Quantitative Human Paleogenetics: What can Ancient DNA Tell us About Complex Trait Evolution?
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Quantitative Human Paleogenetics : What can Ancient DNA Tell us About Complex Trait Evolution? / Irving-Pease, Evan K.; Muktupavela, Rasa; Dannemann, Michael; Racimo, Fernando.
In: Frontiers in Genetics, Vol. 12, 703541, 2021.Research output: Contribution to journal › Review › peer-review
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TY - JOUR
T1 - Quantitative Human Paleogenetics
T2 - What can Ancient DNA Tell us About Complex Trait Evolution?
AU - Irving-Pease, Evan K.
AU - Muktupavela, Rasa
AU - Dannemann, Michael
AU - Racimo, Fernando
N1 - Publisher Copyright: © Copyright © 2021 Irving-Pease, Muktupavela, Dannemann and Racimo.
PY - 2021
Y1 - 2021
N2 - Genetic association data from national biobanks and large-scale association studies have provided new prospects for understanding the genetic evolution of complex traits and diseases in humans. In turn, genomes from ancient human archaeological remains are now easier than ever to obtain, and provide a direct window into changes in frequencies of trait-associated alleles in the past. This has generated a new wave of studies aiming to analyse the genetic component of traits in historic and prehistoric times using ancient DNA, and to determine whether any such traits were subject to natural selection. In humans, however, issues about the portability and robustness of complex trait inference across different populations are particularly concerning when predictions are extended to individuals that died thousands of years ago, and for which little, if any, phenotypic validation is possible. In this review, we discuss the advantages of incorporating ancient genomes into studies of trait-associated variants, the need for models that can better accommodate ancient genomes into quantitative genetic frameworks, and the existing limits to inferences about complex trait evolution, particularly with respect to past populations.
AB - Genetic association data from national biobanks and large-scale association studies have provided new prospects for understanding the genetic evolution of complex traits and diseases in humans. In turn, genomes from ancient human archaeological remains are now easier than ever to obtain, and provide a direct window into changes in frequencies of trait-associated alleles in the past. This has generated a new wave of studies aiming to analyse the genetic component of traits in historic and prehistoric times using ancient DNA, and to determine whether any such traits were subject to natural selection. In humans, however, issues about the portability and robustness of complex trait inference across different populations are particularly concerning when predictions are extended to individuals that died thousands of years ago, and for which little, if any, phenotypic validation is possible. In this review, we discuss the advantages of incorporating ancient genomes into studies of trait-associated variants, the need for models that can better accommodate ancient genomes into quantitative genetic frameworks, and the existing limits to inferences about complex trait evolution, particularly with respect to past populations.
KW - aDNA
KW - complex traits
KW - GWAS
KW - paleogenetics
KW - polygenic adaptation
U2 - 10.3389/fgene.2021.703541
DO - 10.3389/fgene.2021.703541
M3 - Review
C2 - 34422004
AN - SCOPUS:85113185297
VL - 12
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
M1 - 703541
ER -
ID: 278281954