A strategic model of a host-microbe-microbe system reveals the importance of a joint host-microbe immune response to combat stress-induced gut dysbiosis
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A strategic model of a host-microbe-microbe system reveals the importance of a joint host-microbe immune response to combat stress-induced gut dysbiosis. / Scheuring, István; Rasmussen, Jacob A.; Bozzi, Davide; Limborg, Morten T.
In: Frontiers in Microbiology, Vol. 13, 912806, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A strategic model of a host-microbe-microbe system reveals the importance of a joint host-microbe immune response to combat stress-induced gut dysbiosis
AU - Scheuring, István
AU - Rasmussen, Jacob A.
AU - Bozzi, Davide
AU - Limborg, Morten T.
PY - 2022
Y1 - 2022
N2 - Microbiomes provide key ecological functions to their host; however, most host-associated microbiomes are too complicated to allow a model of essential host-microbe-microbe interactions. The intestinal microbiota of salmonids may offer a solution since few dominating species often characterize it. Healthy fish coexist with a mutualistic Mycoplasma sp. species, while stress allows the spread of pathogenic strains, such as Aliivibrio sp. Even after a skin infection, the Mycoplasma does not recover; Aliivibrio sp. often remains the dominant species, or Mycoplasma-Aliivibrio coexistence was occasionally observed. We devised a model involving interactions among the host immune system, Mycoplasma sp. plus a toxin-producing pathogen. Our model embraces a complete microbiota community and is in harmony with experimental results that host-Mycoplasma mutualism prevents the spread of pathogens. Contrary, stress suppresses the host immune system allowing dominance of pathogens, and Mycoplasma does not recover after stress disappears.
AB - Microbiomes provide key ecological functions to their host; however, most host-associated microbiomes are too complicated to allow a model of essential host-microbe-microbe interactions. The intestinal microbiota of salmonids may offer a solution since few dominating species often characterize it. Healthy fish coexist with a mutualistic Mycoplasma sp. species, while stress allows the spread of pathogenic strains, such as Aliivibrio sp. Even after a skin infection, the Mycoplasma does not recover; Aliivibrio sp. often remains the dominant species, or Mycoplasma-Aliivibrio coexistence was occasionally observed. We devised a model involving interactions among the host immune system, Mycoplasma sp. plus a toxin-producing pathogen. Our model embraces a complete microbiota community and is in harmony with experimental results that host-Mycoplasma mutualism prevents the spread of pathogens. Contrary, stress suppresses the host immune system allowing dominance of pathogens, and Mycoplasma does not recover after stress disappears.
KW - bistability
KW - mutualism
KW - stress
KW - pathogens
KW - salmonids
KW - microbiome
KW - Mycoplasma sp
KW - Aliivibrio sp
KW - SALMON SALMO-SALAR
KW - TROUT ONCORHYNCHUS-MYKISS
KW - ATLANTIC SALMON
KW - COMMUNITY
KW - EVOLUTION
KW - ANIMALS
KW - DISEASE
U2 - 10.3389/fmicb.2022.912806
DO - 10.3389/fmicb.2022.912806
M3 - Journal article
C2 - 35992720
VL - 13
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
SN - 1664-302X
M1 - 912806
ER -
ID: 318201411