Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)

Research output: Contribution to journal › Journal article › Research › peer-review

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Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy). / Scorrano, Gabriele; Nielsen, Sofie Holtsmark; Vetro, Domenico Lo; Sawafuji, Rikai; Mackie, Meaghan; Margaryan, Ashot; Fotakis, Anna K.; Martínez-Labarga, Cristina; Fabbri, Pier Francesco; Allentoft, Morten E.; Carra, Marialetizia; Martini, Fabio; Rickards, Olga; Olsen, Jesper V.; Pedersen, Mikkel Winther; Cappellini, Enrico; Sikora, Martin.

In: Communications Biology, Vol. 5, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Scorrano, G, Nielsen, SH, Vetro, DL, Sawafuji, R, Mackie, M, Margaryan, A, Fotakis, AK, Martínez-Labarga, C, Fabbri, PF, Allentoft, ME, Carra, M, Martini, F, Rickards, O, Olsen, JV, Pedersen, MW, Cappellini, E & Sikora, M 2022, 'Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)', Communications Biology, vol. 5. https://doi.org/10.1038/s42003-022-04190-2

APA

Scorrano, G., Nielsen, S. H., Vetro, D. L., Sawafuji, R., Mackie, M., Margaryan, A., Fotakis, A. K., Martínez-Labarga, C., Fabbri, P. F., Allentoft, M. E., Carra, M., Martini, F., Rickards, O., Olsen, J. V., Pedersen, M. W., Cappellini, E., & Sikora, M. (2022). Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy). Communications Biology, 5. https://doi.org/10.1038/s42003-022-04190-2

Vancouver

Scorrano G, Nielsen SH, Vetro DL, Sawafuji R, Mackie M, Margaryan A et al. Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy). Communications Biology. 2022;5. https://doi.org/10.1038/s42003-022-04190-2

Author

Scorrano, Gabriele ; Nielsen, Sofie Holtsmark ; Vetro, Domenico Lo ; Sawafuji, Rikai ; Mackie, Meaghan ; Margaryan, Ashot ; Fotakis, Anna K. ; Martínez-Labarga, Cristina ; Fabbri, Pier Francesco ; Allentoft, Morten E. ; Carra, Marialetizia ; Martini, Fabio ; Rickards, Olga ; Olsen, Jesper V. ; Pedersen, Mikkel Winther ; Cappellini, Enrico ; Sikora, Martin. / Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy). In: Communications Biology. 2022 ; Vol. 5.

Bibtex

@article{41f1efa4f7d145c58efb5b7e4baa70e2,
title = "Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)",
abstract = "Recent improvements in the analysis of ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and genetic diversity of our species. Here we present a multi-omics study, integrating metagenomic and proteomic analyses of dental calculus, and human ancient DNA analysis of the petrous bones of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified Villabruna cluster. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analysis of dental calculus showed a diet rich in animal proteins which is also reflected on the oral microbiome composition. Our results demonstrate the power of this approach in the study of prehistoric humans and will enable future research to reach a more holistic understanding of the population dynamics and ecology.",
keywords = "genetics",
author = "Gabriele Scorrano and Nielsen, {Sofie Holtsmark} and Vetro, {Domenico Lo} and Rikai Sawafuji and Meaghan Mackie and Ashot Margaryan and Fotakis, {Anna K.} and Cristina Mart{\'i}nez-Labarga and Fabbri, {Pier Francesco} and Allentoft, {Morten E.} and Marialetizia Carra and Fabio Martini and Olga Rickards and Olsen, {Jesper V.} and Pedersen, {Mikkel Winther} and Enrico Cappellini and Martin Sikora",
year = "2022",
doi = "10.1038/s42003-022-04190-2",
language = "English",
volume = "5",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)

AU - Scorrano, Gabriele

AU - Nielsen, Sofie Holtsmark

AU - Vetro, Domenico Lo

AU - Sawafuji, Rikai

AU - Mackie, Meaghan

AU - Margaryan, Ashot

AU - Fotakis, Anna K.

AU - Martínez-Labarga, Cristina

AU - Fabbri, Pier Francesco

AU - Allentoft, Morten E.

AU - Carra, Marialetizia

AU - Martini, Fabio

AU - Rickards, Olga

AU - Olsen, Jesper V.

AU - Pedersen, Mikkel Winther

AU - Cappellini, Enrico

AU - Sikora, Martin

PY - 2022

Y1 - 2022

N2 - Recent improvements in the analysis of ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and genetic diversity of our species. Here we present a multi-omics study, integrating metagenomic and proteomic analyses of dental calculus, and human ancient DNA analysis of the petrous bones of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified Villabruna cluster. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analysis of dental calculus showed a diet rich in animal proteins which is also reflected on the oral microbiome composition. Our results demonstrate the power of this approach in the study of prehistoric humans and will enable future research to reach a more holistic understanding of the population dynamics and ecology.

AB - Recent improvements in the analysis of ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and genetic diversity of our species. Here we present a multi-omics study, integrating metagenomic and proteomic analyses of dental calculus, and human ancient DNA analysis of the petrous bones of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified Villabruna cluster. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analysis of dental calculus showed a diet rich in animal proteins which is also reflected on the oral microbiome composition. Our results demonstrate the power of this approach in the study of prehistoric humans and will enable future research to reach a more holistic understanding of the population dynamics and ecology.

KW - genetics

U2 - 10.1038/s42003-022-04190-2

DO - 10.1038/s42003-022-04190-2

M3 - Journal article

C2 - 36400919

VL - 5

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

ER -

ID: 327143251