Design of association studies with pooled or un-pooled next-generation sequencing data
Research output: Contribution to journal › Journal article › Research › peer-review
Most common hereditary diseases in humans are complex and multifactorial. Large-scale genome-wide association studies based on SNP genotyping have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allele frequency, MAF
| Original language | English |
|---|---|
| Journal | Genetic Epidemiology |
| Volume | 34 |
| Issue number | 5 |
| Pages (from-to) | 479-491 |
| Number of pages | 13 |
| ISSN | 0741-0395 |
| DOIs | |
| Publication status | Published - 2010 |
- Alleles, Chromosome Mapping, Computer Simulation, Denmark, Genetic Predisposition to Disease, Genetic Variation, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Models, Genetic, Models, Statistical, Polymorphism, Single Nucleotide, Research Design, Sequence Analysis, DNA
Research areas
ID: 35312360