Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation. / Corbett-Detig, Russell B.; Russell, Shelbi L.; Nielsen, Rasmus; Losos, Jonathan.

In: MOLECULAR BIOLOGY AND EVOLUTION , Vol. 37, No. 6, 2020, p. 1604-1614.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Corbett-Detig, RB, Russell, SL, Nielsen, R & Losos, J 2020, 'Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation', MOLECULAR BIOLOGY AND EVOLUTION , vol. 37, no. 6, pp. 1604-1614. https://doi.org/10.1093/molbev/msaa028

APA

Corbett-Detig, R. B., Russell, S. L., Nielsen, R., & Losos, J. (2020). Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation. MOLECULAR BIOLOGY AND EVOLUTION , 37(6), 1604-1614. https://doi.org/10.1093/molbev/msaa028

Vancouver

Corbett-Detig RB, Russell SL, Nielsen R, Losos J. Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation. MOLECULAR BIOLOGY AND EVOLUTION . 2020;37(6):1604-1614. https://doi.org/10.1093/molbev/msaa028

Author

Corbett-Detig, Russell B. ; Russell, Shelbi L. ; Nielsen, Rasmus ; Losos, Jonathan. / Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation. In: MOLECULAR BIOLOGY AND EVOLUTION . 2020 ; Vol. 37, No. 6. pp. 1604-1614.

Bibtex

@article{1c2aa16fd0e147778f5e73d6d08d44ea,
title = "Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation",
abstract = "There are many compelling examples of molecular convergence at individual genes. However, the prevalence and the relative importance of adaptive genome-wide convergence remain largely unknown. Many recent works have reported striking examples of excess genome-wide convergence, but some of these studies have been called into question because of the use of inappropriate null models. Here, we sequenced and compared the genomes of 12 species of anole lizards that have independently converged on suites of adaptive behavioral and morphological traits. Despite extensive searches for a genome-wide signature of molecular convergence, we found no evidence supporting molecular convergence at specific amino acids either at individual genes or at genome-wide comparisons; we also uncovered no evidence supporting an excess of adaptive convergence in the rates of amino acid substitutions within genes. Our findings indicate that comprehensive phenotypic convergence is not mirrored at genome-wide protein-coding levels in anoles, and therefore, that adaptive phenotypic convergence is likely not constrained by the evolution of many specific protein sequences or structures.",
keywords = "molecular evolution, convergence, Anolis, MOLECULAR CONVERGENCE, PHYLOGENETIC ANALYSIS, EVOLUTION, GENOME, CONCORDANCE, HOMOPLASY, MAFFT, TOOL",
author = "Corbett-Detig, {Russell B.} and Russell, {Shelbi L.} and Rasmus Nielsen and Jonathan Losos",
year = "2020",
doi = "10.1093/molbev/msaa028",
language = "English",
volume = "37",
pages = "1604--1614",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Phenotypic Convergence Is Not Mirrored at the Protein Level in a Lizard Adaptive Radiation

AU - Corbett-Detig, Russell B.

AU - Russell, Shelbi L.

AU - Nielsen, Rasmus

AU - Losos, Jonathan

PY - 2020

Y1 - 2020

N2 - There are many compelling examples of molecular convergence at individual genes. However, the prevalence and the relative importance of adaptive genome-wide convergence remain largely unknown. Many recent works have reported striking examples of excess genome-wide convergence, but some of these studies have been called into question because of the use of inappropriate null models. Here, we sequenced and compared the genomes of 12 species of anole lizards that have independently converged on suites of adaptive behavioral and morphological traits. Despite extensive searches for a genome-wide signature of molecular convergence, we found no evidence supporting molecular convergence at specific amino acids either at individual genes or at genome-wide comparisons; we also uncovered no evidence supporting an excess of adaptive convergence in the rates of amino acid substitutions within genes. Our findings indicate that comprehensive phenotypic convergence is not mirrored at genome-wide protein-coding levels in anoles, and therefore, that adaptive phenotypic convergence is likely not constrained by the evolution of many specific protein sequences or structures.

AB - There are many compelling examples of molecular convergence at individual genes. However, the prevalence and the relative importance of adaptive genome-wide convergence remain largely unknown. Many recent works have reported striking examples of excess genome-wide convergence, but some of these studies have been called into question because of the use of inappropriate null models. Here, we sequenced and compared the genomes of 12 species of anole lizards that have independently converged on suites of adaptive behavioral and morphological traits. Despite extensive searches for a genome-wide signature of molecular convergence, we found no evidence supporting molecular convergence at specific amino acids either at individual genes or at genome-wide comparisons; we also uncovered no evidence supporting an excess of adaptive convergence in the rates of amino acid substitutions within genes. Our findings indicate that comprehensive phenotypic convergence is not mirrored at genome-wide protein-coding levels in anoles, and therefore, that adaptive phenotypic convergence is likely not constrained by the evolution of many specific protein sequences or structures.

KW - molecular evolution

KW - convergence

KW - Anolis

KW - MOLECULAR CONVERGENCE

KW - PHYLOGENETIC ANALYSIS

KW - EVOLUTION

KW - GENOME

KW - CONCORDANCE

KW - HOMOPLASY

KW - MAFFT

KW - TOOL

U2 - 10.1093/molbev/msaa028

DO - 10.1093/molbev/msaa028

M3 - Journal article

C2 - 32027369

VL - 37

SP - 1604

EP - 1614

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 6

ER -

ID: 250549758