Dependence of paracentric inversion rate on tract length

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Standard

Dependence of paracentric inversion rate on tract length. / York, Thomas L; Durrett, Rick; Nielsen, Rasmus.

In: BMC Bioinformatics, Vol. 8, 2007, p. 115.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

York, TL, Durrett, R & Nielsen, R 2007, 'Dependence of paracentric inversion rate on tract length', BMC Bioinformatics, vol. 8, pp. 115. https://doi.org/10.1186/1471-2105-8-115

APA

York, T. L., Durrett, R., & Nielsen, R. (2007). Dependence of paracentric inversion rate on tract length. BMC Bioinformatics, 8, 115. https://doi.org/10.1186/1471-2105-8-115

Vancouver

York TL, Durrett R, Nielsen R. Dependence of paracentric inversion rate on tract length. BMC Bioinformatics. 2007;8:115. https://doi.org/10.1186/1471-2105-8-115

Author

York, Thomas L ; Durrett, Rick ; Nielsen, Rasmus. / Dependence of paracentric inversion rate on tract length. In: BMC Bioinformatics. 2007 ; Vol. 8. pp. 115.

Bibtex

@article{7389b1b0195211deb43e000ea68e967b,
title = "Dependence of paracentric inversion rate on tract length",
abstract = "BACKGROUND: We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species. The method also allows estimation of the distribution of inversion tract lengths. RESULTS: We apply the method to data from Drosophila melanogaster and D. yakuba. We find that pericentric inversions occur at a much lower rate compared to paracentric inversions. The average paracentric inversion tract length is approx. 4.8 Mb with small inversions being more frequent than large inversions.If the two breakpoints defining a paracentric inversion tract are uniformly and independently distributed over chromosome arms there will be more short tract-length inversions than long; we find an even greater preponderance of short tract lengths than this would predict. Thus there appears to be a correlation between the positions of breakpoints which favors shorter tract lengths. CONCLUSION: The method developed in this paper provides the first statistical estimator for estimating the distribution of inversion tract lengths from marker data. Application of this method for a number of data sets may help elucidate the relationship between the length of an inversion and the chance that it will get accepted.",
author = "York, {Thomas L} and Rick Durrett and Rasmus Nielsen",
note = "Keywords: Animals; Chromosome Mapping; Drosophila; Gene Frequency; Genetic Markers; Introns; Inversion, Chromosome",
year = "2007",
doi = "10.1186/1471-2105-8-115",
language = "English",
volume = "8",
pages = "115",
journal = "B M C Bioinformatics",
issn = "1471-2105",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Dependence of paracentric inversion rate on tract length

AU - York, Thomas L

AU - Durrett, Rick

AU - Nielsen, Rasmus

N1 - Keywords: Animals; Chromosome Mapping; Drosophila; Gene Frequency; Genetic Markers; Introns; Inversion, Chromosome

PY - 2007

Y1 - 2007

N2 - BACKGROUND: We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species. The method also allows estimation of the distribution of inversion tract lengths. RESULTS: We apply the method to data from Drosophila melanogaster and D. yakuba. We find that pericentric inversions occur at a much lower rate compared to paracentric inversions. The average paracentric inversion tract length is approx. 4.8 Mb with small inversions being more frequent than large inversions.If the two breakpoints defining a paracentric inversion tract are uniformly and independently distributed over chromosome arms there will be more short tract-length inversions than long; we find an even greater preponderance of short tract lengths than this would predict. Thus there appears to be a correlation between the positions of breakpoints which favors shorter tract lengths. CONCLUSION: The method developed in this paper provides the first statistical estimator for estimating the distribution of inversion tract lengths from marker data. Application of this method for a number of data sets may help elucidate the relationship between the length of an inversion and the chance that it will get accepted.

AB - BACKGROUND: We develop a Bayesian method based on MCMC for estimating the relative rates of pericentric and paracentric inversions from marker data from two species. The method also allows estimation of the distribution of inversion tract lengths. RESULTS: We apply the method to data from Drosophila melanogaster and D. yakuba. We find that pericentric inversions occur at a much lower rate compared to paracentric inversions. The average paracentric inversion tract length is approx. 4.8 Mb with small inversions being more frequent than large inversions.If the two breakpoints defining a paracentric inversion tract are uniformly and independently distributed over chromosome arms there will be more short tract-length inversions than long; we find an even greater preponderance of short tract lengths than this would predict. Thus there appears to be a correlation between the positions of breakpoints which favors shorter tract lengths. CONCLUSION: The method developed in this paper provides the first statistical estimator for estimating the distribution of inversion tract lengths from marker data. Application of this method for a number of data sets may help elucidate the relationship between the length of an inversion and the chance that it will get accepted.

U2 - 10.1186/1471-2105-8-115

DO - 10.1186/1471-2105-8-115

M3 - Journal article

C2 - 17407601

VL - 8

SP - 115

JO - B M C Bioinformatics

JF - B M C Bioinformatics

SN - 1471-2105

ER -

ID: 11529414