Ancient and modern stickleback genomes reveal the demographic constraints on adaptation
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Ancient and modern stickleback genomes reveal the demographic constraints on adaptation. / Kirch, Melanie; Romundset, Anders; Gilbert, M. Thomas P.; Jones, Felicity C.; Foote, Andrew D.
In: Current Biology, Vol. 31, No. 9, 2021, p. 2027-2036.e8.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Ancient and modern stickleback genomes reveal the demographic constraints on adaptation
AU - Kirch, Melanie
AU - Romundset, Anders
AU - Gilbert, M. Thomas P.
AU - Jones, Felicity C.
AU - Foote, Andrew D.
PY - 2021
Y1 - 2021
N2 - Adaptation is typically studied by comparing modern populations with contrasting environments. Individuals persisting in the ancestral habitat are typically used to represent the ancestral founding population; however, it has been questioned whether these individuals are good proxies for the actual ancestors.(1) To address this, we applied a paleogenomics approach(2) to directly access the ancestral genepool: partially sequencing the genomes of two 11- to 13,000-year-old stickleback recovered from the transitionary layer between marine and freshwater sediments of two Norwegian isolation lakes(3) and comparing them with 30 modern stickleback genomes from the same lakes and adjacent marine fjord, in addition to a global dataset of 20 genomes.(4) The ancient stickleback shared genome-wide ancestry with the modern fjord population, whereas modern lake populations have lost substantial ancestral variation following founder effects, and subsequent drift and selection. Freshwater-adaptive alleles found in one ancient stickleback genome have not risen to high frequency in the present-day population from the same lake. Comparison to the global dataset suggested incomplete adaptation to freshwater in our modern lake populations. Our findings reveal the impact of population bottlenecks in constraining adaptation due to reduced efficacy of selection on standing variation present in founder populations.
AB - Adaptation is typically studied by comparing modern populations with contrasting environments. Individuals persisting in the ancestral habitat are typically used to represent the ancestral founding population; however, it has been questioned whether these individuals are good proxies for the actual ancestors.(1) To address this, we applied a paleogenomics approach(2) to directly access the ancestral genepool: partially sequencing the genomes of two 11- to 13,000-year-old stickleback recovered from the transitionary layer between marine and freshwater sediments of two Norwegian isolation lakes(3) and comparing them with 30 modern stickleback genomes from the same lakes and adjacent marine fjord, in addition to a global dataset of 20 genomes.(4) The ancient stickleback shared genome-wide ancestry with the modern fjord population, whereas modern lake populations have lost substantial ancestral variation following founder effects, and subsequent drift and selection. Freshwater-adaptive alleles found in one ancient stickleback genome have not risen to high frequency in the present-day population from the same lake. Comparison to the global dataset suggested incomplete adaptation to freshwater in our modern lake populations. Our findings reveal the impact of population bottlenecks in constraining adaptation due to reduced efficacy of selection on standing variation present in founder populations.
KW - GENETIC ARCHITECTURE
KW - POPULATION HISTORY
KW - EVOLUTION
KW - ADMIXTURE
KW - DNA
KW - ASSOCIATION
KW - DIVERGENCE
KW - PATTERNS
KW - BASINS
U2 - 10.1016/j.cub.2021.02.027
DO - 10.1016/j.cub.2021.02.027
M3 - Journal article
C2 - 33705715
VL - 31
SP - 2027-2036.e8
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 9
ER -
ID: 272404623