Unravelling animal–microbiota evolution on a chip

Research output: Contribution to journalReviewpeer-review

Whether and how microorganisms have shaped the evolution of their animal hosts is a major question in biology. Although many animal evolutionary processes appear to correlate with changes in their associated microbial communities, the mechanistic processes leading to these patterns and their causal relationships are still far from being resolved. Gut-on-a-chip models provide an innovative approach that expands beyond the potential of conventional microbiome profiling to study how different animals sense and react to microbes by comparing responses of animal intestinal tissue models to different microbial stimuli. This complementary knowledge can contribute to our understanding of how host genetic features facilitate or prevent different microbiomes from being assembled, and in doing so elucidate the role of host–microbiota interactions in animal evolution.

Original languageEnglish
JournalTrends in Microbiology
Number of pages8
Publication statusAccepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

    Research areas

  • gut-on-a-chip, host–microbiota interactions, in vitro models, MAMPs, PRRs

ID: 350910069