Evolution of the germline mutation rate across vertebrates
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Evolution of the germline mutation rate across vertebrates. / Bergeron, Lucie A.; Besenbacher, Søren; Zheng, Jiao; Li, Panyi; Bertelsen, Mads Frost; Quintard, Benoit; Hoffman, Joseph I.; Li, Zhipeng; Leger, Judy St; Shao, Changwei; Stiller, Josefin; Gilbert, M Thomas P; Schierup, Mikkel Heide; Zhang, Guojie.
In: Nature, Vol. 615, 2023, p. 285-291.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evolution of the germline mutation rate across vertebrates
AU - Bergeron, Lucie A.
AU - Besenbacher, Søren
AU - Zheng, Jiao
AU - Li, Panyi
AU - Bertelsen, Mads Frost
AU - Quintard, Benoit
AU - Hoffman, Joseph I.
AU - Li, Zhipeng
AU - Leger, Judy St
AU - Shao, Changwei
AU - Stiller, Josefin
AU - Gilbert, M Thomas P
AU - Schierup, Mikkel Heide
AU - Zhang, Guojie
PY - 2023
Y1 - 2023
N2 - The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself1. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different methodologies2. Here we quantify germline mutation rates across vertebrates by sequencing and comparing the high-coverage genomes of 151 parent–offspring trios from 68 species of mammals, fishes, birds and reptiles. We show that the per-generation mutation rate varies among species by a factor of 40, with mutation rates being higher for males than for females in mammals and birds, but not in reptiles and fishes. The generation time, age at maturity and species-level fecundity are the key life-history traits affecting this variation among species. Furthermore, species with higher long-term effective population sizes tend to have lower mutation rates per generation, providing support for the drift barrier hypothesis3. The exceptionally high yearly mutation rates of domesticated animals, which have been continually selected on fecundity traits including shorter generation times, further support the importance of generation time in the evolution of mutation rates. Overall, our comparative analysis of pedigree-based mutation rates provides ecological insights on the mutation rate evolution in vertebrates.
AB - The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself1. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different methodologies2. Here we quantify germline mutation rates across vertebrates by sequencing and comparing the high-coverage genomes of 151 parent–offspring trios from 68 species of mammals, fishes, birds and reptiles. We show that the per-generation mutation rate varies among species by a factor of 40, with mutation rates being higher for males than for females in mammals and birds, but not in reptiles and fishes. The generation time, age at maturity and species-level fecundity are the key life-history traits affecting this variation among species. Furthermore, species with higher long-term effective population sizes tend to have lower mutation rates per generation, providing support for the drift barrier hypothesis3. The exceptionally high yearly mutation rates of domesticated animals, which have been continually selected on fecundity traits including shorter generation times, further support the importance of generation time in the evolution of mutation rates. Overall, our comparative analysis of pedigree-based mutation rates provides ecological insights on the mutation rate evolution in vertebrates.
U2 - 10.1038/s41586-023-05752-y
DO - 10.1038/s41586-023-05752-y
M3 - Journal article
C2 - 36859541
VL - 615
SP - 285
EP - 291
JO - Nature
JF - Nature
SN - 0028-0836
ER -
ID: 337733330