Detecting selection needs comparative data

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Detecting selection needs comparative data. / Nielsen, Rasmus; Hubisz, Melissa J.

In: Nature, Vol. 433, No. 7023, 2005, p. E6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, R & Hubisz, MJ 2005, 'Detecting selection needs comparative data', Nature, vol. 433, no. 7023, pp. E6. https://doi.org/10.1038/nature03222

APA

Nielsen, R., & Hubisz, M. J. (2005). Detecting selection needs comparative data. Nature, 433(7023), E6. https://doi.org/10.1038/nature03222

Vancouver

Nielsen R, Hubisz MJ. Detecting selection needs comparative data. Nature. 2005;433(7023):E6. https://doi.org/10.1038/nature03222

Author

Nielsen, Rasmus ; Hubisz, Melissa J. / Detecting selection needs comparative data. In: Nature. 2005 ; Vol. 433, No. 7023. pp. E6.

Bibtex

@article{1f37639074c311dbbee902004c4f4f50,
title = "Detecting selection needs comparative data",
abstract = "Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.",
author = "Rasmus Nielsen and Hubisz, {Melissa J.}",
year = "2005",
doi = "10.1038/nature03222",
language = "English",
volume = "433",
pages = "E6",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7023",

}

RIS

TY - JOUR

T1 - Detecting selection needs comparative data

AU - Nielsen, Rasmus

AU - Hubisz, Melissa J.

PY - 2005

Y1 - 2005

N2 - Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

AB - Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

U2 - 10.1038/nature03222

DO - 10.1038/nature03222

M3 - Journal article

C2 - 15662372

VL - 433

SP - E6

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7023

ER -

ID: 87075