Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations. / Vågene, Åshild J.; Honap, Tanvi P.; Harkins, Kelly M.; Rosenberg, Michael S.; Giffin, Karen; Cárdenas-Arroyo, Felipe; Leguizamón, Laura Paloma; Arnett, Judith; Buikstra, Jane E.; Herbig, Alexander; Krause, Johannes; Stone, Anne C.; Bos, Kirsten I.

In: Nature Communications, Vol. 13, 1195, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vågene, ÅJ, Honap, TP, Harkins, KM, Rosenberg, MS, Giffin, K, Cárdenas-Arroyo, F, Leguizamón, LP, Arnett, J, Buikstra, JE, Herbig, A, Krause, J, Stone, AC & Bos, KI 2022, 'Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations', Nature Communications, vol. 13, 1195. https://doi.org/10.1038/s41467-022-28562-8

APA

Vågene, Å. J., Honap, T. P., Harkins, K. M., Rosenberg, M. S., Giffin, K., Cárdenas-Arroyo, F., Leguizamón, L. P., Arnett, J., Buikstra, J. E., Herbig, A., Krause, J., Stone, A. C., & Bos, K. I. (2022). Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations. Nature Communications, 13, [1195]. https://doi.org/10.1038/s41467-022-28562-8

Vancouver

Vågene ÅJ, Honap TP, Harkins KM, Rosenberg MS, Giffin K, Cárdenas-Arroyo F et al. Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations. Nature Communications. 2022;13. 1195. https://doi.org/10.1038/s41467-022-28562-8

Author

Vågene, Åshild J. ; Honap, Tanvi P. ; Harkins, Kelly M. ; Rosenberg, Michael S. ; Giffin, Karen ; Cárdenas-Arroyo, Felipe ; Leguizamón, Laura Paloma ; Arnett, Judith ; Buikstra, Jane E. ; Herbig, Alexander ; Krause, Johannes ; Stone, Anne C. ; Bos, Kirsten I. / Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations. In: Nature Communications. 2022 ; Vol. 13.

Bibtex

@article{184b84f0330b440a956143a6b8cbf9f6,

title = "Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations",

abstract = "Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.",

author = "V{\aa}gene, {{\AA}shild J.} and Honap, {Tanvi P.} and Harkins, {Kelly M.} and Rosenberg, {Michael S.} and Karen Giffin and Felipe C{\'a}rdenas-Arroyo and Leguizam{\'o}n, {Laura Paloma} and Judith Arnett and Buikstra, {Jane E.} and Alexander Herbig and Johannes Krause and Stone, {Anne C.} and Bos, {Kirsten I.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "10.1038/s41467-022-28562-8",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations

AU - Vågene, Åshild J.

AU - Honap, Tanvi P.

AU - Harkins, Kelly M.

AU - Rosenberg, Michael S.

AU - Giffin, Karen

AU - Cárdenas-Arroyo, Felipe

AU - Leguizamón, Laura Paloma

AU - Arnett, Judith

AU - Buikstra, Jane E.

AU - Herbig, Alexander

AU - Krause, Johannes

AU - Stone, Anne C.

AU - Bos, Kirsten I.

PY - 2022

Y1 - 2022

N2 - Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.

AB - Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.

U2 - 10.1038/s41467-022-28562-8

DO - 10.1038/s41467-022-28562-8

M3 - Journal article

C2 - 35256608

AN - SCOPUS:85125973779

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1195

ER -

ID: 307227373

Globe Institute