Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. / Hernandez, Ryan D; Hubisz, Melissa J; Wheeler, David A; Smith, David G; Ferguson, Betsy; Rogers, Jeffrey; Nazareth, Lynne; Indap, Amit; Bourquin, Traci; McPherson, John; Muzny, Donna; Gibbs, Richard; Nielsen, Rasmus; Bustamante, Carlos D.

In: Science, Vol. 316, No. 5822, 2007, p. 240-3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hernandez, RD, Hubisz, MJ, Wheeler, DA, Smith, DG, Ferguson, B, Rogers, J, Nazareth, L, Indap, A, Bourquin, T, McPherson, J, Muzny, D, Gibbs, R, Nielsen, R & Bustamante, CD 2007, 'Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques', Science, vol. 316, no. 5822, pp. 240-3. https://doi.org/10.1126/science.1140462

APA

Hernandez, R. D., Hubisz, M. J., Wheeler, D. A., Smith, D. G., Ferguson, B., Rogers, J., Nazareth, L., Indap, A., Bourquin, T., McPherson, J., Muzny, D., Gibbs, R., Nielsen, R., & Bustamante, C. D. (2007). Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. Science, 316(5822), 240-3. https://doi.org/10.1126/science.1140462

Vancouver

Hernandez RD, Hubisz MJ, Wheeler DA, Smith DG, Ferguson B, Rogers J et al. Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. Science. 2007;316(5822):240-3. https://doi.org/10.1126/science.1140462

Author

Hernandez, Ryan D ; Hubisz, Melissa J ; Wheeler, David A ; Smith, David G ; Ferguson, Betsy ; Rogers, Jeffrey ; Nazareth, Lynne ; Indap, Amit ; Bourquin, Traci ; McPherson, John ; Muzny, Donna ; Gibbs, Richard ; Nielsen, Rasmus ; Bustamante, Carlos D. / Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. In: Science. 2007 ; Vol. 316, No. 5822. pp. 240-3.

Bibtex

@article{02bb3810194711deb43e000ea68e967b,
title = "Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques",
abstract = "To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.",
author = "Hernandez, {Ryan D} and Hubisz, {Melissa J} and Wheeler, {David A} and Smith, {David G} and Betsy Ferguson and Jeffrey Rogers and Lynne Nazareth and Amit Indap and Traci Bourquin and John McPherson and Donna Muzny and Richard Gibbs and Rasmus Nielsen and Bustamante, {Carlos D}",
note = "Keywords: Animals; China; DNA, Mitochondrial; Demography; Genetics, Medical; Humans; India; Linkage Disequilibrium; Macaca mulatta; Polymorphism, Single Nucleotide",
year = "2007",
doi = "10.1126/science.1140462",
language = "English",
volume = "316",
pages = "240--3",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5822",

}

RIS

TY - JOUR

T1 - Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques

AU - Hernandez, Ryan D

AU - Hubisz, Melissa J

AU - Wheeler, David A

AU - Smith, David G

AU - Ferguson, Betsy

AU - Rogers, Jeffrey

AU - Nazareth, Lynne

AU - Indap, Amit

AU - Bourquin, Traci

AU - McPherson, John

AU - Muzny, Donna

AU - Gibbs, Richard

AU - Nielsen, Rasmus

AU - Bustamante, Carlos D

N1 - Keywords: Animals; China; DNA, Mitochondrial; Demography; Genetics, Medical; Humans; India; Linkage Disequilibrium; Macaca mulatta; Polymorphism, Single Nucleotide

PY - 2007

Y1 - 2007

N2 - To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.

AB - To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.

U2 - 10.1126/science.1140462

DO - 10.1126/science.1140462

M3 - Journal article

C2 - 17431170

VL - 316

SP - 240

EP - 243

JO - Science

JF - Science

SN - 0036-8075

IS - 5822

ER -

ID: 11529165