Fitting the Balding-Nichols model to forensic databases

Research output: Contribution to journal › Journal article › Research › peer-review

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Fitting the Balding-Nichols model to forensic databases. / Rohlfs, Rori V.; Aguiar, Vitor R C; Lohmueller, Kirk E.; Castro, Amanda M.; Ferreira, Alessandro C S; Almeida, Vanessa C O; Louro, Iuri D.; Nielsen, Rasmus.

In: Forensic Science International: Genetics, Vol. 19, 16.07.2015, p. 86-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rohlfs, RV, Aguiar, VRC, Lohmueller, KE, Castro, AM, Ferreira, ACS, Almeida, VCO, Louro, ID & Nielsen, R 2015, 'Fitting the Balding-Nichols model to forensic databases', Forensic Science International: Genetics, vol. 19, pp. 86-91. https://doi.org/10.1016/j.fsigen.2015.05.005

APA

Rohlfs, R. V., Aguiar, V. R. C., Lohmueller, K. E., Castro, A. M., Ferreira, A. C. S., Almeida, V. C. O., Louro, I. D., & Nielsen, R. (2015). Fitting the Balding-Nichols model to forensic databases. Forensic Science International: Genetics, 19, 86-91. https://doi.org/10.1016/j.fsigen.2015.05.005

Vancouver

Rohlfs RV, Aguiar VRC, Lohmueller KE, Castro AM, Ferreira ACS, Almeida VCO et al. Fitting the Balding-Nichols model to forensic databases. Forensic Science International: Genetics. 2015 Jul 16;19:86-91. https://doi.org/10.1016/j.fsigen.2015.05.005

Author

Rohlfs, Rori V. ; Aguiar, Vitor R C ; Lohmueller, Kirk E. ; Castro, Amanda M. ; Ferreira, Alessandro C S ; Almeida, Vanessa C O ; Louro, Iuri D. ; Nielsen, Rasmus. / Fitting the Balding-Nichols model to forensic databases. In: Forensic Science International: Genetics. 2015 ; Vol. 19. pp. 86-91.

Bibtex

@article{0e678cd0bdb949488c05b015c6fef97e,
title = "Fitting the Balding-Nichols model to forensic databases",
abstract = "Large forensic databases provide an opportunity to compare observed empirical rates of genotype matching with those expected under forensic genetic models. A number of researchers have taken advantage of this opportunity to validate some forensic genetic approaches, particularly to ensure that estimated rates of genotype matching between unrelated individuals are indeed slight overestimates of those observed. However, these studies have also revealed systematic error trends in genotype probability estimates. In this analysis, we investigate these error trends and show how they result from inappropriate implementation of the Balding-Nichols model in the context of database-wide matching. Specifically, we show that in addition to accounting for increased allelic matching between individuals with recent shared ancestry, studies must account for relatively decreased allelic matching between individuals with more ancient shared ancestry.",
keywords = "Balding-Nichols model, DNA database, Partial match probability, Population genetics",
author = "Rohlfs, {Rori V.} and Aguiar, {Vitor R C} and Lohmueller, {Kirk E.} and Castro, {Amanda M.} and Ferreira, {Alessandro C S} and Almeida, {Vanessa C O} and Louro, {Iuri D.} and Rasmus Nielsen",
year = "2015",
month = jul,
day = "16",
doi = "10.1016/j.fsigen.2015.05.005",
language = "English",
volume = "19",
pages = "86--91",
journal = "Forensic Science International: Genetics",
issn = "1872-4973",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Fitting the Balding-Nichols model to forensic databases

AU - Rohlfs, Rori V.

AU - Aguiar, Vitor R C

AU - Lohmueller, Kirk E.

AU - Castro, Amanda M.

AU - Ferreira, Alessandro C S

AU - Almeida, Vanessa C O

AU - Louro, Iuri D.

AU - Nielsen, Rasmus

PY - 2015/7/16

Y1 - 2015/7/16

N2 - Large forensic databases provide an opportunity to compare observed empirical rates of genotype matching with those expected under forensic genetic models. A number of researchers have taken advantage of this opportunity to validate some forensic genetic approaches, particularly to ensure that estimated rates of genotype matching between unrelated individuals are indeed slight overestimates of those observed. However, these studies have also revealed systematic error trends in genotype probability estimates. In this analysis, we investigate these error trends and show how they result from inappropriate implementation of the Balding-Nichols model in the context of database-wide matching. Specifically, we show that in addition to accounting for increased allelic matching between individuals with recent shared ancestry, studies must account for relatively decreased allelic matching between individuals with more ancient shared ancestry.

AB - Large forensic databases provide an opportunity to compare observed empirical rates of genotype matching with those expected under forensic genetic models. A number of researchers have taken advantage of this opportunity to validate some forensic genetic approaches, particularly to ensure that estimated rates of genotype matching between unrelated individuals are indeed slight overestimates of those observed. However, these studies have also revealed systematic error trends in genotype probability estimates. In this analysis, we investigate these error trends and show how they result from inappropriate implementation of the Balding-Nichols model in the context of database-wide matching. Specifically, we show that in addition to accounting for increased allelic matching between individuals with recent shared ancestry, studies must account for relatively decreased allelic matching between individuals with more ancient shared ancestry.

KW - Balding-Nichols model

KW - DNA database

KW - Partial match probability

KW - Population genetics

UR - http://www.scopus.com/inward/record.url?scp=84937047025&partnerID=8YFLogxK

U2 - 10.1016/j.fsigen.2015.05.005

DO - 10.1016/j.fsigen.2015.05.005

M3 - Journal article

C2 - 26186694

AN - SCOPUS:84937047025

VL - 19

SP - 86

EP - 91

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

SN - 1872-4973

ER -

ID: 222647936