Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. / Fantner, Georg E.; Hassenkam, Tue; Kindt, Johannes H.; Weaver, James C.; Birkedal, Henrik; Pechenik, Leonid; Cutroni, Jacqueline A.; Cidade, Geraldo A. G.; Stucky, Galen D.; Morse, Daniel E.; Hansma, Paul K.

In: Nature Materials, Vol. 4, No. 8, 2005, p. 612-616.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Fantner, GE, Hassenkam, T, Kindt, JH, Weaver, JC, Birkedal, H, Pechenik, L, Cutroni, JA, Cidade, GAG, Stucky, GD, Morse, DE & Hansma, PK 2005, 'Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture', Nature Materials, vol. 4, no. 8, pp. 612-616. https://doi.org/10.1038/nmat1428

APA

Fantner, G. E., Hassenkam, T., Kindt, J. H., Weaver, J. C., Birkedal, H., Pechenik, L., Cutroni, J. A., Cidade, G. A. G., Stucky, G. D., Morse, D. E., & Hansma, P. K. (2005). Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nature Materials, 4(8), 612-616. https://doi.org/10.1038/nmat1428

Vancouver

Fantner GE, Hassenkam T, Kindt JH, Weaver JC, Birkedal H, Pechenik L et al. Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nature Materials. 2005;4(8):612-616. https://doi.org/10.1038/nmat1428

Author

Fantner, Georg E. ; Hassenkam, Tue ; Kindt, Johannes H. ; Weaver, James C. ; Birkedal, Henrik ; Pechenik, Leonid ; Cutroni, Jacqueline A. ; Cidade, Geraldo A. G. ; Stucky, Galen D. ; Morse, Daniel E. ; Hansma, Paul K. / Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. In: Nature Materials. 2005 ; Vol. 4, No. 8. pp. 612-616.

Bibtex

@article{c0cef8d4ea154964aa11d62fbf552557,
title = "Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture",
abstract = "Properties of the organic matrix of bone1 as well as its function in the microstructure2 could be the key to the remarkable mechanical properties of bone3. Previously, it was found that on the molecular level, calcium-mediated sacrificial bonds increased stiffness and enhanced energy dissipation in bone constituent molecules4,5. Here we present evidence for how this sacrificial bond and hidden length mechanism contributes to the mechanical properties of the bone composite, by investigating the nanoscale arrangement of the bone constituents6-8 and their interactions. We find evidence that bone consists of mineralized collagen fibrils and a non-fibrillar organic matrix2, which acts as a 'glue' that holds the mineralized fibrils together. We believe that this glue may resist the separation of mineralized collagen fibrils. As in the case of the sacrificial bonds in single molecules5, the effectiveness of this mechanism increases with the presence of Ca2+ ions.",
author = "Fantner, {Georg E.} and Tue Hassenkam and Kindt, {Johannes H.} and Weaver, {James C.} and Henrik Birkedal and Leonid Pechenik and Cutroni, {Jacqueline A.} and Cidade, {Geraldo A. G.} and Stucky, {Galen D.} and Morse, {Daniel E.} and Hansma, {Paul K.}",
note = "Funding Information: TheauthorswouldliketothankA.Diez-Perez,H. Waite,K.Fields,S. Weiner, M.Rief, W. Landis, P. Fratzl and S. Masahiko for their suggestions and discussion. We also thank Gelson{\textquoteright}s Markets, Santa Barbara, especially Phil Vega, for supplying fresh bovine vertebrae. This research was supported by: NASA University Research, Engineering and Technology Institute on Bio Inspired Materials, NIH, NSF, the Institute for Collaborative Biotechnologies from the US Army Research Office, VeecoInstruments, theUCSBMaterials Research Laboratory, the NOAA National SeaGrant CollegeProgram,USDeptof Commerce through the California Sea Grant College System and a CNPq Fellowship, Brazil. T.H. and H.B. thank the Danish research council for additional support. G.F. thanks the Austrian Academy of Science for a DOC scholarship. CorrespondenceandrequestsformaterialsshouldbeaddressedtoG.E.F.",
year = "2005",
doi = "10.1038/nmat1428",
language = "English",
volume = "4",
pages = "612--616",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "nature publishing group",
number = "8",

}

RIS

TY - JOUR

T1 - Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture

AU - Fantner, Georg E.

AU - Hassenkam, Tue

AU - Kindt, Johannes H.

AU - Weaver, James C.

AU - Birkedal, Henrik

AU - Pechenik, Leonid

AU - Cutroni, Jacqueline A.

AU - Cidade, Geraldo A. G.

AU - Stucky, Galen D.

AU - Morse, Daniel E.

AU - Hansma, Paul K.

N1 - Funding Information: TheauthorswouldliketothankA.Diez-Perez,H. Waite,K.Fields,S. Weiner, M.Rief, W. Landis, P. Fratzl and S. Masahiko for their suggestions and discussion. We also thank Gelson’s Markets, Santa Barbara, especially Phil Vega, for supplying fresh bovine vertebrae. This research was supported by: NASA University Research, Engineering and Technology Institute on Bio Inspired Materials, NIH, NSF, the Institute for Collaborative Biotechnologies from the US Army Research Office, VeecoInstruments, theUCSBMaterials Research Laboratory, the NOAA National SeaGrant CollegeProgram,USDeptof Commerce through the California Sea Grant College System and a CNPq Fellowship, Brazil. T.H. and H.B. thank the Danish research council for additional support. G.F. thanks the Austrian Academy of Science for a DOC scholarship. CorrespondenceandrequestsformaterialsshouldbeaddressedtoG.E.F.

PY - 2005

Y1 - 2005

N2 - Properties of the organic matrix of bone1 as well as its function in the microstructure2 could be the key to the remarkable mechanical properties of bone3. Previously, it was found that on the molecular level, calcium-mediated sacrificial bonds increased stiffness and enhanced energy dissipation in bone constituent molecules4,5. Here we present evidence for how this sacrificial bond and hidden length mechanism contributes to the mechanical properties of the bone composite, by investigating the nanoscale arrangement of the bone constituents6-8 and their interactions. We find evidence that bone consists of mineralized collagen fibrils and a non-fibrillar organic matrix2, which acts as a 'glue' that holds the mineralized fibrils together. We believe that this glue may resist the separation of mineralized collagen fibrils. As in the case of the sacrificial bonds in single molecules5, the effectiveness of this mechanism increases with the presence of Ca2+ ions.

AB - Properties of the organic matrix of bone1 as well as its function in the microstructure2 could be the key to the remarkable mechanical properties of bone3. Previously, it was found that on the molecular level, calcium-mediated sacrificial bonds increased stiffness and enhanced energy dissipation in bone constituent molecules4,5. Here we present evidence for how this sacrificial bond and hidden length mechanism contributes to the mechanical properties of the bone composite, by investigating the nanoscale arrangement of the bone constituents6-8 and their interactions. We find evidence that bone consists of mineralized collagen fibrils and a non-fibrillar organic matrix2, which acts as a 'glue' that holds the mineralized fibrils together. We believe that this glue may resist the separation of mineralized collagen fibrils. As in the case of the sacrificial bonds in single molecules5, the effectiveness of this mechanism increases with the presence of Ca2+ ions.

U2 - 10.1038/nmat1428

DO - 10.1038/nmat1428

M3 - Letter

C2 - 16025123

AN - SCOPUS:23244461731

VL - 4

SP - 612

EP - 616

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 8

ER -

ID: 288849731