Greenlandic Inuit show genetic signatures of diet and climate adaptation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Greenlandic Inuit show genetic signatures of diet and climate adaptation. / Fumagalli, Matteo; Moltke, Ida; Grarup, Niels; Racimo, Fernando; Bjerregaard, Peter; Jørgensen, Marit E.; Korneliussen, Thorfinn Sand; Gerbault, Pascale; Skotte, Line; Linneberg, Allan René; Christensen, Cramer; Brandslund, Ivan; Jørgensen, Torben; Huerta-Sánchez, Emilia; Schmidt, Erik Berg; Pedersen, Oluf Borbye; Hansen, Torben; Albrechtsen, Anders; Nielsen, Rasmus.

In: Science (New York, N.Y.), Vol. 349, No. 6254, 2015, p. 1343-1347.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fumagalli, M, Moltke, I, Grarup, N, Racimo, F, Bjerregaard, P, Jørgensen, ME, Korneliussen, TS, Gerbault, P, Skotte, L, Linneberg, AR, Christensen, C, Brandslund, I, Jørgensen, T, Huerta-Sánchez, E, Schmidt, EB, Pedersen, OB, Hansen, T, Albrechtsen, A & Nielsen, R 2015, 'Greenlandic Inuit show genetic signatures of diet and climate adaptation', Science (New York, N.Y.), vol. 349, no. 6254, pp. 1343-1347. https://doi.org/10.1126/science.aab2319

APA

Fumagalli, M., Moltke, I., Grarup, N., Racimo, F., Bjerregaard, P., Jørgensen, M. E., Korneliussen, T. S., Gerbault, P., Skotte, L., Linneberg, A. R., Christensen, C., Brandslund, I., Jørgensen, T., Huerta-Sánchez, E., Schmidt, E. B., Pedersen, O. B., Hansen, T., Albrechtsen, A., & Nielsen, R. (2015). Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science (New York, N.Y.), 349(6254), 1343-1347. https://doi.org/10.1126/science.aab2319

Vancouver

Fumagalli M, Moltke I, Grarup N, Racimo F, Bjerregaard P, Jørgensen ME et al. Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science (New York, N.Y.). 2015;349(6254):1343-1347. https://doi.org/10.1126/science.aab2319

Author

Fumagalli, Matteo ; Moltke, Ida ; Grarup, Niels ; Racimo, Fernando ; Bjerregaard, Peter ; Jørgensen, Marit E. ; Korneliussen, Thorfinn Sand ; Gerbault, Pascale ; Skotte, Line ; Linneberg, Allan René ; Christensen, Cramer ; Brandslund, Ivan ; Jørgensen, Torben ; Huerta-Sánchez, Emilia ; Schmidt, Erik Berg ; Pedersen, Oluf Borbye ; Hansen, Torben ; Albrechtsen, Anders ; Nielsen, Rasmus. / Greenlandic Inuit show genetic signatures of diet and climate adaptation. In: Science (New York, N.Y.). 2015 ; Vol. 349, No. 6254. pp. 1343-1347.

Bibtex

@article{35ea1d6d57e643418df777a233b130b0,
title = "Greenlandic Inuit show genetic signatures of diet and climate adaptation",
abstract = "The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs.",
author = "Matteo Fumagalli and Ida Moltke and Niels Grarup and Fernando Racimo and Peter Bjerregaard and J{\o}rgensen, {Marit E.} and Korneliussen, {Thorfinn Sand} and Pascale Gerbault and Line Skotte and Linneberg, {Allan Ren{\'e}} and Cramer Christensen and Ivan Brandslund and Torben J{\o}rgensen and Emilia Huerta-S{\'a}nchez and Schmidt, {Erik Berg} and Pedersen, {Oluf Borbye} and Torben Hansen and Anders Albrechtsen and Rasmus Nielsen",
note = "Copyright {\textcopyright} 2015, American Association for the Advancement of Science.",
year = "2015",
doi = "10.1126/science.aab2319",
language = "English",
volume = "349",
pages = "1343--1347",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6254",

}

RIS

TY - JOUR

T1 - Greenlandic Inuit show genetic signatures of diet and climate adaptation

AU - Fumagalli, Matteo

AU - Moltke, Ida

AU - Grarup, Niels

AU - Racimo, Fernando

AU - Bjerregaard, Peter

AU - Jørgensen, Marit E.

AU - Korneliussen, Thorfinn Sand

AU - Gerbault, Pascale

AU - Skotte, Line

AU - Linneberg, Allan René

AU - Christensen, Cramer

AU - Brandslund, Ivan

AU - Jørgensen, Torben

AU - Huerta-Sánchez, Emilia

AU - Schmidt, Erik Berg

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

AU - Albrechtsen, Anders

AU - Nielsen, Rasmus

N1 - Copyright © 2015, American Association for the Advancement of Science.

PY - 2015

Y1 - 2015

N2 - The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs.

AB - The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs.

U2 - 10.1126/science.aab2319

DO - 10.1126/science.aab2319

M3 - Journal article

C2 - 26383953

VL - 349

SP - 1343

EP - 1347

JO - Science

JF - Science

SN - 0036-8075

IS - 6254

ER -

ID: 145240801