A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A towering genome : Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. / Liu, Chang; Gao, Jianbo; Cui, Xinxin; Li, Zhipeng; Chen, Lei; Yuan, Yuan; Zhang, Yaolei; Mei, Liangwei; Zhao, Lan; Cai, Dan; Hu, Mingliang; Zhou, Botong; Li, Zihe; Qin, Tao; Si, Huazhe; Li, Guangyu; Lin, Zeshan; Xu, Yicheng; Zhu, Chenglong; Yin, Yuan; Zhang, Chenzhou; Xu, Wenjie; Li, Qingjie; Wang, Kun; Gilbert, M. Thomas P.; Heller, Rasmus; Wang, Wen; Huang, Jinghui; Qiu, Qiang.

In: Science Advances, Vol. 7, No. 12, eabe9459, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liu, C, Gao, J, Cui, X, Li, Z, Chen, L, Yuan, Y, Zhang, Y, Mei, L, Zhao, L, Cai, D, Hu, M, Zhou, B, Li, Z, Qin, T, Si, H, Li, G, Lin, Z, Xu, Y, Zhu, C, Yin, Y, Zhang, C, Xu, W, Li, Q, Wang, K, Gilbert, MTP, Heller, R, Wang, W, Huang, J & Qiu, Q 2021, 'A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe', Science Advances, vol. 7, no. 12, eabe9459. https://doi.org/10.1126/sciadv.abe9459

APA

Liu, C., Gao, J., Cui, X., Li, Z., Chen, L., Yuan, Y., Zhang, Y., Mei, L., Zhao, L., Cai, D., Hu, M., Zhou, B., Li, Z., Qin, T., Si, H., Li, G., Lin, Z., Xu, Y., Zhu, C., ... Qiu, Q. (2021). A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. Science Advances, 7(12), [eabe9459]. https://doi.org/10.1126/sciadv.abe9459

Vancouver

Liu C, Gao J, Cui X, Li Z, Chen L, Yuan Y et al. A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. Science Advances. 2021;7(12). eabe9459. https://doi.org/10.1126/sciadv.abe9459

Author

Liu, Chang ; Gao, Jianbo ; Cui, Xinxin ; Li, Zhipeng ; Chen, Lei ; Yuan, Yuan ; Zhang, Yaolei ; Mei, Liangwei ; Zhao, Lan ; Cai, Dan ; Hu, Mingliang ; Zhou, Botong ; Li, Zihe ; Qin, Tao ; Si, Huazhe ; Li, Guangyu ; Lin, Zeshan ; Xu, Yicheng ; Zhu, Chenglong ; Yin, Yuan ; Zhang, Chenzhou ; Xu, Wenjie ; Li, Qingjie ; Wang, Kun ; Gilbert, M. Thomas P. ; Heller, Rasmus ; Wang, Wen ; Huang, Jinghui ; Qiu, Qiang. / A towering genome : Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. In: Science Advances. 2021 ; Vol. 7, No. 12.

Bibtex

@article{a478fd5cab3c42e2bc985a708712b862,
title = "A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe",
abstract = "The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.",
author = "Chang Liu and Jianbo Gao and Xinxin Cui and Zhipeng Li and Lei Chen and Yuan Yuan and Yaolei Zhang and Liangwei Mei and Lan Zhao and Dan Cai and Mingliang Hu and Botong Zhou and Zihe Li and Tao Qin and Huazhe Si and Guangyu Li and Zeshan Lin and Yicheng Xu and Chenglong Zhu and Yuan Yin and Chenzhou Zhang and Wenjie Xu and Qingjie Li and Kun Wang and Gilbert, {M. Thomas P.} and Rasmus Heller and Wen Wang and Jinghui Huang and Qiang Qiu",
year = "2021",
doi = "10.1126/sciadv.abe9459",
language = "English",
volume = "7",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "12",

}

RIS

TY - JOUR

T1 - A towering genome

T2 - Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe

AU - Liu, Chang

AU - Gao, Jianbo

AU - Cui, Xinxin

AU - Li, Zhipeng

AU - Chen, Lei

AU - Yuan, Yuan

AU - Zhang, Yaolei

AU - Mei, Liangwei

AU - Zhao, Lan

AU - Cai, Dan

AU - Hu, Mingliang

AU - Zhou, Botong

AU - Li, Zihe

AU - Qin, Tao

AU - Si, Huazhe

AU - Li, Guangyu

AU - Lin, Zeshan

AU - Xu, Yicheng

AU - Zhu, Chenglong

AU - Yin, Yuan

AU - Zhang, Chenzhou

AU - Xu, Wenjie

AU - Li, Qingjie

AU - Wang, Kun

AU - Gilbert, M. Thomas P.

AU - Heller, Rasmus

AU - Wang, Wen

AU - Huang, Jinghui

AU - Qiu, Qiang

PY - 2021

Y1 - 2021

N2 - The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.

AB - The suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.

U2 - 10.1126/sciadv.abe9459

DO - 10.1126/sciadv.abe9459

M3 - Journal article

C2 - 33731352

AN - SCOPUS:85102659159

VL - 7

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 12

M1 - eabe9459

ER -

ID: 260186854