp, J. D., von Seth, J., Heiniger, H., Sánchez-Barreiro, F., Margaryan, A., André-Olsen, R., De Cahsan, B., Meng, G., Yang, C., Chen, L., van der Valk, T., Moodley, Y., ... Gilbert, M. T. P. (2021). Ancient and modern genomes unravel the evolutionary history of the rhinoceros family. Cell, 184(19), 4874-4885.e16. https://doi.org/10.1016/j.cell.2021.07.032

Vancouver

Liu S, Westbury MV, Dussex N, Mitchell KJ, Sinding MHS, Heintzman PD et al. Ancient and modern genomes unravel the evolutionary history of the rhinoceros family. Cell. 2021;184(19):4874-4885.e16. https://doi.org/10.1016/j.cell.2021.07.032

Author

Liu, Shanlin ; Westbury, Michael V. ; Dussex, Nicolas ; Mitchell, Kieren J. ; Sinding, Mikkel Holger S. ; Heintzman, Peter D. ; Duchêne, David A. ; Kapp, Joshua D. ; von Seth, Johanna ; Heiniger, Holly ; Sánchez-Barreiro, Fátima ; Margaryan, Ashot ; André-Olsen, Remi ; De Cahsan, Binia ; Meng, Guanliang ; Yang, Chentao ; Chen, Lei ; van der Valk, Tom ; Moodley, Yoshan ; Rookmaaker, Kees ; Bruford, Michael W. ; Ryder, Oliver ; Steiner, Cynthia ; Sonsbeek, Linda G. R. Bruins-van ; Vartanyan, Sergey ; Guo, Chunxue ; Cooper, Alan ; Kosintsev, Pavel ; Kirillova, Irina ; Lister, Adrian M. ; Marques-Bonet, Tomas ; Gopalakrishnan, Shyam ; Dunn, Robert R. ; Lorenzen, Eline D. ; Shapiro, Beth ; Zhang, Guojie ; Antoine, Pierre Olivier ; Dalén, Love ; Gilbert, M. Thomas P. / Ancient and modern genomes unravel the evolutionary history of the rhinoceros family. In: Cell. 2021 ; Vol. 184, No. 19. pp. 4874-4885.e16.

Bibtex

@article{f0add686d63b4386b4561c81a9e21f01,

title = "Ancient and modern genomes unravel the evolutionary history of the rhinoceros family",

abstract = "Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of their evolutionary history a challenge to biologists since Darwin. We sequenced genomes from five rhinoceros species (three extinct and two living), which we compared to existing data from the remaining three living species and a range of outgroups. We identify an early divergence between extant African and Eurasian lineages, resolving a key debate regarding the phylogeny of extant rhinoceroses. This early Miocene (∼16 million years ago [mya]) split post-dates the land bridge formation between the Afro-Arabian and Eurasian landmasses. Our analyses also show that while rhinoceros genomes in general exhibit low levels of genome-wide diversity, heterozygosity is lowest and inbreeding is highest in the modern species. These results suggest that while low genetic diversity is a long-term feature of the family, it has been particularly exacerbated recently, likely reflecting recent anthropogenic-driven population declines.",

keywords = "Rhinoceros, Perissodactyl, Conservation genomics, Phylogenomics, Genomic diversity",

author = "Shanlin Liu and Westbury, {Michael V.} and Nicolas Dussex and Mitchell, {Kieren J.} and Sinding, {Mikkel Holger S.} and Heintzman, {Peter D.} and Duch{\^e}ne, {David A.} and Kapp, {Joshua D.} and {von Seth}, Johanna and Holly Heiniger and F{\'a}tima S{\'a}nchez-Barreiro and Ashot Margaryan and Remi Andr{\'e}-Olsen and {De Cahsan}, Binia and Guanliang Meng and Chentao Yang and Lei Chen and {van der Valk}, Tom and Yoshan Moodley and Kees Rookmaaker and Bruford, {Michael W.} and Oliver Ryder and Cynthia Steiner and Sonsbeek, {Linda G. R. Bruins-van} and Sergey Vartanyan and Chunxue Guo and Alan Cooper and Pavel Kosintsev and Irina Kirillova and Lister, {Adrian M.} and Tomas Marques-Bonet and Shyam Gopalakrishnan and Dunn, {Robert R.} and Lorenzen, {Eline D.} and Beth Shapiro and Guojie Zhang and Antoine, {Pierre Olivier} and Love Dal{\'e}n and Gilbert, {M. Thomas P.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

doi = "10.1016/j.cell.2021.07.032",

language = "English",

volume = "184",

pages = "4874--4885.e16",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "19",

}

RIS

TY - JOUR

T1 - Ancient and modern genomes unravel the evolutionary history of the rhinoceros family

AU - Liu, Shanlin

AU - Westbury, Michael V.

AU - Dussex, Nicolas

AU - Mitchell, Kieren J.

AU - Sinding, Mikkel Holger S.

AU - Heintzman, Peter D.

AU - Duchêne, David A.

AU - Kapp, Joshua D.

AU - von Seth, Johanna

AU - Heiniger, Holly

AU - Sánchez-Barreiro, Fátima

AU - Margaryan, Ashot

AU - André-Olsen, Remi

AU - De Cahsan, Binia

AU - Meng, Guanliang

AU - Yang, Chentao

AU - Chen, Lei

AU - van der Valk, Tom

AU - Moodley, Yoshan

AU - Rookmaaker, Kees

AU - Bruford, Michael W.

AU - Ryder, Oliver

AU - Steiner, Cynthia

AU - Sonsbeek, Linda G. R. Bruins-van

AU - Vartanyan, Sergey

AU - Guo, Chunxue

AU - Cooper, Alan

AU - Kosintsev, Pavel

AU - Kirillova, Irina

AU - Lister, Adrian M.

AU - Marques-Bonet, Tomas

AU - Gopalakrishnan, Shyam

AU - Dunn, Robert R.

AU - Lorenzen, Eline D.

AU - Shapiro, Beth

AU - Zhang, Guojie

AU - Antoine, Pierre Olivier

AU - Dalén, Love

AU - Gilbert, M. Thomas P.

PY - 2021

Y1 - 2021

N2 - Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of their evolutionary history a challenge to biologists since Darwin. We sequenced genomes from five rhinoceros species (three extinct and two living), which we compared to existing data from the remaining three living species and a range of outgroups. We identify an early divergence between extant African and Eurasian lineages, resolving a key debate regarding the phylogeny of extant rhinoceroses. This early Miocene (∼16 million years ago [mya]) split post-dates the land bridge formation between the Afro-Arabian and Eurasian landmasses. Our analyses also show that while rhinoceros genomes in general exhibit low levels of genome-wide diversity, heterozygosity is lowest and inbreeding is highest in the modern species. These results suggest that while low genetic diversity is a long-term feature of the family, it has been particularly exacerbated recently, likely reflecting recent anthropogenic-driven population declines.

AB - Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of their evolutionary history a challenge to biologists since Darwin. We sequenced genomes from five rhinoceros species (three extinct and two living), which we compared to existing data from the remaining three living species and a range of outgroups. We identify an early divergence between extant African and Eurasian lineages, resolving a key debate regarding the phylogeny of extant rhinoceroses. This early Miocene (∼16 million years ago [mya]) split post-dates the land bridge formation between the Afro-Arabian and Eurasian landmasses. Our analyses also show that while rhinoceros genomes in general exhibit low levels of genome-wide diversity, heterozygosity is lowest and inbreeding is highest in the modern species. These results suggest that while low genetic diversity is a long-term feature of the family, it has been particularly exacerbated recently, likely reflecting recent anthropogenic-driven population declines.

KW - Rhinoceros, Perissodactyl, Conservation genomics, Phylogenomics, Genomic diversity

U2 - 10.1016/j.cell.2021.07.032

DO - 10.1016/j.cell.2021.07.032

M3 - Journal article

C2 - 34433011

AN - SCOPUS:85115014672

VL - 184

SP - 4874-4885.e16

JO - Cell

JF - Cell

SN - 0092-8674

IS - 19

ER -

ID: 281216987

Globe Institute