Mammals show distinct functional gut microbiome dynamics to identical series of environmental stressors
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Mammals show distinct functional gut microbiome dynamics to identical series of environmental stressors. / Koziol, Adam; Odriozola, Iñaki; Leonard, Aoife; Eisenhofer, Raphael; José, Carlos San; Aizpurua, Ostaizka; Alberdi, Antton.
In: mBio, Vol. 14, No. 5, e01606-23, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Mammals show distinct functional gut microbiome dynamics to identical series of environmental stressors
AU - Koziol, Adam
AU - Odriozola, Iñaki
AU - Leonard, Aoife
AU - Eisenhofer, Raphael
AU - José, Carlos San
AU - Aizpurua, Ostaizka
AU - Alberdi, Antton
N1 - Publisher Copyright: Copyright © 2023 Koziol et al.
PY - 2023
Y1 - 2023
N2 - The ability of the gut microbiome has been posited as an additional axis of animals’ phenotypic plasticity. However, whether and how such plasticity varies across hosts with different biological features remains unclear. We performed a captivity experiment to compare how the taxonomic, phylogenetic, and functional microbial dynamics varied across a series of temperature and dietary disturbances in two mammals: the insectivorous-specialist Crocidura russula and the omnivorous-generalist Apodemus sylvaticus. Combining genome-resolved metagenomics, metabolic pathway distillation and joint species distribution modeling, we observed that, although microbiome alpha diversity of both species remained stable, C. russula exhibited substantially higher variability and directionality of microbial responses than A. sylvaticus. Our results indicate that the intrinsic properties (e.g., diversity and functional redundancy) of microbial communities coupled with physiological attributes (e.g., thermal plasticity) of hosts shape the taxonomic, phylogenetic, and functional response of gut microbiomes to environmental stressors, which might influence their contribution to the acclimation and adaptation capacity of animal hosts. IMPORTANCE In our manuscript, we report the first interspecific comparative study about the plasticity of the gut microbiota. We conducted a captivity experiment that exposed wild-captured mammals to a series of environmental challenges over 45 days. We characterized their gut microbial communities using genome-resolved metagenomics and modeled how the taxonomic, phylogenetic, and functional microbial dynamics varied across a series of disturbances in both species. Our results indicate that the intrinsic properties (e.g., diversity and functional redundancy) of microbial communities coupled with physiological attributes (e.g., thermal plasticity) of hosts shape the taxonomic, phylogenetic, and functional response of gut microbiomes to environmental stressors, which might influence their contribution to the acclimation and adaptation capacity of animal hosts.
AB - The ability of the gut microbiome has been posited as an additional axis of animals’ phenotypic plasticity. However, whether and how such plasticity varies across hosts with different biological features remains unclear. We performed a captivity experiment to compare how the taxonomic, phylogenetic, and functional microbial dynamics varied across a series of temperature and dietary disturbances in two mammals: the insectivorous-specialist Crocidura russula and the omnivorous-generalist Apodemus sylvaticus. Combining genome-resolved metagenomics, metabolic pathway distillation and joint species distribution modeling, we observed that, although microbiome alpha diversity of both species remained stable, C. russula exhibited substantially higher variability and directionality of microbial responses than A. sylvaticus. Our results indicate that the intrinsic properties (e.g., diversity and functional redundancy) of microbial communities coupled with physiological attributes (e.g., thermal plasticity) of hosts shape the taxonomic, phylogenetic, and functional response of gut microbiomes to environmental stressors, which might influence their contribution to the acclimation and adaptation capacity of animal hosts. IMPORTANCE In our manuscript, we report the first interspecific comparative study about the plasticity of the gut microbiota. We conducted a captivity experiment that exposed wild-captured mammals to a series of environmental challenges over 45 days. We characterized their gut microbial communities using genome-resolved metagenomics and modeled how the taxonomic, phylogenetic, and functional microbial dynamics varied across a series of disturbances in both species. Our results indicate that the intrinsic properties (e.g., diversity and functional redundancy) of microbial communities coupled with physiological attributes (e.g., thermal plasticity) of hosts shape the taxonomic, phylogenetic, and functional response of gut microbiomes to environmental stressors, which might influence their contribution to the acclimation and adaptation capacity of animal hosts.
KW - acclimation
KW - adaptation
KW - apodemus
KW - beta diversity
KW - crocidura
U2 - 10.1128/mbio.01606-23
DO - 10.1128/mbio.01606-23
M3 - Journal article
C2 - 37650630
AN - SCOPUS:85176739562
VL - 14
JO - mBio
JF - mBio
SN - 2161-2129
IS - 5
M1 - e01606-23
ER -
ID: 374453711