Molecular Signatures of Natural Selection
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Molecular Signatures of Natural Selection. / Nielsen, Rasmus.
In: Annual Review of Genetics, Vol. 39, 2005, p. 197-218.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecular Signatures of Natural Selection
AU - Nielsen, Rasmus
PY - 2005
Y1 - 2005
N2 - There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
AB - There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
U2 - 10.1146/annurev.genet.39.073003.112420
DO - 10.1146/annurev.genet.39.073003.112420
M3 - Journal article
C2 - 16285858
VL - 39
SP - 197
EP - 218
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -
ID: 87794