Evidence for archaic adaptive introgression in humans

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Evidence for archaic adaptive introgression in humans. / Racimo, Fernando; Sankararaman, Sriram; Nielsen, Rasmus; Huerta-Sánchez, Emilia.

In: Nature Reviews Genetics, Vol. 16, No. 6, 18.05.2015, p. 359-371.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Racimo, F, Sankararaman, S, Nielsen, R & Huerta-Sánchez, E 2015, 'Evidence for archaic adaptive introgression in humans', Nature Reviews Genetics, vol. 16, no. 6, pp. 359-371. https://doi.org/10.1038/nrg3936

APA

Racimo, F., Sankararaman, S., Nielsen, R., & Huerta-Sánchez, E. (2015). Evidence for archaic adaptive introgression in humans. Nature Reviews Genetics, 16(6), 359-371. https://doi.org/10.1038/nrg3936

Vancouver

Racimo F, Sankararaman S, Nielsen R, Huerta-Sánchez E. Evidence for archaic adaptive introgression in humans. Nature Reviews Genetics. 2015 May 18;16(6):359-371. https://doi.org/10.1038/nrg3936

Author

Racimo, Fernando ; Sankararaman, Sriram ; Nielsen, Rasmus ; Huerta-Sánchez, Emilia. / Evidence for archaic adaptive introgression in humans. In: Nature Reviews Genetics. 2015 ; Vol. 16, No. 6. pp. 359-371.

Bibtex

@article{cf28dff0a36049b786fe438494ed1acd,
title = "Evidence for archaic adaptive introgression in humans",
abstract = "As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.",
author = "Fernando Racimo and Sriram Sankararaman and Rasmus Nielsen and Emilia Huerta-S{\'a}nchez",
year = "2015",
month = may,
day = "18",
doi = "10.1038/nrg3936",
language = "English",
volume = "16",
pages = "359--371",
journal = "Nature Reviews. Genetics",
issn = "1471-0056",
publisher = "nature publishing group",
number = "6",

}

RIS

TY - JOUR

T1 - Evidence for archaic adaptive introgression in humans

AU - Racimo, Fernando

AU - Sankararaman, Sriram

AU - Nielsen, Rasmus

AU - Huerta-Sánchez, Emilia

PY - 2015/5/18

Y1 - 2015/5/18

N2 - As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.

AB - As modern and ancient DNA sequence data from diverse human populations accumulate, evidence is increasing in support of the existence of beneficial variants acquired from archaic humans that may have accelerated adaptation and improved survival in new environments-a process known as adaptive introgression. Within the past few years, a series of studies have identified genomic regions that show strong evidence for archaic adaptive introgression. Here, we provide an overview of the statistical methods developed to identify archaic introgressed fragments in the genome sequences of modern humans and to determine whether positive selection has acted on these fragments. We review recently reported examples of adaptive introgression, grouped by selection pressure, and consider the level of supporting evidence for each. Finally, we discuss challenges and recommendations for inferring selection on introgressed regions.

UR - http://www.scopus.com/inward/record.url?scp=84929518810&partnerID=8YFLogxK

U2 - 10.1038/nrg3936

DO - 10.1038/nrg3936

M3 - Review

C2 - 25963373

AN - SCOPUS:84929518810

VL - 16

SP - 359

EP - 371

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

IS - 6

ER -

ID: 222642055