Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)
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Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr). / Mochales-Riaño, Gabriel; Fontsere, Claudia; de Manuel, Marc; Talavera, Adrián; Burriel-Carranza, Bernat; Tejero-Cicuéndez, Héctor; AlGethami, Raed Hamoud M.; Shobrak, Mohammed; Marques-Bonet, Tomas; Carranza, Salvador.
In: iScience, Vol. 26, No. 9, 107481, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)
AU - Mochales-Riaño, Gabriel
AU - Fontsere, Claudia
AU - de Manuel, Marc
AU - Talavera, Adrián
AU - Burriel-Carranza, Bernat
AU - Tejero-Cicuéndez, Héctor
AU - AlGethami, Raed Hamoud M.
AU - Shobrak, Mohammed
AU - Marques-Bonet, Tomas
AU - Carranza, Salvador
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in endangered populations help to assess their vulnerability to extinction and to create informed management actions toward their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two Arabian leopards and assembled the most complete genomic dataset for leopards to date. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades: the African and the Asian. Conservation genomic analyses indicate a prolonged population decline, which has led to an increase in inbreeding and runs of homozygosity, with consequent purging of deleterious mutations in both Arabian individuals. Our study represents the first attempt to genetically inform captive breeding programmes for this Critically Endangered subspecies.
AB - In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in endangered populations help to assess their vulnerability to extinction and to create informed management actions toward their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two Arabian leopards and assembled the most complete genomic dataset for leopards to date. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades: the African and the Asian. Conservation genomic analyses indicate a prolonged population decline, which has led to an increase in inbreeding and runs of homozygosity, with consequent purging of deleterious mutations in both Arabian individuals. Our study represents the first attempt to genetically inform captive breeding programmes for this Critically Endangered subspecies.
KW - Genomics
KW - Zoology
U2 - 10.1016/j.isci.2023.107481
DO - 10.1016/j.isci.2023.107481
M3 - Journal article
C2 - 37601769
AN - SCOPUS:85167518115
VL - 26
JO - iScience
JF - iScience
SN - 2589-0042
IS - 9
M1 - 107481
ER -
ID: 362890467