Convergent transcriptional specializations in the brains of humans and song-learning birds

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Convergent transcriptional specializations in the brains of humans and song-learning birds. / Pfenning, Andreas R.; Hara, Erina; Whitney, Osceola; Rivas, Miriam V.; Wang, Rui; Roulhac, Petra L.; Howard, Jason T.; Wirthlin, Morgan; Lovell, Peter V.; Ganapathy, Ganeshkumar; Mouncastle, Jacquelyn; Moseley, M. Arthur; Thompson, J. Will; Soderblom, Erik J.; Iriki, Atsushi; Kato, Masaki; Gilbert, M. Thomas P.; Zhang, Guojie; Bakken, Trygve; Bongaarts, Angie; Bernard, Amy; Lein, Ed; Mello, Claudio V.; Hartemink, Alexander J.; Jarvis, Erich D.

In: Science, Vol. 346, No. 6215, 2014.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pfenning, AR, Hara, E, Whitney, O, Rivas, MV, Wang, R, Roulhac, PL, Howard, JT, Wirthlin, M, Lovell, PV, Ganapathy, G, Mouncastle, J, Moseley, MA, Thompson, JW, Soderblom, EJ, Iriki, A, Kato, M, Gilbert, MTP, Zhang, G, Bakken, T, Bongaarts, A, Bernard, A, Lein, E, Mello, CV, Hartemink, AJ & Jarvis, ED 2014, 'Convergent transcriptional specializations in the brains of humans and song-learning birds', Science, vol. 346, no. 6215. https://doi.org/10.1126/science.1256846

APA

Pfenning, A. R., Hara, E., Whitney, O., Rivas, M. V., Wang, R., Roulhac, P. L., Howard, J. T., Wirthlin, M., Lovell, P. V., Ganapathy, G., Mouncastle, J., Moseley, M. A., Thompson, J. W., Soderblom, E. J., Iriki, A., Kato, M., Gilbert, M. T. P., Zhang, G., Bakken, T., ... Jarvis, E. D. (2014). Convergent transcriptional specializations in the brains of humans and song-learning birds. Science, 346(6215). https://doi.org/10.1126/science.1256846

Vancouver

Pfenning AR, Hara E, Whitney O, Rivas MV, Wang R, Roulhac PL et al. Convergent transcriptional specializations in the brains of humans and song-learning birds. Science. 2014;346(6215). https://doi.org/10.1126/science.1256846

Author

Pfenning, Andreas R. ; Hara, Erina ; Whitney, Osceola ; Rivas, Miriam V. ; Wang, Rui ; Roulhac, Petra L. ; Howard, Jason T. ; Wirthlin, Morgan ; Lovell, Peter V. ; Ganapathy, Ganeshkumar ; Mouncastle, Jacquelyn ; Moseley, M. Arthur ; Thompson, J. Will ; Soderblom, Erik J. ; Iriki, Atsushi ; Kato, Masaki ; Gilbert, M. Thomas P. ; Zhang, Guojie ; Bakken, Trygve ; Bongaarts, Angie ; Bernard, Amy ; Lein, Ed ; Mello, Claudio V. ; Hartemink, Alexander J. ; Jarvis, Erich D. / Convergent transcriptional specializations in the brains of humans and song-learning birds. In: Science. 2014 ; Vol. 346, No. 6215.

Bibtex

@article{881e5c800b664420a845a388aa13538d,
title = "Convergent transcriptional specializations in the brains of humans and song-learning birds",
abstract = "Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.",
author = "Pfenning, {Andreas R.} and Erina Hara and Osceola Whitney and Rivas, {Miriam V.} and Rui Wang and Roulhac, {Petra L.} and Howard, {Jason T.} and Morgan Wirthlin and Lovell, {Peter V.} and Ganeshkumar Ganapathy and Jacquelyn Mouncastle and Moseley, {M. Arthur} and Thompson, {J. Will} and Soderblom, {Erik J.} and Atsushi Iriki and Masaki Kato and Gilbert, {M. Thomas P.} and Guojie Zhang and Trygve Bakken and Angie Bongaarts and Amy Bernard and Ed Lein and Mello, {Claudio V.} and Hartemink, {Alexander J.} and Jarvis, {Erich D.}",
year = "2014",
doi = "10.1126/science.1256846",
language = "English",
volume = "346",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6215",

}

RIS

TY - JOUR

T1 - Convergent transcriptional specializations in the brains of humans and song-learning birds

AU - Pfenning, Andreas R.

AU - Hara, Erina

AU - Whitney, Osceola

AU - Rivas, Miriam V.

AU - Wang, Rui

AU - Roulhac, Petra L.

AU - Howard, Jason T.

AU - Wirthlin, Morgan

AU - Lovell, Peter V.

AU - Ganapathy, Ganeshkumar

AU - Mouncastle, Jacquelyn

AU - Moseley, M. Arthur

AU - Thompson, J. Will

AU - Soderblom, Erik J.

AU - Iriki, Atsushi

AU - Kato, Masaki

AU - Gilbert, M. Thomas P.

AU - Zhang, Guojie

AU - Bakken, Trygve

AU - Bongaarts, Angie

AU - Bernard, Amy

AU - Lein, Ed

AU - Mello, Claudio V.

AU - Hartemink, Alexander J.

AU - Jarvis, Erich D.

PY - 2014

Y1 - 2014

N2 - Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.

AB - Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.

U2 - 10.1126/science.1256846

DO - 10.1126/science.1256846

M3 - Journal article

C2 - 25504733

AN - SCOPUS:84917671664

VL - 346

JO - Science

JF - Science

SN - 0036-8075

IS - 6215

ER -

ID: 129541414