The Australian dingo is an early offshoot of modern breed dogs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The Australian dingo is an early offshoot of modern breed dogs. / Field, Matt A.; Yadav, Sonu; Dudchenko, Olga; Esvaran, Meera; Rosen, Benjamin D.; Skvortsova, Ksenia; Edwards, Richard J.; Keilwagen, Jens; Cochran, Blake J.; Manandhar, Bikash; Bustamante, Sonia; Rasmussen, Jacob Agerbo; Melvin, Richard G.; Chernoff, Barry; Omer, Arina; Colaric, Zane; Chan, Eva K. F.; Minoche, Andre E.; Smith, Timothy P. L.; Gilbert, M. Thomas P.; Bogdanovic, Ozren; Zammit, Robert A.; Thomas, Torsten; Aiden, Erez L.; Ballard, J. William O.

In: Science Advances, Vol. 8, No. 16, eabm5944, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Field, MA, Yadav, S, Dudchenko, O, Esvaran, M, Rosen, BD, Skvortsova, K, Edwards, RJ, Keilwagen, J, Cochran, BJ, Manandhar, B, Bustamante, S, Rasmussen, JA, Melvin, RG, Chernoff, B, Omer, A, Colaric, Z, Chan, EKF, Minoche, AE, Smith, TPL, Gilbert, MTP, Bogdanovic, O, Zammit, RA, Thomas, T, Aiden, EL & Ballard, JWO 2022, 'The Australian dingo is an early offshoot of modern breed dogs', Science Advances, vol. 8, no. 16, eabm5944. https://doi.org/10.1126/sciadv.abm5944

APA

Field, M. A., Yadav, S., Dudchenko, O., Esvaran, M., Rosen, B. D., Skvortsova, K., Edwards, R. J., Keilwagen, J., Cochran, B. J., Manandhar, B., Bustamante, S., Rasmussen, J. A., Melvin, R. G., Chernoff, B., Omer, A., Colaric, Z., Chan, E. K. F., Minoche, A. E., Smith, T. P. L., ... Ballard, J. W. O. (2022). The Australian dingo is an early offshoot of modern breed dogs. Science Advances, 8(16), [eabm5944]. https://doi.org/10.1126/sciadv.abm5944

Vancouver

Field MA, Yadav S, Dudchenko O, Esvaran M, Rosen BD, Skvortsova K et al. The Australian dingo is an early offshoot of modern breed dogs. Science Advances. 2022;8(16). eabm5944. https://doi.org/10.1126/sciadv.abm5944

Author

Field, Matt A. ; Yadav, Sonu ; Dudchenko, Olga ; Esvaran, Meera ; Rosen, Benjamin D. ; Skvortsova, Ksenia ; Edwards, Richard J. ; Keilwagen, Jens ; Cochran, Blake J. ; Manandhar, Bikash ; Bustamante, Sonia ; Rasmussen, Jacob Agerbo ; Melvin, Richard G. ; Chernoff, Barry ; Omer, Arina ; Colaric, Zane ; Chan, Eva K. F. ; Minoche, Andre E. ; Smith, Timothy P. L. ; Gilbert, M. Thomas P. ; Bogdanovic, Ozren ; Zammit, Robert A. ; Thomas, Torsten ; Aiden, Erez L. ; Ballard, J. William O. / The Australian dingo is an early offshoot of modern breed dogs. In: Science Advances. 2022 ; Vol. 8, No. 16.

Bibtex

@article{d702225161dd490fbe603a5c053a18f4,

title = "The Australian dingo is an early offshoot of modern breed dogs",

abstract = "Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo. ",

author = "Field, {Matt A.} and Sonu Yadav and Olga Dudchenko and Meera Esvaran and Rosen, {Benjamin D.} and Ksenia Skvortsova and Edwards, {Richard J.} and Jens Keilwagen and Cochran, {Blake J.} and Bikash Manandhar and Sonia Bustamante and Rasmussen, {Jacob Agerbo} and Melvin, {Richard G.} and Barry Chernoff and Arina Omer and Zane Colaric and Chan, {Eva K. F.} and Minoche, {Andre E.} and Smith, {Timothy P. L.} and Gilbert, {M. Thomas P.} and Ozren Bogdanovic and Zammit, {Robert A.} and Torsten Thomas and Aiden, {Erez L.} and Ballard, {J. William O.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors.",

year = "2022",

doi = "10.1126/sciadv.abm5944",

language = "English",

volume = "8",

journal = "Science advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "16",

}

RIS

TY - JOUR

T1 - The Australian dingo is an early offshoot of modern breed dogs

AU - Field, Matt A.

AU - Yadav, Sonu

AU - Dudchenko, Olga

AU - Esvaran, Meera

AU - Rosen, Benjamin D.

AU - Skvortsova, Ksenia

AU - Edwards, Richard J.

AU - Keilwagen, Jens

AU - Cochran, Blake J.

AU - Manandhar, Bikash

AU - Bustamante, Sonia

AU - Rasmussen, Jacob Agerbo

AU - Melvin, Richard G.

AU - Chernoff, Barry

AU - Omer, Arina

AU - Colaric, Zane

AU - Chan, Eva K. F.

AU - Minoche, Andre E.

AU - Smith, Timothy P. L.

AU - Gilbert, M. Thomas P.

AU - Bogdanovic, Ozren

AU - Zammit, Robert A.

AU - Thomas, Torsten

AU - Aiden, Erez L.

AU - Ballard, J. William O.

PY - 2022

Y1 - 2022

N2 - Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

AB - Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

U2 - 10.1126/sciadv.abm5944

DO - 10.1126/sciadv.abm5944

M3 - Journal article

C2 - 35452284

AN - SCOPUS:85128884921

VL - 8

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 16

M1 - eabm5944

ER -

ID: 307745688

Globe Institute