Evaluating Neanderthal genetics and phylogeny.

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Evaluating Neanderthal genetics and phylogeny. / Hebsgaard, Martin B; Wiuf, Carsten; Gilbert, M Thomas P; Glenner, Henrik; Willerslev, Eske.

In: Journal of Molecular Evolution, Vol. 64, No. 1, 2007, p. 50-60.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hebsgaard, MB, Wiuf, C, Gilbert, MTP, Glenner, H & Willerslev, E 2007, 'Evaluating Neanderthal genetics and phylogeny.', Journal of Molecular Evolution, vol. 64, no. 1, pp. 50-60. https://doi.org/10.1007/s00239-006-0017-y

APA

Hebsgaard, M. B., Wiuf, C., Gilbert, M. T. P., Glenner, H., & Willerslev, E. (2007). Evaluating Neanderthal genetics and phylogeny. Journal of Molecular Evolution, 64(1), 50-60. https://doi.org/10.1007/s00239-006-0017-y

Vancouver

Hebsgaard MB, Wiuf C, Gilbert MTP, Glenner H, Willerslev E. Evaluating Neanderthal genetics and phylogeny. Journal of Molecular Evolution. 2007;64(1):50-60. https://doi.org/10.1007/s00239-006-0017-y

Author

Hebsgaard, Martin B ; Wiuf, Carsten ; Gilbert, M Thomas P ; Glenner, Henrik ; Willerslev, Eske. / Evaluating Neanderthal genetics and phylogeny. In: Journal of Molecular Evolution. 2007 ; Vol. 64, No. 1. pp. 50-60.

Bibtex

@article{589b6990f80411dcbee902004c4f4f50,
title = "Evaluating Neanderthal genetics and phylogeny.",
abstract = "The retrieval of Neanderthal (Homo neanderthalsensis) mitochondrial DNA is thought to be among the most significant ancient DNA contributions to date, allowing conflicting hypotheses on modern human (Homo sapiens) evolution to be tested directly. Recently, however, both the authenticity of the Neanderthal sequences and their phylogenetic position outside contemporary human diversity have been questioned. Using Bayesian inference and the largest dataset to date, we find strong support for a monophyletic Neanderthal clade outside the diversity of contemporary humans, in agreement with the expectations of the Out-of-Africa replacement model of modern human origin. From average pairwise sequence differences, we obtain support for claims that the first published Neanderthal sequence may include errors due to postmortem damage in the template molecules for PCR. In contrast, we find that recent results implying that the Neanderthal sequences are products of PCR artifacts are not well supported, suffering from inadequate experimental design and a presumably high percentage (>68%) of chimeric sequences due to {"}jumping PCR{"} events.",
author = "Hebsgaard, {Martin B} and Carsten Wiuf and Gilbert, {M Thomas P} and Henrik Glenner and Eske Willerslev",
note = "Keywords: Animals; Artifacts; Bayes Theorem; DNA, Mitochondrial; Hominidae; Humans; Phylogeny; Polymerase Chain Reaction",
year = "2007",
doi = "10.1007/s00239-006-0017-y",
language = "English",
volume = "64",
pages = "50--60",
journal = "Journal of Molecular Evolution",
issn = "0022-2844",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Evaluating Neanderthal genetics and phylogeny.

AU - Hebsgaard, Martin B

AU - Wiuf, Carsten

AU - Gilbert, M Thomas P

AU - Glenner, Henrik

AU - Willerslev, Eske

N1 - Keywords: Animals; Artifacts; Bayes Theorem; DNA, Mitochondrial; Hominidae; Humans; Phylogeny; Polymerase Chain Reaction

PY - 2007

Y1 - 2007

N2 - The retrieval of Neanderthal (Homo neanderthalsensis) mitochondrial DNA is thought to be among the most significant ancient DNA contributions to date, allowing conflicting hypotheses on modern human (Homo sapiens) evolution to be tested directly. Recently, however, both the authenticity of the Neanderthal sequences and their phylogenetic position outside contemporary human diversity have been questioned. Using Bayesian inference and the largest dataset to date, we find strong support for a monophyletic Neanderthal clade outside the diversity of contemporary humans, in agreement with the expectations of the Out-of-Africa replacement model of modern human origin. From average pairwise sequence differences, we obtain support for claims that the first published Neanderthal sequence may include errors due to postmortem damage in the template molecules for PCR. In contrast, we find that recent results implying that the Neanderthal sequences are products of PCR artifacts are not well supported, suffering from inadequate experimental design and a presumably high percentage (>68%) of chimeric sequences due to "jumping PCR" events.

AB - The retrieval of Neanderthal (Homo neanderthalsensis) mitochondrial DNA is thought to be among the most significant ancient DNA contributions to date, allowing conflicting hypotheses on modern human (Homo sapiens) evolution to be tested directly. Recently, however, both the authenticity of the Neanderthal sequences and their phylogenetic position outside contemporary human diversity have been questioned. Using Bayesian inference and the largest dataset to date, we find strong support for a monophyletic Neanderthal clade outside the diversity of contemporary humans, in agreement with the expectations of the Out-of-Africa replacement model of modern human origin. From average pairwise sequence differences, we obtain support for claims that the first published Neanderthal sequence may include errors due to postmortem damage in the template molecules for PCR. In contrast, we find that recent results implying that the Neanderthal sequences are products of PCR artifacts are not well supported, suffering from inadequate experimental design and a presumably high percentage (>68%) of chimeric sequences due to "jumping PCR" events.

U2 - 10.1007/s00239-006-0017-y

DO - 10.1007/s00239-006-0017-y

M3 - Journal article

C2 - 17146600

VL - 64

SP - 50

EP - 60

JO - Journal of Molecular Evolution

JF - Journal of Molecular Evolution

SN - 0022-2844

IS - 1

ER -

ID: 3276340