Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Research output: Contribution to journal › Journal article › Research › peer-review

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Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. / Patrono, Livia V.; Vrancken, Bram; Budt, Matthias; Düx, Ariane; Lequime, Sebastian; Boral, Sengül; Gilbert, M. Thomas P.; Gogarten, Jan F.; Hoffmann, Luisa; Horst, David; Merkel, Kevin; Morens, David; Prepoint, Baptiste; Schlotterbeck, Jasmin; Schuenemann, Verena J.; Suchard, Marc A.; Taubenberger, Jeffery K.; Tenkhoff, Luisa; Urban, Christian; Widulin, Navena; Winter, Eduard; Worobey, Michael; Schnalke, Thomas; Wolff, Thorsten; Lemey, Philippe; Calvignac-Spencer, Sébastien.

In: Nature Communications, Vol. 13, 2314, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Patrono, LV, Vrancken, B, Budt, M, Düx, A, Lequime, S, Boral, S, Gilbert, MTP, Gogarten, JF, Hoffmann, L, Horst, D, Merkel, K, Morens, D, Prepoint, B, Schlotterbeck, J, Schuenemann, VJ, Suchard, MA, Taubenberger, JK, Tenkhoff, L, Urban, C, Widulin, N, Winter, E, Worobey, M, Schnalke, T, Wolff, T, Lemey, P & Calvignac-Spencer, S 2022, 'Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic', Nature Communications, vol. 13, 2314. https://doi.org/10.1038/s41467-022-29614-9

APA

Patrono, L. V., Vrancken, B., Budt, M., Düx, A., Lequime, S., Boral, S., Gilbert, M. T. P., Gogarten, J. F., Hoffmann, L., Horst, D., Merkel, K., Morens, D., Prepoint, B., Schlotterbeck, J., Schuenemann, V. J., Suchard, M. A., Taubenberger, J. K., Tenkhoff, L., Urban, C., ... Calvignac-Spencer, S. (2022). Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. Nature Communications, 13, [2314]. https://doi.org/10.1038/s41467-022-29614-9

Vancouver

Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S et al. Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. Nature Communications. 2022;13. 2314. https://doi.org/10.1038/s41467-022-29614-9

Author

Patrono, Livia V. ; Vrancken, Bram ; Budt, Matthias ; Düx, Ariane ; Lequime, Sebastian ; Boral, Sengül ; Gilbert, M. Thomas P. ; Gogarten, Jan F. ; Hoffmann, Luisa ; Horst, David ; Merkel, Kevin ; Morens, David ; Prepoint, Baptiste ; Schlotterbeck, Jasmin ; Schuenemann, Verena J. ; Suchard, Marc A. ; Taubenberger, Jeffery K. ; Tenkhoff, Luisa ; Urban, Christian ; Widulin, Navena ; Winter, Eduard ; Worobey, Michael ; Schnalke, Thomas ; Wolff, Thorsten ; Lemey, Philippe ; Calvignac-Spencer, Sébastien. / Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic. In: Nature Communications. 2022 ; Vol. 13.

Bibtex

@article{ff25ac6a60ed438db89512cf285213da,

title = "Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic",

abstract = "The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.",

author = "Patrono, {Livia V.} and Bram Vrancken and Matthias Budt and Ariane D{\"u}x and Sebastian Lequime and Seng{\"u}l Boral and Gilbert, {M. Thomas P.} and Gogarten, {Jan F.} and Luisa Hoffmann and David Horst and Kevin Merkel and David Morens and Baptiste Prepoint and Jasmin Schlotterbeck and Schuenemann, {Verena J.} and Suchard, {Marc A.} and Taubenberger, {Jeffery K.} and Luisa Tenkhoff and Christian Urban and Navena Widulin and Eduard Winter and Michael Worobey and Thomas Schnalke and Thorsten Wolff and Philippe Lemey and S{\'e}bastien Calvignac-Spencer",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "10.1038/s41467-022-29614-9",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

AU - Patrono, Livia V.

AU - Vrancken, Bram

AU - Budt, Matthias

AU - Düx, Ariane

AU - Lequime, Sebastian

AU - Boral, Sengül

AU - Gilbert, M. Thomas P.

AU - Gogarten, Jan F.

AU - Hoffmann, Luisa

AU - Horst, David

AU - Merkel, Kevin

AU - Morens, David

AU - Prepoint, Baptiste

AU - Schlotterbeck, Jasmin

AU - Schuenemann, Verena J.

AU - Suchard, Marc A.

AU - Taubenberger, Jeffery K.

AU - Tenkhoff, Luisa

AU - Urban, Christian

AU - Widulin, Navena

AU - Winter, Eduard

AU - Worobey, Michael

AU - Schnalke, Thomas

AU - Wolff, Thorsten

AU - Lemey, Philippe

AU - Calvignac-Spencer, Sébastien

PY - 2022

Y1 - 2022

N2 - The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

AB - The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events. Comparison of genomes before and during the pandemic peak shows variation at two sites in the nucleoprotein gene associated with resistance to host antiviral response, pointing at a possible adaptation of 1918 IAV to humans. Finally, local molecular clock modeling suggests a pure pandemic descent of seasonal H1N1 IAV as an alternative to the hypothesis of origination through an intrasubtype reassortment.

U2 - 10.1038/s41467-022-29614-9

DO - 10.1038/s41467-022-29614-9

M3 - Journal article

C2 - 35538057

AN - SCOPUS:85129776090

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2314

ER -

ID: 308860823

Globe Institute