High Y-chromosomal differentiation among ethnic groups of Dir and Swat districts, Pakistan
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High Y-chromosomal differentiation among ethnic groups of Dir and Swat districts, Pakistan. / Ullah, Inam; Olofsson, Jill K.; Margaryan, Ashot; Ilardo, Melissa; Ahmad, Habib; Sikora, Martin; Hansen, Anders Johannes; Shahid Nadeem, Muhammad; Fazal, Numan; Ali, Murad; Buchard, Anders; Hemphill, Brian E.; Willerslev, Eske; Allentoft, Morten Erik.
In: Annals of Human Genetics, Vol. 81, No. 6, 11.2017, p. 234–248.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High Y-chromosomal differentiation among ethnic groups of Dir and Swat districts, Pakistan
AU - Ullah, Inam
AU - Olofsson, Jill K.
AU - Margaryan, Ashot
AU - Ilardo, Melissa
AU - Ahmad, Habib
AU - Sikora, Martin
AU - Hansen, Anders Johannes
AU - Shahid Nadeem, Muhammad
AU - Fazal, Numan
AU - Ali, Murad
AU - Buchard, Anders
AU - Hemphill, Brian E.
AU - Willerslev, Eske
AU - Allentoft, Morten Erik
N1 - © 2017 John Wiley & Sons Ltd/University College London.
PY - 2017/11
Y1 - 2017/11
N2 - The ethnic groups that inhabit the mountainous Dir and Swat districts of northern Pakistan are marked by high levels of cultural and phenotypic diversity. To obtain knowledge of the extent of genetic diversity in this region, we investigated Y-chromosomal diversity in five population samples representing the three main ethnic groups residing within these districts, including Gujars, Pashtuns and Kohistanis. A total of 27 Y-chromosomal short tandem repeats (Y-STRs) and 331 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) were investigated. In the Y-STRs, we observed very high and significant levels of genetic differentiation in nine of the 10 pairwise between-group comparisons (RST 0.179-0.746), and the differences were mirrored in the Y-SNP haplogroup frequency distribution. No genetic differences were found between the two Pashtun subethnic groups Tarklanis and Yusafzais (RST = 0.000). Utmankhels, also considered Pashtuns culturally, were not closely related to any of the other population samples (RST 0.451-0.746). Thus, our findings provide examples of both associations and dissociations between cultural and genetic legacies. When analyzed within a larger continental-scale context, these five ethnic groups fall mostly outside the previously characterized Y-chromosomal gene pools of the Indo-Pakistani subcontinent. Male founder effects, coupled with culturally and topographically based constraints upon marriage and movement, are likely responsible for the high degree of genetic structure in this region.
AB - The ethnic groups that inhabit the mountainous Dir and Swat districts of northern Pakistan are marked by high levels of cultural and phenotypic diversity. To obtain knowledge of the extent of genetic diversity in this region, we investigated Y-chromosomal diversity in five population samples representing the three main ethnic groups residing within these districts, including Gujars, Pashtuns and Kohistanis. A total of 27 Y-chromosomal short tandem repeats (Y-STRs) and 331 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) were investigated. In the Y-STRs, we observed very high and significant levels of genetic differentiation in nine of the 10 pairwise between-group comparisons (RST 0.179-0.746), and the differences were mirrored in the Y-SNP haplogroup frequency distribution. No genetic differences were found between the two Pashtun subethnic groups Tarklanis and Yusafzais (RST = 0.000). Utmankhels, also considered Pashtuns culturally, were not closely related to any of the other population samples (RST 0.451-0.746). Thus, our findings provide examples of both associations and dissociations between cultural and genetic legacies. When analyzed within a larger continental-scale context, these five ethnic groups fall mostly outside the previously characterized Y-chromosomal gene pools of the Indo-Pakistani subcontinent. Male founder effects, coupled with culturally and topographically based constraints upon marriage and movement, are likely responsible for the high degree of genetic structure in this region.
KW - Journal Article
U2 - 10.1111/ahg.12204
DO - 10.1111/ahg.12204
M3 - Journal article
C2 - 28771684
VL - 81
SP - 234
EP - 248
JO - Annals of Human Genetics
JF - Annals of Human Genetics
SN - 0003-4800
IS - 6
ER -
ID: 181871024