Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis. / Olesen, Caroline M.; Clausen, Maja Lisa; Agner, Tove; Asplund, Maria; Rasmussen, Linett; Yüksel, Yasemine T.; Andersen, Paal S.; Litman, Thomas; Hansen, Anders J.; Barnes, Christopher J.

In: Acta Dermato-Venereologica, Vol. 102, adv00817, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olesen, CM, Clausen, ML, Agner, T, Asplund, M, Rasmussen, L, Yüksel, YT, Andersen, PS, Litman, T, Hansen, AJ & Barnes, CJ 2022, 'Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis', Acta Dermato-Venereologica, vol. 102, adv00817. https://doi.org/10.2340/actadv.v102.2275

APA

Olesen, C. M., Clausen, M. L., Agner, T., Asplund, M., Rasmussen, L., Yüksel, Y. T., Andersen, P. S., Litman, T., Hansen, A. J., & Barnes, C. J. (2022). Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis. Acta Dermato-Venereologica, 102, [adv00817]. https://doi.org/10.2340/actadv.v102.2275

Vancouver

Olesen CM, Clausen ML, Agner T, Asplund M, Rasmussen L, Yüksel YT et al. Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis. Acta Dermato-Venereologica. 2022;102. adv00817. https://doi.org/10.2340/actadv.v102.2275

Author

Olesen, Caroline M. ; Clausen, Maja Lisa ; Agner, Tove ; Asplund, Maria ; Rasmussen, Linett ; Yüksel, Yasemine T. ; Andersen, Paal S. ; Litman, Thomas ; Hansen, Anders J. ; Barnes, Christopher J. / Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis. In: Acta Dermato-Venereologica. 2022 ; Vol. 102.

Bibtex

@article{35fb64f013044490a45db59105dee305,
title = "Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis",
abstract = "The aim of this study was to investigate the early-life development of the skin microbiome in atopic derma-titis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and ec-zema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community struc-ture and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylo-cocci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic der-matitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.",
keywords = "atopic dermatitis, infant, skin microbiome",
author = "Olesen, {Caroline M.} and Clausen, {Maja Lisa} and Tove Agner and Maria Asplund and Linett Rasmussen and Y{\"u}ksel, {Yasemine T.} and Andersen, {Paal S.} and Thomas Litman and Hansen, {Anders J.} and Barnes, {Christopher J.}",
note = "Publisher Copyright: {\textcopyright} 2022, Medical Journals/Acta D-V. All rights reserved.",
year = "2022",
doi = "10.2340/actadv.v102.2275",
language = "English",
volume = "102",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",

}

RIS

TY - JOUR

T1 - Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis

AU - Olesen, Caroline M.

AU - Clausen, Maja Lisa

AU - Agner, Tove

AU - Asplund, Maria

AU - Rasmussen, Linett

AU - Yüksel, Yasemine T.

AU - Andersen, Paal S.

AU - Litman, Thomas

AU - Hansen, Anders J.

AU - Barnes, Christopher J.

N1 - Publisher Copyright: © 2022, Medical Journals/Acta D-V. All rights reserved.

PY - 2022

Y1 - 2022

N2 - The aim of this study was to investigate the early-life development of the skin microbiome in atopic derma-titis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and ec-zema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community struc-ture and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylo-cocci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic der-matitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.

AB - The aim of this study was to investigate the early-life development of the skin microbiome in atopic derma-titis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and ec-zema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community struc-ture and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylo-cocci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic der-matitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.

KW - atopic dermatitis

KW - infant

KW - skin microbiome

U2 - 10.2340/actadv.v102.2275

DO - 10.2340/actadv.v102.2275

M3 - Journal article

C2 - 35818733

AN - SCOPUS:85142377375

VL - 102

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

M1 - adv00817

ER -

ID: 327473453