Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain

Research output: Contribution to journal › Journal article › Research › peer-review

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Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain. / van Dorp, Lucy; Gelabert, Pere; Rieux, Adrien; de Manuel, Marc; de-Dios, Toni; Gopalakrishnan, Shyam; Caroe, Christian; Sandoval-Velasco, Marcela; Fregel, Rosa; Olalde, Inigo; Escosa, Raul; Aranda, Carles; Huijben, Silvie; Mueller, Ivo; Marques-Bonet, Tomas; Balloux, Francois; Gilbert, M. Thomas P.; Lalueza-Fox, Carles.

In: MOLECULAR BIOLOGY AND EVOLUTION , Vol. 37, No. 3, 2020, p. 773-785.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

van Dorp, L, Gelabert, P, Rieux, A, de Manuel, M, de-Dios, T, Gopalakrishnan, S, Caroe, C, Sandoval-Velasco, M, Fregel, R, Olalde, I, Escosa, R, Aranda, C, Huijben, S, Mueller, I, Marques-Bonet, T, Balloux, F, Gilbert, MTP & Lalueza-Fox, C 2020, 'Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain', MOLECULAR BIOLOGY AND EVOLUTION , vol. 37, no. 3, pp. 773-785. https://doi.org/10.1093/molbev/msz264

APA

van Dorp, L., Gelabert, P., Rieux, A., de Manuel, M., de-Dios, T., Gopalakrishnan, S., Caroe, C., Sandoval-Velasco, M., Fregel, R., Olalde, I., Escosa, R., Aranda, C., Huijben, S., Mueller, I., Marques-Bonet, T., Balloux, F., Gilbert, M. T. P., & Lalueza-Fox, C. (2020). Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain. MOLECULAR BIOLOGY AND EVOLUTION , 37(3), 773-785. https://doi.org/10.1093/molbev/msz264

Vancouver

van Dorp L, Gelabert P, Rieux A, de Manuel M, de-Dios T, Gopalakrishnan S et al. Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain. MOLECULAR BIOLOGY AND EVOLUTION . 2020;37(3):773-785. https://doi.org/10.1093/molbev/msz264

Author

van Dorp, Lucy ; Gelabert, Pere ; Rieux, Adrien ; de Manuel, Marc ; de-Dios, Toni ; Gopalakrishnan, Shyam ; Caroe, Christian ; Sandoval-Velasco, Marcela ; Fregel, Rosa ; Olalde, Inigo ; Escosa, Raul ; Aranda, Carles ; Huijben, Silvie ; Mueller, Ivo ; Marques-Bonet, Tomas ; Balloux, Francois ; Gilbert, M. Thomas P. ; Lalueza-Fox, Carles. / Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain. In: MOLECULAR BIOLOGY AND EVOLUTION . 2020 ; Vol. 37, No. 3. pp. 773-785.

Bibtex

@article{715f9410d509486eb416667b4e718247,
title = "Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain",
abstract = "The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonization of the Americas. In addition, we found that some known variants for resistance to antimalarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.",
keywords = "malaria, Plasmodium vivax, phylogenetics, ancient DNA, population genetics, SINGLE-NUCLEOTIDE POLYMORPHISMS, DRUG-RESISTANCE, DIHYDROFOLATE-REDUCTASE, LINKAGE DISEQUILIBRIUM, DIHYDROPTEROATE SYNTHASE, CHLOROQUINE RESISTANCE, POPULATION GENOMICS, FALCIPARUM, GENE, DIVERSITY",
author = "{van Dorp}, Lucy and Pere Gelabert and Adrien Rieux and {de Manuel}, Marc and Toni de-Dios and Shyam Gopalakrishnan and Christian Caroe and Marcela Sandoval-Velasco and Rosa Fregel and Inigo Olalde and Raul Escosa and Carles Aranda and Silvie Huijben and Ivo Mueller and Tomas Marques-Bonet and Francois Balloux and Gilbert, {M. Thomas P.} and Carles Lalueza-Fox",
year = "2020",
doi = "10.1093/molbev/msz264",
language = "English",
volume = "37",
pages = "773--785",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain

AU - van Dorp, Lucy

AU - Gelabert, Pere

AU - Rieux, Adrien

AU - de Manuel, Marc

AU - de-Dios, Toni

AU - Gopalakrishnan, Shyam

AU - Caroe, Christian

AU - Sandoval-Velasco, Marcela

AU - Fregel, Rosa

AU - Olalde, Inigo

AU - Escosa, Raul

AU - Aranda, Carles

AU - Huijben, Silvie

AU - Mueller, Ivo

AU - Marques-Bonet, Tomas

AU - Balloux, Francois

AU - Gilbert, M. Thomas P.

AU - Lalueza-Fox, Carles

PY - 2020

Y1 - 2020

N2 - The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonization of the Americas. In addition, we found that some known variants for resistance to antimalarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.

AB - The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonization of the Americas. In addition, we found that some known variants for resistance to antimalarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.

KW - malaria

KW - Plasmodium vivax

KW - phylogenetics

KW - ancient DNA

KW - population genetics

KW - SINGLE-NUCLEOTIDE POLYMORPHISMS

KW - DRUG-RESISTANCE

KW - DIHYDROFOLATE-REDUCTASE

KW - LINKAGE DISEQUILIBRIUM

KW - DIHYDROPTEROATE SYNTHASE

KW - CHLOROQUINE RESISTANCE

KW - POPULATION GENOMICS

KW - FALCIPARUM

KW - GENE

KW - DIVERSITY

U2 - 10.1093/molbev/msz264

DO - 10.1093/molbev/msz264

M3 - Journal article

C2 - 31697387

VL - 37

SP - 773

EP - 785

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 3

ER -

ID: 245368573