Impact of microbial genome completeness on metagenomic functional inference

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Impact of microbial genome completeness on metagenomic functional inference. / Eisenhofer, Raphael; Odriozola, Iñaki; Alberdi, Antton.

In: ISME communications, Vol. 3, 12, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Eisenhofer, R, Odriozola, I & Alberdi, A 2023, 'Impact of microbial genome completeness on metagenomic functional inference', ISME communications, vol. 3, 12. https://doi.org/10.1038/s43705-023-00221-z

APA

Eisenhofer, R., Odriozola, I., & Alberdi, A. (2023). Impact of microbial genome completeness on metagenomic functional inference. ISME communications, 3, [12]. https://doi.org/10.1038/s43705-023-00221-z

Vancouver

Eisenhofer R, Odriozola I, Alberdi A. Impact of microbial genome completeness on metagenomic functional inference. ISME communications. 2023;3. 12. https://doi.org/10.1038/s43705-023-00221-z

Author

Eisenhofer, Raphael ; Odriozola, Iñaki ; Alberdi, Antton. / Impact of microbial genome completeness on metagenomic functional inference. In: ISME communications. 2023 ; Vol. 3.

Bibtex

@article{88d4479ffbf847cf8ca0cbba922e1a32,

title = "Impact of microbial genome completeness on metagenomic functional inference",

abstract = "Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.",

author = "Raphael Eisenhofer and I{\~n}aki Odriozola and Antton Alberdi",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

doi = "10.1038/s43705-023-00221-z",

language = "English",

volume = "3",

journal = "ISME communications",

issn = "2730-6151",

publisher = "Springer",

}

RIS

TY - JOUR

T1 - Impact of microbial genome completeness on metagenomic functional inference

AU - Eisenhofer, Raphael

AU - Odriozola, Iñaki

AU - Alberdi, Antton

PY - 2023

Y1 - 2023

N2 - Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.

AB - Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.

U2 - 10.1038/s43705-023-00221-z

DO - 10.1038/s43705-023-00221-z

M3 - Journal article

C2 - 36797336

VL - 3

JO - ISME communications

JF - ISME communications

SN - 2730-6151

M1 - 12

ER -

ID: 340706291

Globe Institute