Ancient hepatitis B viruses from the Bronze Age to the Medieval period

Research output: Contribution to journal › Letter › Research › peer-review

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Ancient hepatitis B viruses from the Bronze Age to the Medieval period. / Mühlemann, Barbara; Jones, Terry C.; Damgaard, Peter de Barros; Allentoft, Morten Erik; Shevnina, Irina; Logvin, Andrey; Usmanova, Emma; Panyushkina, Irina P.; Boldgiv, Bazartseren; Bazartseren, Tsevel; Tashbaeva, Kadicha; Merz, Victor; Lau, Nina; Smrcka, Vaclav; Voyakin, Dmitry; Kitov, Egor; Epimakhov, Andrey; Pokutta, Dalia; Vicze, Magdolna; Price, T. Douglas; Moiseyev, Vyacheslav; Hansen, Anders Johannes; Orlando, Ludovic Antoine Alexandre; Rasmussen, Simon; Sikora, Martin; Vinner, Lasse; Osterhaus, Albert D. M. E.; Smith, Derek J.; Glebe, Dieter; Fouchier, Ron A. M.; Drosten, Christian; Sjögren, Karl-Goran; Kristiansen, Kristian; Willerslev, Eske.

In: Nature, Vol. 557, No. 7705, 2018, p. 418-423.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Mühlemann, B, Jones, TC, Damgaard, PDB, Allentoft, ME, Shevnina, I, Logvin, A, Usmanova, E, Panyushkina, IP, Boldgiv, B, Bazartseren, T, Tashbaeva, K, Merz, V, Lau, N, Smrcka, V, Voyakin, D, Kitov, E, Epimakhov, A, Pokutta, D, Vicze, M, Price, TD, Moiseyev, V, Hansen, AJ, Orlando, LAA, Rasmussen, S, Sikora, M, Vinner, L, Osterhaus, ADME, Smith, DJ, Glebe, D, Fouchier, RAM, Drosten, C, Sjögren, K-G, Kristiansen, K & Willerslev, E 2018, 'Ancient hepatitis B viruses from the Bronze Age to the Medieval period', Nature, vol. 557, no. 7705, pp. 418-423. https://doi.org/10.1038/s41586-018-0097-z

APA

Mühlemann, B., Jones, T. C., Damgaard, P. D. B., Allentoft, M. E., Shevnina, I., Logvin, A., Usmanova, E., Panyushkina, I. P., Boldgiv, B., Bazartseren, T., Tashbaeva, K., Merz, V., Lau, N., Smrcka, V., Voyakin, D., Kitov, E., Epimakhov, A., Pokutta, D., Vicze, M., ... Willerslev, E. (2018). Ancient hepatitis B viruses from the Bronze Age to the Medieval period. Nature, 557(7705), 418-423. https://doi.org/10.1038/s41586-018-0097-z

Vancouver

Mühlemann B, Jones TC, Damgaard PDB, Allentoft ME, Shevnina I, Logvin A et al. Ancient hepatitis B viruses from the Bronze Age to the Medieval period. Nature. 2018;557(7705):418-423. https://doi.org/10.1038/s41586-018-0097-z

Author

Mühlemann, Barbara ; Jones, Terry C. ; Damgaard, Peter de Barros ; Allentoft, Morten Erik ; Shevnina, Irina ; Logvin, Andrey ; Usmanova, Emma ; Panyushkina, Irina P. ; Boldgiv, Bazartseren ; Bazartseren, Tsevel ; Tashbaeva, Kadicha ; Merz, Victor ; Lau, Nina ; Smrcka, Vaclav ; Voyakin, Dmitry ; Kitov, Egor ; Epimakhov, Andrey ; Pokutta, Dalia ; Vicze, Magdolna ; Price, T. Douglas ; Moiseyev, Vyacheslav ; Hansen, Anders Johannes ; Orlando, Ludovic Antoine Alexandre ; Rasmussen, Simon ; Sikora, Martin ; Vinner, Lasse ; Osterhaus, Albert D. M. E. ; Smith, Derek J. ; Glebe, Dieter ; Fouchier, Ron A. M. ; Drosten, Christian ; Sjögren, Karl-Goran ; Kristiansen, Kristian ; Willerslev, Eske. / Ancient hepatitis B viruses from the Bronze Age to the Medieval period. In: Nature. 2018 ; Vol. 557, No. 7705. pp. 418-423.

Bibtex

@article{b570367fa53b43c4be2c0c78cbbd3870,
title = "Ancient hepatitis B viruses from the Bronze Age to the Medieval period",
abstract = "Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 × 10−6–1.51 × 10−5 nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages1,2. We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.",
author = "Barbara M{\"u}hlemann and Jones, {Terry C.} and Damgaard, {Peter de Barros} and Allentoft, {Morten Erik} and Irina Shevnina and Andrey Logvin and Emma Usmanova and Panyushkina, {Irina P.} and Bazartseren Boldgiv and Tsevel Bazartseren and Kadicha Tashbaeva and Victor Merz and Nina Lau and Vaclav Smrcka and Dmitry Voyakin and Egor Kitov and Andrey Epimakhov and Dalia Pokutta and Magdolna Vicze and Price, {T. Douglas} and Vyacheslav Moiseyev and Hansen, {Anders Johannes} and Orlando, {Ludovic Antoine Alexandre} and Simon Rasmussen and Martin Sikora and Lasse Vinner and Osterhaus, {Albert D. M. E.} and Smith, {Derek J.} and Dieter Glebe and Fouchier, {Ron A. M.} and Christian Drosten and Karl-Goran Sj{\"o}gren and Kristian Kristiansen and Eske Willerslev",
note = "Author Correction: Ancient hepatitis B viruses from the Bronze Age to the Medieval period",
year = "2018",
doi = "10.1038/s41586-018-0097-z",
language = "English",
volume = "557",
pages = "418--423",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7705",

}

RIS

TY - JOUR

T1 - Ancient hepatitis B viruses from the Bronze Age to the Medieval period

AU - Mühlemann, Barbara

AU - Jones, Terry C.

AU - Damgaard, Peter de Barros

AU - Allentoft, Morten Erik

AU - Shevnina, Irina

AU - Logvin, Andrey

AU - Usmanova, Emma

AU - Panyushkina, Irina P.

AU - Boldgiv, Bazartseren

AU - Bazartseren, Tsevel

AU - Tashbaeva, Kadicha

AU - Merz, Victor

AU - Lau, Nina

AU - Smrcka, Vaclav

AU - Voyakin, Dmitry

AU - Kitov, Egor

AU - Epimakhov, Andrey

AU - Pokutta, Dalia

AU - Vicze, Magdolna

AU - Price, T. Douglas

AU - Moiseyev, Vyacheslav

AU - Hansen, Anders Johannes

AU - Orlando, Ludovic Antoine Alexandre

AU - Rasmussen, Simon

AU - Sikora, Martin

AU - Vinner, Lasse

AU - Osterhaus, Albert D. M. E.

AU - Smith, Derek J.

AU - Glebe, Dieter

AU - Fouchier, Ron A. M.

AU - Drosten, Christian

AU - Sjögren, Karl-Goran

AU - Kristiansen, Kristian

AU - Willerslev, Eske

N1 - Author Correction: Ancient hepatitis B viruses from the Bronze Age to the Medieval period

PY - 2018

Y1 - 2018

N2 - Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 × 10−6–1.51 × 10−5 nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages1,2. We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.

AB - Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 × 10−6–1.51 × 10−5 nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages1,2. We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.

UR - https://doi.org/10.1038/s41586-018-0406-6

U2 - 10.1038/s41586-018-0097-z

DO - 10.1038/s41586-018-0097-z

M3 - Letter

C2 - 29743673

VL - 557

SP - 418

EP - 423

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7705

ER -

ID: 196906011