Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. / Rajagopal, Veera M.; Ganna, Andrea; Coleman, Jonathan R. I.; Allegrini, Andrea; Voloudakis, Georgios; Grove, Jakob; Als, Thomas D.; Horsdal, Henriette T.; Petersen, Liselotte; Appadurai, Vivek; Schork, Andrew; Buil, Alfonso; Bulik, Cynthia M.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Hougaard, David M.; Mors, Ole; Nordentoft, Merete; Werge, Thomas; Mortensen, Preben Bo; Breen, Gerome; Roussos, Panos; Plomin, Robert; Agerbo, Esben; Borglum, Anders D.; Demontis, Ditte; iPSYCH-Broad Consortium.

In: Scientific Reports, Vol. 13, 429, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rajagopal, VM, Ganna, A, Coleman, JRI, Allegrini, A, Voloudakis, G, Grove, J, Als, TD, Horsdal, HT, Petersen, L, Appadurai, V, Schork, A, Buil, A, Bulik, CM, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Hougaard, DM, Mors, O, Nordentoft, M, Werge, T, Mortensen, PB, Breen, G, Roussos, P, Plomin, R, Agerbo, E, Borglum, AD, Demontis, D & iPSYCH-Broad Consortium 2023, 'Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity', Scientific Reports, vol. 13, 429. https://doi.org/10.1038/s41598-022-26845-0

APA

Rajagopal, V. M., Ganna, A., Coleman, J. R. I., Allegrini, A., Voloudakis, G., Grove, J., Als, T. D., Horsdal, H. T., Petersen, L., Appadurai, V., Schork, A., Buil, A., Bulik, C. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, M., Werge, T., ... iPSYCH-Broad Consortium (2023). Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific Reports, 13, [429]. https://doi.org/10.1038/s41598-022-26845-0

Vancouver

Rajagopal VM, Ganna A, Coleman JRI, Allegrini A, Voloudakis G, Grove J et al. Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. Scientific Reports. 2023;13. 429. https://doi.org/10.1038/s41598-022-26845-0

Author

Rajagopal, Veera M. ; Ganna, Andrea ; Coleman, Jonathan R. I. ; Allegrini, Andrea ; Voloudakis, Georgios ; Grove, Jakob ; Als, Thomas D. ; Horsdal, Henriette T. ; Petersen, Liselotte ; Appadurai, Vivek ; Schork, Andrew ; Buil, Alfonso ; Bulik, Cynthia M. ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Marie ; Hougaard, David M. ; Mors, Ole ; Nordentoft, Merete ; Werge, Thomas ; Mortensen, Preben Bo ; Breen, Gerome ; Roussos, Panos ; Plomin, Robert ; Agerbo, Esben ; Borglum, Anders D. ; Demontis, Ditte ; iPSYCH-Broad Consortium. / Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity. In: Scientific Reports. 2023 ; Vol. 13.

Bibtex

@article{1962fd5bb13e463ab27726d169a822b1,
title = "Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity",
abstract = "Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.",
keywords = "BIPOLAR DISORDER, GENOTYPE IMPUTATION, WHOLE-GENOME, SCHIZOPHRENIA, RISK, ACHIEVEMENT, BIOBANK, PERFORMANCE, HAPLOTYPES, DEPRESSION",
author = "Rajagopal, {Veera M.} and Andrea Ganna and Coleman, {Jonathan R. I.} and Andrea Allegrini and Georgios Voloudakis and Jakob Grove and Als, {Thomas D.} and Horsdal, {Henriette T.} and Liselotte Petersen and Vivek Appadurai and Andrew Schork and Alfonso Buil and Bulik, {Cynthia M.} and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Hougaard, {David M.} and Ole Mors and Merete Nordentoft and Thomas Werge and Mortensen, {Preben Bo} and Gerome Breen and Panos Roussos and Robert Plomin and Esben Agerbo and Borglum, {Anders D.} and Ditte Demontis and {iPSYCH-Broad Consortium}",
year = "2023",
doi = "10.1038/s41598-022-26845-0",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

AU - Rajagopal, Veera M.

AU - Ganna, Andrea

AU - Coleman, Jonathan R. I.

AU - Allegrini, Andrea

AU - Voloudakis, Georgios

AU - Grove, Jakob

AU - Als, Thomas D.

AU - Horsdal, Henriette T.

AU - Petersen, Liselotte

AU - Appadurai, Vivek

AU - Schork, Andrew

AU - Buil, Alfonso

AU - Bulik, Cynthia M.

AU - Bybjerg-Grauholm, Jonas

AU - Bækvad-Hansen, Marie

AU - Hougaard, David M.

AU - Mors, Ole

AU - Nordentoft, Merete

AU - Werge, Thomas

AU - Mortensen, Preben Bo

AU - Breen, Gerome

AU - Roussos, Panos

AU - Plomin, Robert

AU - Agerbo, Esben

AU - Borglum, Anders D.

AU - Demontis, Ditte

AU - iPSYCH-Broad Consortium

PY - 2023

Y1 - 2023

N2 - Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.

AB - Cognitive functions of individuals with psychiatric disorders differ from that of the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured genetic predictors of school performance in 30,982 individuals in English, Danish and mathematics via a genome-wide association study (GWAS) and studied their relationship with risk for six major psychiatric disorders. When decomposing the school performance into math and language-specific performances, we observed phenotypically and genetically a strong negative correlation between math performance and risk for most psychiatric disorders. But language performance correlated positively with risk for certain disorders, especially schizophrenia, which we replicate in an independent sample (n = 4547). We also found that the genetic variants relating to increased risk for schizophrenia and better language performance are overrepresented in individuals involved in creative professions (n = 2953) compared to the general population (n = 164,622). The findings together suggest that language ability, creativity and psychopathology might stem from overlapping genetic roots.

KW - BIPOLAR DISORDER

KW - GENOTYPE IMPUTATION

KW - WHOLE-GENOME

KW - SCHIZOPHRENIA

KW - RISK

KW - ACHIEVEMENT

KW - BIOBANK

KW - PERFORMANCE

KW - HAPLOTYPES

KW - DEPRESSION

U2 - 10.1038/s41598-022-26845-0

DO - 10.1038/s41598-022-26845-0

M3 - Journal article

C2 - 36624241

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 429

ER -

ID: 339631389