Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries

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Sequence analysis of HIV-1 isolates from Guinea-Bissau : Selection of vaccine epitopes relevant in both West African and European countries. / Vinner, Lasse; Holmgren, Birgitta; Jensen, Kristoffer J.; Esbjornsson, Joakim; Borggren, Marie; Hentze, Julie L.; Karlsson, Ingrid; Andresen, Betina S; Gram, Gregers J.; Kloverpris, Henrik; Aaby, Peter; da Silva, Zacarias José; Fenyö, Eva-Maria; Fomsgaard, Anders.

In: APMIS, Vol. 119, No. 8, 2011, p. 487-497.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vinner, L, Holmgren, B, Jensen, KJ, Esbjornsson, J, Borggren, M, Hentze, JL, Karlsson, I, Andresen, BS, Gram, GJ, Kloverpris, H, Aaby, P, da Silva, ZJ, Fenyö, E-M & Fomsgaard, A 2011, 'Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries', APMIS, vol. 119, no. 8, pp. 487-497. https://doi.org/10.1111/j.1600-0463.2011.02763.x

APA

Vinner, L., Holmgren, B., Jensen, K. J., Esbjornsson, J., Borggren, M., Hentze, J. L., Karlsson, I., Andresen, B. S., Gram, G. J., Kloverpris, H., Aaby, P., da Silva, Z. J., Fenyö, E-M., & Fomsgaard, A. (2011). Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries. APMIS, 119(8), 487-497. https://doi.org/10.1111/j.1600-0463.2011.02763.x

Vancouver

Vinner L, Holmgren B, Jensen KJ, Esbjornsson J, Borggren M, Hentze JL et al. Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries. APMIS. 2011;119(8):487-497. https://doi.org/10.1111/j.1600-0463.2011.02763.x

Author

Vinner, Lasse ; Holmgren, Birgitta ; Jensen, Kristoffer J. ; Esbjornsson, Joakim ; Borggren, Marie ; Hentze, Julie L. ; Karlsson, Ingrid ; Andresen, Betina S ; Gram, Gregers J. ; Kloverpris, Henrik ; Aaby, Peter ; da Silva, Zacarias José ; Fenyö, Eva-Maria ; Fomsgaard, Anders. / Sequence analysis of HIV-1 isolates from Guinea-Bissau : Selection of vaccine epitopes relevant in both West African and European countries. In: APMIS. 2011 ; Vol. 119, No. 8. pp. 487-497.

Bibtex

@article{f4d94a1ce52c4459b7ee6b1bd8224e8f,
title = "Sequence analysis of HIV-1 isolates from Guinea-Bissau: Selection of vaccine epitopes relevant in both West African and European countries",
abstract = "For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.",
author = "Lasse Vinner and Birgitta Holmgren and Jensen, {Kristoffer J.} and Joakim Esbjornsson and Marie Borggren and Hentze, {Julie L.} and Ingrid Karlsson and Andresen, {Betina S} and Gram, {Gregers J.} and Henrik Kloverpris and Peter Aaby and {da Silva}, {Zacarias Jos{\'e}} and Eva-Maria Feny{\"o} and Anders Fomsgaard",
year = "2011",
doi = "10.1111/j.1600-0463.2011.02763.x",
language = "English",
volume = "119",
pages = "487--497",
journal = "APMIS. Supplementum",
issn = "0903-465X",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Sequence analysis of HIV-1 isolates from Guinea-Bissau

T2 - Selection of vaccine epitopes relevant in both West African and European countries

AU - Vinner, Lasse

AU - Holmgren, Birgitta

AU - Jensen, Kristoffer J.

AU - Esbjornsson, Joakim

AU - Borggren, Marie

AU - Hentze, Julie L.

AU - Karlsson, Ingrid

AU - Andresen, Betina S

AU - Gram, Gregers J.

AU - Kloverpris, Henrik

AU - Aaby, Peter

AU - da Silva, Zacarias José

AU - Fenyö, Eva-Maria

AU - Fomsgaard, Anders

PY - 2011

Y1 - 2011

N2 - For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.

AB - For a CD8 epitope-based vaccine to match different geographic locations, the targeted epitopes for cytotoxic T-lymphocytes (CTLs) must be present in the local circulating HIV-1 strains. Secondly, the vaccine epitopes should match the host population HLA types. We characterized two new HIV-1 isolates from Guinea-Bissau. Also, we have identified 15 subdominant CD8 epitopes representing common HLA super-types theoretically covering most HLA alleles in any population. Herein we demonstrate that the selected vaccine epitopes are well conserved and simultaneously present in sequences from West Africa and Denmark. Use of the selected epitopes will likely ensure ≥10 immune targets in the majority of candidates for experimental therapeutic vaccination in both geographic regions. Our results warrant testing of the selected vaccine epitopes in both geographic locations.

U2 - 10.1111/j.1600-0463.2011.02763.x

DO - 10.1111/j.1600-0463.2011.02763.x

M3 - Journal article

VL - 119

SP - 487

EP - 497

JO - APMIS. Supplementum

JF - APMIS. Supplementum

SN - 0903-465X

IS - 8

ER -

ID: 322492106