Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium
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Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium. / Brodin, Birger; Rytved, K A; Nielsen, R.
In: Pflügers Archiv - European Journal of Physiology, Vol. 426, No. 1-2, 1994, p. 171-3.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium
AU - Brodin, Birger
AU - Rytved, K A
AU - Nielsen, R
PY - 1994
Y1 - 1994
N2 - Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.
AB - Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.
KW - Animals
KW - Calcium
KW - Cytosol
KW - Epithelium
KW - Indomethacin
KW - Intracellular Fluid
KW - Ion Transport
KW - Membrane Potentials
KW - Permeability
KW - Potassium
KW - Rana temporaria
KW - Skin
M3 - Journal article
C2 - 8146019
VL - 426
SP - 171
EP - 173
JO - Pflügers Archiv - European Journal of Physiology
JF - Pflügers Archiv - European Journal of Physiology
SN - 0031-6768
IS - 1-2
ER -
ID: 37899892