Purging and accumulation of genetic load in conservation

Research output: Contribution to journal › Journal article › Research › peer-review

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Purging and accumulation of genetic load in conservation. / Dussex, Nicolas; Morales, Hernán E.; Grossen, Christine; Dalén, Love; van Oosterhout, Cock.

In: Trends in Ecology and Evolution, Vol. 38, No. 10, 2023, p. 961-969.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dussex, N, Morales, HE, Grossen, C, Dalén, L & van Oosterhout, C 2023, 'Purging and accumulation of genetic load in conservation', Trends in Ecology and Evolution, vol. 38, no. 10, pp. 961-969. https://doi.org/10.1016/j.tree.2023.05.008

APA

Dussex, N., Morales, H. E., Grossen, C., Dalén, L., & van Oosterhout, C. (2023). Purging and accumulation of genetic load in conservation. Trends in Ecology and Evolution, 38(10), 961-969. https://doi.org/10.1016/j.tree.2023.05.008

Vancouver

Dussex N, Morales HE, Grossen C, Dalén L, van Oosterhout C. Purging and accumulation of genetic load in conservation. Trends in Ecology and Evolution. 2023;38(10):961-969. https://doi.org/10.1016/j.tree.2023.05.008

Author

Dussex, Nicolas ; Morales, Hernán E. ; Grossen, Christine ; Dalén, Love ; van Oosterhout, Cock. / Purging and accumulation of genetic load in conservation. In: Trends in Ecology and Evolution. 2023 ; Vol. 38, No. 10. pp. 961-969.

Bibtex

@article{02ba1ef90d554da8b80fa8294aa72e72,

title = "Purging and accumulation of genetic load in conservation",

abstract = "Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.",

keywords = "bottleneck, conservation, genetic load, genomic erosion, purging",

author = "Nicolas Dussex and Morales, {Hern{\'a}n E.} and Christine Grossen and Love Dal{\'e}n and {van Oosterhout}, Cock",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

doi = "10.1016/j.tree.2023.05.008",

language = "English",

volume = "38",

pages = "961--969",

journal = "Trends in Ecology & Evolution",

issn = "0169-5347",

publisher = "Elsevier Ltd. * Trends Journals",

number = "10",

}

RIS

TY - JOUR

T1 - Purging and accumulation of genetic load in conservation

AU - Dussex, Nicolas

AU - Morales, Hernán E.

AU - Grossen, Christine

AU - Dalén, Love

AU - van Oosterhout, Cock

PY - 2023

Y1 - 2023

N2 - Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.

AB - Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the genetic load and its dynamics, and how they impact individual fitness and population viability. We illustrate how both selective purging and drift affect the distribution of deleterious mutations during population size decline and recovery. We show how this impacts the composition of the genetic load, and how this affects the extinction risk and recovery potential of populations. We propose a framework to examine load dynamics and advocate for the introduction of load estimates in the management of endangered populations.

KW - bottleneck

KW - conservation

KW - genetic load

KW - genomic erosion

KW - purging

U2 - 10.1016/j.tree.2023.05.008

DO - 10.1016/j.tree.2023.05.008

M3 - Journal article

C2 - 37344276

AN - SCOPUS:85162202090

VL - 38

SP - 961

EP - 969

JO - Trends in Ecology & Evolution

JF - Trends in Ecology & Evolution

SN - 0169-5347

IS - 10

ER -

ID: 358089732

Globe Institute