Bone biodeterioration - The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community
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Bone biodeterioration - The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community. / Eriksen, Anne Marie Høier; Nielsen, Tue Kjærgaard; Matthiesen, Henning; Carøe, Christian; Hansen, Lars Hestbjerg; Gregory, David John; Turner-Walker, Gordon; Collins, Matthew James; Gilbert, Thomas M.P.
In: PLoS ONE, Vol. 15, No. 10 October, e0240512, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Bone biodeterioration - The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial community
AU - Eriksen, Anne Marie Høier
AU - Nielsen, Tue Kjærgaard
AU - Matthiesen, Henning
AU - Carøe, Christian
AU - Hansen, Lars Hestbjerg
AU - Gregory, David John
AU - Turner-Walker, Gordon
AU - Collins, Matthew James
AU - Gilbert, Thomas M.P.
PY - 2020
Y1 - 2020
N2 - Bacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity throughout the exposure period. We genetically profiled the bacterial community in an experimental series of pig bone fragments (femur and humeri) deposited at different well-defined environments in Denmark. The bacterial community in the bone fragments and surrounding depositional environment were studied over one year, and correlated with the bioerosion damage patterns observed microscopically in the bones. We observed that the bacterial communities within the bones were heavily influenced by the local microbial community, and that the general bone microbial diversity increases with time after exposure. We found the presence of several known collagenase producing bacterial groups, and also observed increases in the relative abundance of several of these in bones with tunneling. We anticipate that future analyses using shotgun metagenomics on this and similar datasets will be able to provide insights into mechanisms of microbiome driven bone degradation.
AB - Bacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity throughout the exposure period. We genetically profiled the bacterial community in an experimental series of pig bone fragments (femur and humeri) deposited at different well-defined environments in Denmark. The bacterial community in the bone fragments and surrounding depositional environment were studied over one year, and correlated with the bioerosion damage patterns observed microscopically in the bones. We observed that the bacterial communities within the bones were heavily influenced by the local microbial community, and that the general bone microbial diversity increases with time after exposure. We found the presence of several known collagenase producing bacterial groups, and also observed increases in the relative abundance of several of these in bones with tunneling. We anticipate that future analyses using shotgun metagenomics on this and similar datasets will be able to provide insights into mechanisms of microbiome driven bone degradation.
U2 - 10.1371/journal.pone.0240512
DO - 10.1371/journal.pone.0240512
M3 - Journal article
C2 - 33057402
AN - SCOPUS:85092771132
VL - 15
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 10 October
M1 - e0240512
ER -
ID: 252043638