Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. / Barrie, William; Yang, Yaoling; Irving-Pease, Evan K.; Attfield, Kathrine E.; Scorrano, Gabriele; Jensen, Lise Torp; Armen, Angelos P.; Dimopoulos, Evangelos Antonios; Stern, Aaron; Refoyo-Martinez, Alba; Pearson, Alice; Ramsøe, Abigail; Gaunitz, Charleen; Demeter, Fabrice; Jørkov, Marie Louise S.; Møller, Stig Bermann; Springborg, Bente; Klassen, Lutz; Hyldgård, Inger Marie; Wickmann, Niels; Vinner, Lasse; Korneliussen, Thorfinn Sand; Allentoft, Morten E.; Sikora, Martin; Kristiansen, Kristian; Rodriguez, Santiago; Nielsen, Rasmus; Iversen, Astrid K. N.; Lawson, Daniel J.; Fugger, Lars; Willerslev, Eske.

In: Nature, Vol. 625, No. 7994, 2024, p. 321-328.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Barrie, W, Yang, Y, Irving-Pease, EK, Attfield, KE, Scorrano, G, Jensen, LT, Armen, AP, Dimopoulos, EA, Stern, A, Refoyo-Martinez, A, Pearson, A, Ramsøe, A, Gaunitz, C, Demeter, F, Jørkov, MLS, Møller, SB, Springborg, B, Klassen, L, Hyldgård, IM, Wickmann, N, Vinner, L, Korneliussen, TS, Allentoft, ME, Sikora, M, Kristiansen, K, Rodriguez, S, Nielsen, R, Iversen, AKN, Lawson, DJ, Fugger, L & Willerslev, E 2024, 'Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations', Nature, vol. 625, no. 7994, pp. 321-328. https://doi.org/10.1038/s41586-023-06618-z

APA

Barrie, W., Yang, Y., Irving-Pease, E. K., Attfield, K. E., Scorrano, G., Jensen, L. T., Armen, A. P., Dimopoulos, E. A., Stern, A., Refoyo-Martinez, A., Pearson, A., Ramsøe, A., Gaunitz, C., Demeter, F., Jørkov, M. L. S., Møller, S. B., Springborg, B., Klassen, L., Hyldgård, I. M., ... Willerslev, E. (2024). Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. Nature, 625(7994), 321-328. https://doi.org/10.1038/s41586-023-06618-z

Vancouver

Barrie W, Yang Y, Irving-Pease EK, Attfield KE, Scorrano G, Jensen LT et al. Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. Nature. 2024;625(7994):321-328. https://doi.org/10.1038/s41586-023-06618-z

Author

Barrie, William ; Yang, Yaoling ; Irving-Pease, Evan K. ; Attfield, Kathrine E. ; Scorrano, Gabriele ; Jensen, Lise Torp ; Armen, Angelos P. ; Dimopoulos, Evangelos Antonios ; Stern, Aaron ; Refoyo-Martinez, Alba ; Pearson, Alice ; Ramsøe, Abigail ; Gaunitz, Charleen ; Demeter, Fabrice ; Jørkov, Marie Louise S. ; Møller, Stig Bermann ; Springborg, Bente ; Klassen, Lutz ; Hyldgård, Inger Marie ; Wickmann, Niels ; Vinner, Lasse ; Korneliussen, Thorfinn Sand ; Allentoft, Morten E. ; Sikora, Martin ; Kristiansen, Kristian ; Rodriguez, Santiago ; Nielsen, Rasmus ; Iversen, Astrid K. N. ; Lawson, Daniel J. ; Fugger, Lars ; Willerslev, Eske. / Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations. In: Nature. 2024 ; Vol. 625, No. 7994. pp. 321-328.

Bibtex

@article{26fc201abd7d4d5093d1b4316d7ac2ae,

title = "Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations",

abstract = "Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.",

author = "William Barrie and Yaoling Yang and Irving-Pease, {Evan K.} and Attfield, {Kathrine E.} and Gabriele Scorrano and Jensen, {Lise Torp} and Armen, {Angelos P.} and Dimopoulos, {Evangelos Antonios} and Aaron Stern and Alba Refoyo-Martinez and Alice Pearson and Abigail Rams{\o}e and Charleen Gaunitz and Fabrice Demeter and J{\o}rkov, {Marie Louise S.} and M{\o}ller, {Stig Bermann} and Bente Springborg and Lutz Klassen and Hyldg{\aa}rd, {Inger Marie} and Niels Wickmann and Lasse Vinner and Korneliussen, {Thorfinn Sand} and Allentoft, {Morten E.} and Martin Sikora and Kristian Kristiansen and Santiago Rodriguez and Rasmus Nielsen and Iversen, {Astrid K. N.} and Lawson, {Daniel J.} and Lars Fugger and Eske Willerslev",

note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",

year = "2024",

doi = "10.1038/s41586-023-06618-z",

language = "English",

volume = "625",

pages = "321--328",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "nature publishing group",

number = "7994",

}

RIS

TY - JOUR

T1 - Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

AU - Barrie, William

AU - Yang, Yaoling

AU - Irving-Pease, Evan K.

AU - Attfield, Kathrine E.

AU - Scorrano, Gabriele

AU - Jensen, Lise Torp

AU - Armen, Angelos P.

AU - Dimopoulos, Evangelos Antonios

AU - Stern, Aaron

AU - Refoyo-Martinez, Alba

AU - Pearson, Alice

AU - Ramsøe, Abigail

AU - Gaunitz, Charleen

AU - Demeter, Fabrice

AU - Jørkov, Marie Louise S.

AU - Møller, Stig Bermann

AU - Springborg, Bente

AU - Klassen, Lutz

AU - Hyldgård, Inger Marie

AU - Wickmann, Niels

AU - Vinner, Lasse

AU - Korneliussen, Thorfinn Sand

AU - Allentoft, Morten E.

AU - Sikora, Martin

AU - Kristiansen, Kristian

AU - Rodriguez, Santiago

AU - Nielsen, Rasmus

AU - Iversen, Astrid K. N.

AU - Lawson, Daniel J.

AU - Fugger, Lars

AU - Willerslev, Eske

PY - 2024

Y1 - 2024

N2 - Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.

AB - Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.

U2 - 10.1038/s41586-023-06618-z

DO - 10.1038/s41586-023-06618-z

M3 - Journal article

C2 - 38200296

AN - SCOPUS:85181501928

VL - 625

SP - 321

EP - 328

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 7994

ER -

ID: 380204730

Globe Institute