Pervasive introgression facilitated domestication and adaptation in the Bos species complex
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Pervasive introgression facilitated domestication and adaptation in the Bos species complex. / Wu, Dong-Dong; Ding, Xiang Dong; Wang, Sheng; Wójcik, Jan M.; Zhang, Yi; Tokarska, Małgorzata; Li, Yan; Wang, Ming Shan; Faruque, Omar; Nielsen, Rasmus; Zhang, Qin; Zhang, Ya-Ping.
In: Nature Ecology and Evolution, Vol. 2, No. 7, 2018, p. 1139-1145.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pervasive introgression facilitated domestication and adaptation in the Bos species complex
AU - Wu, Dong-Dong
AU - Ding, Xiang Dong
AU - Wang, Sheng
AU - Wójcik, Jan M.
AU - Zhang, Yi
AU - Tokarska, Małgorzata
AU - Li, Yan
AU - Wang, Ming Shan
AU - Faruque, Omar
AU - Nielsen, Rasmus
AU - Zhang, Qin
AU - Zhang, Ya-Ping
PY - 2018
Y1 - 2018
N2 - Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.
AB - Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.
U2 - 10.1038/s41559-018-0562-y
DO - 10.1038/s41559-018-0562-y
M3 - Journal article
C2 - 29784979
AN - SCOPUS:85047179716
VL - 2
SP - 1139
EP - 1145
JO - Nature Ecology & Evolution
JF - Nature Ecology & Evolution
SN - 2397-334X
IS - 7
ER -
ID: 222568140