Elevated rates of horizontal gene transfer in the industrialized human microbiome
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Elevated rates of horizontal gene transfer in the industrialized human microbiome. / Groussin, Mathieu; Poyet, Mathilde; Sistiaga, Ainara; Kearney, Sean M.; Moniz, Katya; Noel, Mary; Hooker, Jeff; Gibbons, Sean M.; Segurel, Laure; Froment, Alain; Mohamed, Rihlat Said; Fezeu, Alain; Juimo, Vanessa A.; Lafosse, Sophie; Tabe, Francis E.; Girard, Catherine; Iqaluk, Deborah; Nguyen, Le Thanh Tu; Shapiro, B. Jesse; Lehtimäki, Jenni; Ruokolainen, Lasse; Kettunen, Pinja P.; Vatanen, Tommi; Sigwazi, Shani; Mabulla, Audax; Domínguez-Rodrigo, Manuel; Nartey, Yvonne A.; Agyei-Nkansah, Adwoa; Duah, Amoako; Awuku, Yaw A.; Valles, Kenneth A.; Asibey, Shadrack O.; Afihene, Mary Y.; Roberts, Lewis R.; Plymoth, Amelie; Onyekwere, Charles A.; Summons, Roger E.; Xavier, Ramnik J.; Alm, Eric J.
In: Cell, Vol. 184, No. 8, 2021, p. 2053-2067.e18.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Elevated rates of horizontal gene transfer in the industrialized human microbiome
AU - Groussin, Mathieu
AU - Poyet, Mathilde
AU - Sistiaga, Ainara
AU - Kearney, Sean M.
AU - Moniz, Katya
AU - Noel, Mary
AU - Hooker, Jeff
AU - Gibbons, Sean M.
AU - Segurel, Laure
AU - Froment, Alain
AU - Mohamed, Rihlat Said
AU - Fezeu, Alain
AU - Juimo, Vanessa A.
AU - Lafosse, Sophie
AU - Tabe, Francis E.
AU - Girard, Catherine
AU - Iqaluk, Deborah
AU - Nguyen, Le Thanh Tu
AU - Shapiro, B. Jesse
AU - Lehtimäki, Jenni
AU - Ruokolainen, Lasse
AU - Kettunen, Pinja P.
AU - Vatanen, Tommi
AU - Sigwazi, Shani
AU - Mabulla, Audax
AU - Domínguez-Rodrigo, Manuel
AU - Nartey, Yvonne A.
AU - Agyei-Nkansah, Adwoa
AU - Duah, Amoako
AU - Awuku, Yaw A.
AU - Valles, Kenneth A.
AU - Asibey, Shadrack O.
AU - Afihene, Mary Y.
AU - Roberts, Lewis R.
AU - Plymoth, Amelie
AU - Onyekwere, Charles A.
AU - Summons, Roger E.
AU - Xavier, Ramnik J.
AU - Alm, Eric J.
PY - 2021
Y1 - 2021
N2 - Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.
AB - Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.
KW - antimicrobial resistance
KW - bacterial genomics
KW - culturomics
KW - horizontal gene transfer
KW - host-microbe interactions
KW - human gut microbiome
KW - industrialization
KW - lifestyle
KW - urbanization
KW - virulence
U2 - 10.1016/j.cell.2021.02.052
DO - 10.1016/j.cell.2021.02.052
M3 - Journal article
C2 - 33794144
AN - SCOPUS:85104057213
VL - 184
SP - 2053-2067.e18
JO - Cell
JF - Cell
SN - 0092-8674
IS - 8
ER -
ID: 260547765