Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures

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Standard

Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures. / Hassenkam, Tue; Jørgensen, Henrik L.; Pedersen, Morten B.; Kourakis, Anette H.; Simonsen, Lene; Lauritzen, Jes B.

In: Micron, Vol. 36, No. 7-8, 2005, p. 681-687.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hassenkam, T, Jørgensen, HL, Pedersen, MB, Kourakis, AH, Simonsen, L & Lauritzen, JB 2005, 'Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures', Micron, vol. 36, no. 7-8, pp. 681-687. https://doi.org/10.1016/j.micron.2005.06.007

APA

Hassenkam, T., Jørgensen, H. L., Pedersen, M. B., Kourakis, A. H., Simonsen, L., & Lauritzen, J. B. (2005). Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures. Micron, 36(7-8), 681-687. https://doi.org/10.1016/j.micron.2005.06.007

Vancouver

Hassenkam T, Jørgensen HL, Pedersen MB, Kourakis AH, Simonsen L, Lauritzen JB. Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures. Micron. 2005;36(7-8):681-687. https://doi.org/10.1016/j.micron.2005.06.007

Author

Hassenkam, Tue ; Jørgensen, Henrik L. ; Pedersen, Morten B. ; Kourakis, Anette H. ; Simonsen, Lene ; Lauritzen, Jes B. / Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures. In: Micron. 2005 ; Vol. 36, No. 7-8. pp. 681-687.

Bibtex

@article{4a8368efb66746f3ad3727a32290b0de,
title = "Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures",
abstract = "AFM images were taken of the exterior surface of a single trabecula, extracted from a human femoral head removed during surgery for a hip fracture in an old women with former fractures. The images showed a dense structure of bundled collagen fibrils banded with 67 nm periodicity. Bundles were seen to run in parallel in layers confirming the collagen structure seen by other techniques. Single collagen fibrils were seen to cross the bundles, thus forming cross-links between neighboring bundles of collagen fibrils. Some of these crossing fibrils did not have the 67 nm band pattern and their dimensions were about half compared to the neighboring collagen fibrils. Very little mineral was found on the surface of the trabecula. An AFM image of a fracture plane was also displayed. The trabecula was extracted from a region close to the hip fracture. However, there were in this case no obvious features in the images that could be linked directly to osteoporosis, but altered collagen banding and collagen protrusions may alter mechanical competence. A path to extensive studies of the nanometer scale structure of bone was demonstrated.",
keywords = "AFM, Atomic Force Microscopy, Bone, Osteoporotic, Ultrastructure",
author = "Tue Hassenkam and J{\o}rgensen, {Henrik L.} and Pedersen, {Morten B.} and Kourakis, {Anette H.} and Lene Simonsen and Lauritzen, {Jes B.}",
note = "Funding Information: Acknowledgment: The Research reported here was kindly supported by the Danish research councils (SNF).",
year = "2005",
doi = "10.1016/j.micron.2005.06.007",
language = "English",
volume = "36",
pages = "681--687",
journal = "Micron",
issn = "0968-4328",
publisher = "Pergamon Press",
number = "7-8",

}

RIS

TY - JOUR

T1 - Atomic force microscopy on human trabecular bone from an old woman with osteoporotic fractures

AU - Hassenkam, Tue

AU - Jørgensen, Henrik L.

AU - Pedersen, Morten B.

AU - Kourakis, Anette H.

AU - Simonsen, Lene

AU - Lauritzen, Jes B.

N1 - Funding Information: Acknowledgment: The Research reported here was kindly supported by the Danish research councils (SNF).

PY - 2005

Y1 - 2005

N2 - AFM images were taken of the exterior surface of a single trabecula, extracted from a human femoral head removed during surgery for a hip fracture in an old women with former fractures. The images showed a dense structure of bundled collagen fibrils banded with 67 nm periodicity. Bundles were seen to run in parallel in layers confirming the collagen structure seen by other techniques. Single collagen fibrils were seen to cross the bundles, thus forming cross-links between neighboring bundles of collagen fibrils. Some of these crossing fibrils did not have the 67 nm band pattern and their dimensions were about half compared to the neighboring collagen fibrils. Very little mineral was found on the surface of the trabecula. An AFM image of a fracture plane was also displayed. The trabecula was extracted from a region close to the hip fracture. However, there were in this case no obvious features in the images that could be linked directly to osteoporosis, but altered collagen banding and collagen protrusions may alter mechanical competence. A path to extensive studies of the nanometer scale structure of bone was demonstrated.

AB - AFM images were taken of the exterior surface of a single trabecula, extracted from a human femoral head removed during surgery for a hip fracture in an old women with former fractures. The images showed a dense structure of bundled collagen fibrils banded with 67 nm periodicity. Bundles were seen to run in parallel in layers confirming the collagen structure seen by other techniques. Single collagen fibrils were seen to cross the bundles, thus forming cross-links between neighboring bundles of collagen fibrils. Some of these crossing fibrils did not have the 67 nm band pattern and their dimensions were about half compared to the neighboring collagen fibrils. Very little mineral was found on the surface of the trabecula. An AFM image of a fracture plane was also displayed. The trabecula was extracted from a region close to the hip fracture. However, there were in this case no obvious features in the images that could be linked directly to osteoporosis, but altered collagen banding and collagen protrusions may alter mechanical competence. A path to extensive studies of the nanometer scale structure of bone was demonstrated.

KW - AFM

KW - Atomic Force Microscopy

KW - Bone

KW - Osteoporotic

KW - Ultrastructure

U2 - 10.1016/j.micron.2005.06.007

DO - 10.1016/j.micron.2005.06.007

M3 - Journal article

C2 - 16182551

AN - SCOPUS:28544448373

VL - 36

SP - 681

EP - 687

JO - Micron

JF - Micron

SN - 0968-4328

IS - 7-8

ER -

ID: 288849590