Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). / Xia, Qingyou; Guo, Yiran; Zhang, Ze; Li, Dong; Xuan, Zhaoling; Li, Zhuo; Dai, Fangyin; Li, Yingrui; Cheng, Daojun; Li, Ruiqiang; Cheng, Tingcai; Jiang, Tao; Becquet, Celine; Xu, Xun; Liu, Chun; Zha, Xingfu; Fan, Wei; Lin, Ying; Shen, Yihong; Jiang, Lan; Jensen, Jeffrey; Hellmann, Ines; Tang, Si; Zhao, Ping; Xu, Hanfu; Yu, Chang; Zhang, Guojie; Li, Jun; Cao, Jianjun; Liu, Shiping; He, Ningjia; Zhou, Yan; Liu, Hui; Zhao, Jing; Ye, Chen; Du, Zhouhe; Pan, Guoqing; Zhao, Aichun; Shao, Haojing; Zeng, Wei; Wu, Ping; Li, Chunfeng; Pan, Minhui; Li, Jingjing; Yin, Xuyang; Li, Dawei; Wang, Juan; Zheng, Huisong; Wang, Wen; Zhang, Xiuqing; Li, Songgang; Yang, Huanming; Lu, Cheng; Nielsen, Rasmus; Zhou, Zeyang; Wang, Jian; Xiang, Zhonghuai; Wang, Jun.
In: Science, Vol. 326, No. 5951, 2009, p. 433-6.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx)
AU - Xia, Qingyou
AU - Guo, Yiran
AU - Zhang, Ze
AU - Li, Dong
AU - Xuan, Zhaoling
AU - Li, Zhuo
AU - Dai, Fangyin
AU - Li, Yingrui
AU - Cheng, Daojun
AU - Li, Ruiqiang
AU - Cheng, Tingcai
AU - Jiang, Tao
AU - Becquet, Celine
AU - Xu, Xun
AU - Liu, Chun
AU - Zha, Xingfu
AU - Fan, Wei
AU - Lin, Ying
AU - Shen, Yihong
AU - Jiang, Lan
AU - Jensen, Jeffrey
AU - Hellmann, Ines
AU - Tang, Si
AU - Zhao, Ping
AU - Xu, Hanfu
AU - Yu, Chang
AU - Zhang, Guojie
AU - Li, Jun
AU - Cao, Jianjun
AU - Liu, Shiping
AU - He, Ningjia
AU - Zhou, Yan
AU - Liu, Hui
AU - Zhao, Jing
AU - Ye, Chen
AU - Du, Zhouhe
AU - Pan, Guoqing
AU - Zhao, Aichun
AU - Shao, Haojing
AU - Zeng, Wei
AU - Wu, Ping
AU - Li, Chunfeng
AU - Pan, Minhui
AU - Li, Jingjing
AU - Yin, Xuyang
AU - Li, Dawei
AU - Wang, Juan
AU - Zheng, Huisong
AU - Wang, Wen
AU - Zhang, Xiuqing
AU - Li, Songgang
AU - Yang, Huanming
AU - Lu, Cheng
AU - Nielsen, Rasmus
AU - Zhou, Zeyang
AU - Wang, Jian
AU - Xiang, Zhonghuai
AU - Wang, Jun
N1 - Keywords: Animals; Bombyx; Digestive System; Exocrine Glands; Female; Gene Expression; Genes, Insect; Genetic Variation; Genome, Insect; INDEL Mutation; Linkage Disequilibrium; Male; Phylogeny; Polymorphism, Single Nucleotide; Principal Component Analysis; Selection, Genetic; Sequence Analysis, DNA; Testis
PY - 2009
Y1 - 2009
N2 - A single-base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms, each sequenced to approximately threefold coverage, representing 99.88% of the genome. We identified ~16 million single-nucleotide polymorphisms, many indels, and structural variations. We find that the domesticated silkworms are clearly genetically differentiated from the wild ones, but they have maintained large levels of genetic variability, suggesting a short domestication event involving a large number of individuals. We also identified signals of selection at 354 candidate genes that may have been important during domestication, some of which have enriched expression in the silk gland, midgut, and testis. These data add to our understanding of the domestication processes and may have applications in devising pest control strategies and advancing the use of silkworms as efficient bioreactors.
AB - A single-base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms, each sequenced to approximately threefold coverage, representing 99.88% of the genome. We identified ~16 million single-nucleotide polymorphisms, many indels, and structural variations. We find that the domesticated silkworms are clearly genetically differentiated from the wild ones, but they have maintained large levels of genetic variability, suggesting a short domestication event involving a large number of individuals. We also identified signals of selection at 354 candidate genes that may have been important during domestication, some of which have enriched expression in the silk gland, midgut, and testis. These data add to our understanding of the domestication processes and may have applications in devising pest control strategies and advancing the use of silkworms as efficient bioreactors.
U2 - 10.1126/science.1176620
DO - 10.1126/science.1176620
M3 - Journal article
C2 - 19713493
VL - 326
SP - 433
EP - 436
JO - Science
JF - Science
SN - 0036-8075
IS - 5951
ER -
ID: 21332961