Nano-Science Revelations in Bone Research

Research output: Contribution to journal › Review › Research › peer-review

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Nano-Science Revelations in Bone Research. / Hassenkam, Tue; Svensson, René Brüggebusch; Zalkovskij, Maksim.

In: Current Nanoscience, Vol. 3, No. 4, 2007, p. 345-351.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hassenkam, T, Svensson, RB & Zalkovskij, M 2007, 'Nano-Science Revelations in Bone Research', Current Nanoscience, vol. 3, no. 4, pp. 345-351. https://doi.org/10.2174/157341307782418621

APA

Hassenkam, T., Svensson, R. B., & Zalkovskij, M. (2007). Nano-Science Revelations in Bone Research. Current Nanoscience, 3(4), 345-351. https://doi.org/10.2174/157341307782418621

Vancouver

Hassenkam T, Svensson RB, Zalkovskij M. Nano-Science Revelations in Bone Research. Current Nanoscience. 2007;3(4):345-351. https://doi.org/10.2174/157341307782418621

Author

Hassenkam, Tue ; Svensson, René Brüggebusch ; Zalkovskij, Maksim. / Nano-Science Revelations in Bone Research. In: Current Nanoscience. 2007 ; Vol. 3, No. 4. pp. 345-351.

Bibtex

@article{a4c630ed936d4598a1f728eb46750bf6,
title = "Nano-Science Revelations in Bone Research",
abstract = "When diagnosing human bone as Osteoporotic, the quantity of bone, assessed by measurement of the bone mineral density (BMD), is often used in the estimate of fracture resistance. However, bone quantity is only one of the factors that determine the ability of bone to resist fracture. Bone quality describes the remaining characteristics and traits that determine the fracture resistance of bone. Bone is a composite material, consisting of minerals embedded in an organic matrix. The mechanical properties of a composite material are determined by the structural interactions of the individual constituents, which is different from the sum of mechanical properties of the individual constituents. The size of the building blocks of bone is in the nanometer range, the diameter of collagen is 100 nanometers and mineral plates range from the typical diameter of 10-20 nanometers to 200 nanometers. To understand the ability of bone to resist fracture, and its quality as a tissue, it is important to appreciate the intricate interplay between these building blocks. This review focuses on the parameters that contribute to bone quality, including recent evidence for the roles of factors such as collagen cross-linking, micro-cracking and bone remodeling.",
keywords = "AFM, Bone quality, Bone remodelling, Collagen cross-links, Micro-cracking, Nanostructure",
author = "Tue Hassenkam and Svensson, {Ren{\'e} Br{\"u}ggebusch} and Maksim Zalkovskij",
year = "2007",
doi = "10.2174/157341307782418621",
language = "English",
volume = "3",
pages = "345--351",
journal = "Current Nanoscience",
issn = "1573-4137",
publisher = "Bentham Science Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Nano-Science Revelations in Bone Research

AU - Hassenkam, Tue

AU - Svensson, René Brüggebusch

AU - Zalkovskij, Maksim

PY - 2007

Y1 - 2007

N2 - When diagnosing human bone as Osteoporotic, the quantity of bone, assessed by measurement of the bone mineral density (BMD), is often used in the estimate of fracture resistance. However, bone quantity is only one of the factors that determine the ability of bone to resist fracture. Bone quality describes the remaining characteristics and traits that determine the fracture resistance of bone. Bone is a composite material, consisting of minerals embedded in an organic matrix. The mechanical properties of a composite material are determined by the structural interactions of the individual constituents, which is different from the sum of mechanical properties of the individual constituents. The size of the building blocks of bone is in the nanometer range, the diameter of collagen is 100 nanometers and mineral plates range from the typical diameter of 10-20 nanometers to 200 nanometers. To understand the ability of bone to resist fracture, and its quality as a tissue, it is important to appreciate the intricate interplay between these building blocks. This review focuses on the parameters that contribute to bone quality, including recent evidence for the roles of factors such as collagen cross-linking, micro-cracking and bone remodeling.

AB - When diagnosing human bone as Osteoporotic, the quantity of bone, assessed by measurement of the bone mineral density (BMD), is often used in the estimate of fracture resistance. However, bone quantity is only one of the factors that determine the ability of bone to resist fracture. Bone quality describes the remaining characteristics and traits that determine the fracture resistance of bone. Bone is a composite material, consisting of minerals embedded in an organic matrix. The mechanical properties of a composite material are determined by the structural interactions of the individual constituents, which is different from the sum of mechanical properties of the individual constituents. The size of the building blocks of bone is in the nanometer range, the diameter of collagen is 100 nanometers and mineral plates range from the typical diameter of 10-20 nanometers to 200 nanometers. To understand the ability of bone to resist fracture, and its quality as a tissue, it is important to appreciate the intricate interplay between these building blocks. This review focuses on the parameters that contribute to bone quality, including recent evidence for the roles of factors such as collagen cross-linking, micro-cracking and bone remodeling.

KW - AFM

KW - Bone quality

KW - Bone remodelling

KW - Collagen cross-links

KW - Micro-cracking

KW - Nanostructure

U2 - 10.2174/157341307782418621

DO - 10.2174/157341307782418621

M3 - Review

AN - SCOPUS:36348931691

VL - 3

SP - 345

EP - 351

JO - Current Nanoscience

JF - Current Nanoscience

SN - 1573-4137

IS - 4

ER -

ID: 288849427