Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling. / Isager Ahl, Louise; Schoeneburg, Mia Prehn; Harth, Lisa; Barnes, Christopher J.; Woetmann, Anders; Rønsted, Nina.

In: Phytomedicine Plus, Vol. 3, No. 1, 100397, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Isager Ahl, L, Schoeneburg, MP, Harth, L, Barnes, CJ, Woetmann, A & Rønsted, N 2023, 'Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling', Phytomedicine Plus, vol. 3, no. 1, 100397. https://doi.org/10.1016/j.phyplu.2022.100397

APA

Isager Ahl, L., Schoeneburg, M. P., Harth, L., Barnes, C. J., Woetmann, A., & Rønsted, N. (2023). Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling. Phytomedicine Plus, 3(1), [100397]. https://doi.org/10.1016/j.phyplu.2022.100397

Vancouver

Isager Ahl L, Schoeneburg MP, Harth L, Barnes CJ, Woetmann A, Rønsted N. Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling. Phytomedicine Plus. 2023;3(1). 100397. https://doi.org/10.1016/j.phyplu.2022.100397

Author

Isager Ahl, Louise ; Schoeneburg, Mia Prehn ; Harth, Lisa ; Barnes, Christopher J. ; Woetmann, Anders ; Rønsted, Nina. / Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling. In: Phytomedicine Plus. 2023 ; Vol. 3, No. 1.

Bibtex

@article{c1bac1c5e5cc400da90610c159b71d7b,
title = "Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling",
abstract = "BackgroundGel extracted from the succulent inner leaf mesophyll of species from the plant genus Aloe have been used in traditional medicine for centuries as a topical treatment for a wide range of skin conditions.Aim of the studyThe aim of this study was to investigate the potential anti-inflammatory properties of leaf gel from 23 different Aloe species. In this study we have focused on the pathways activated by the toll-like receptors TLR4 (activated by LPS), and TLR2/TLR6 (activated by FSL-1) by measuring transcriptional activity of NF-κB.Materials and methodsGel extractions from the inner leaf mesophyll material of 23 different Aloe species, pure acemannan obtained from Aloe vera, and pH. Eur. reference material from Aloe vera and Aloe ferox, were tested on the cell line J774-Dual. NF-κB activity was measured after 24 h.ResultsWe found that 8 out of the 23 tested Aloe gel extracts significantly decreased LPS-induced NF-κB-activity, but no significant effect was seen with FSL-1.ConclusionBased on these findings we can confirm that extracted gel from some of the tested Aloe species but not all, have anti-inflammatory properties.",
author = "{Isager Ahl}, Louise and Schoeneburg, {Mia Prehn} and Lisa Harth and Barnes, {Christopher J.} and Anders Woetmann and Nina R{\o}nsted",
year = "2023",
doi = "10.1016/j.phyplu.2022.100397",
language = "English",
volume = "3",
journal = "Phytomedicine Plus",
issn = "2667-0313",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Leaf gel from several Aloe species shows anti-inflammatory properties through the inhibition of lipopolysaccharide (LPS) mediated activation of Toll-like receptor 4 (TLR4) signaling

AU - Isager Ahl, Louise

AU - Schoeneburg, Mia Prehn

AU - Harth, Lisa

AU - Barnes, Christopher J.

AU - Woetmann, Anders

AU - Rønsted, Nina

PY - 2023

Y1 - 2023

N2 - BackgroundGel extracted from the succulent inner leaf mesophyll of species from the plant genus Aloe have been used in traditional medicine for centuries as a topical treatment for a wide range of skin conditions.Aim of the studyThe aim of this study was to investigate the potential anti-inflammatory properties of leaf gel from 23 different Aloe species. In this study we have focused on the pathways activated by the toll-like receptors TLR4 (activated by LPS), and TLR2/TLR6 (activated by FSL-1) by measuring transcriptional activity of NF-κB.Materials and methodsGel extractions from the inner leaf mesophyll material of 23 different Aloe species, pure acemannan obtained from Aloe vera, and pH. Eur. reference material from Aloe vera and Aloe ferox, were tested on the cell line J774-Dual. NF-κB activity was measured after 24 h.ResultsWe found that 8 out of the 23 tested Aloe gel extracts significantly decreased LPS-induced NF-κB-activity, but no significant effect was seen with FSL-1.ConclusionBased on these findings we can confirm that extracted gel from some of the tested Aloe species but not all, have anti-inflammatory properties.

AB - BackgroundGel extracted from the succulent inner leaf mesophyll of species from the plant genus Aloe have been used in traditional medicine for centuries as a topical treatment for a wide range of skin conditions.Aim of the studyThe aim of this study was to investigate the potential anti-inflammatory properties of leaf gel from 23 different Aloe species. In this study we have focused on the pathways activated by the toll-like receptors TLR4 (activated by LPS), and TLR2/TLR6 (activated by FSL-1) by measuring transcriptional activity of NF-κB.Materials and methodsGel extractions from the inner leaf mesophyll material of 23 different Aloe species, pure acemannan obtained from Aloe vera, and pH. Eur. reference material from Aloe vera and Aloe ferox, were tested on the cell line J774-Dual. NF-κB activity was measured after 24 h.ResultsWe found that 8 out of the 23 tested Aloe gel extracts significantly decreased LPS-induced NF-κB-activity, but no significant effect was seen with FSL-1.ConclusionBased on these findings we can confirm that extracted gel from some of the tested Aloe species but not all, have anti-inflammatory properties.

U2 - 10.1016/j.phyplu.2022.100397

DO - 10.1016/j.phyplu.2022.100397

M3 - Journal article

VL - 3

JO - Phytomedicine Plus

JF - Phytomedicine Plus

SN - 2667-0313

IS - 1

M1 - 100397

ER -

ID: 329636006