Costs and benefits of mutational robustness in RNA viruses

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Costs and benefits of mutational robustness in RNA viruses. / Stern, Adi; Bianco, Simone; Yeh, Ming Te; Wright, Caroline; Butcher, Kristin; Tang, Chao; Nielsen, Rasmus; Andino, Raul.

In: Cell Reports, Vol. 8, No. 4, 2014, p. 1026-1036.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stern, A, Bianco, S, Yeh, MT, Wright, C, Butcher, K, Tang, C, Nielsen, R & Andino, R 2014, 'Costs and benefits of mutational robustness in RNA viruses', Cell Reports, vol. 8, no. 4, pp. 1026-1036. https://doi.org/10.1016/j.celrep.2014.07.011

APA

Stern, A., Bianco, S., Yeh, M. T., Wright, C., Butcher, K., Tang, C., Nielsen, R., & Andino, R. (2014). Costs and benefits of mutational robustness in RNA viruses. Cell Reports, 8(4), 1026-1036. https://doi.org/10.1016/j.celrep.2014.07.011

Vancouver

Stern A, Bianco S, Yeh MT, Wright C, Butcher K, Tang C et al. Costs and benefits of mutational robustness in RNA viruses. Cell Reports. 2014;8(4):1026-1036. https://doi.org/10.1016/j.celrep.2014.07.011

Author

Stern, Adi ; Bianco, Simone ; Yeh, Ming Te ; Wright, Caroline ; Butcher, Kristin ; Tang, Chao ; Nielsen, Rasmus ; Andino, Raul. / Costs and benefits of mutational robustness in RNA viruses. In: Cell Reports. 2014 ; Vol. 8, No. 4. pp. 1026-1036.

Bibtex

@article{90fbc5eab2bf459583b4d321cc76e164,
title = "Costs and benefits of mutational robustness in RNA viruses",
abstract = "The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations.",
author = "Adi Stern and Simone Bianco and Yeh, {Ming Te} and Caroline Wright and Kristin Butcher and Chao Tang and Rasmus Nielsen and Raul Andino",
year = "2014",
doi = "10.1016/j.celrep.2014.07.011",
language = "English",
volume = "8",
pages = "1026--1036",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Costs and benefits of mutational robustness in RNA viruses

AU - Stern, Adi

AU - Bianco, Simone

AU - Yeh, Ming Te

AU - Wright, Caroline

AU - Butcher, Kristin

AU - Tang, Chao

AU - Nielsen, Rasmus

AU - Andino, Raul

PY - 2014

Y1 - 2014

N2 - The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations.

AB - The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations.

U2 - 10.1016/j.celrep.2014.07.011

DO - 10.1016/j.celrep.2014.07.011

M3 - Journal article

C2 - 25127138

AN - SCOPUS:84908357284

VL - 8

SP - 1026

EP - 1036

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 4

ER -

ID: 222642500