Population genomics of the muskox' resilience in the near absence of genetic variation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Population genomics of the muskox' resilience in the near absence of genetic variation. / Pečnerová, Patrícia; Lord, Edana; Garcia-Erill, Genís; Hanghøj, Kristian; Rasmussen, Malthe Sebro; Meisner, Jonas; Liu, Xiaodong; van der Valk, Tom; Santander, Cindy G.; Quinn, Liam; Lin, Long; Liu, Shanlin; Carøe, Christian; Dalerum, Fredrik; Götherström, Anders; Måsviken, Johannes; Vartanyan, Sergey; Raundrup, Katrine; Al-Chaer, Amal; Rasmussen, Linett; Hvilsom, Christina; Heide-Jørgensen, Mads Peter; Sinding, Mikkel Holger S.; Aastrup, Peter; Van Coeverden de Groot, Peter J.; Schmidt, Niels Martin; Albrechtsen, Anders; Dalén, Love; Heller, Rasmus; Moltke, Ida; Siegismund, Hans Redlef.

In: Molecular Ecology, Vol. 33, No. 2, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pečnerová, P, Lord, E, Garcia-Erill, G, Hanghøj, K, Rasmussen, MS, Meisner, J, Liu, X, van der Valk, T, Santander, CG, Quinn, L, Lin, L, Liu, S, Carøe, C, Dalerum, F, Götherström, A, Måsviken, J, Vartanyan, S, Raundrup, K, Al-Chaer, A, Rasmussen, L, Hvilsom, C, Heide-Jørgensen, MP, Sinding, MHS, Aastrup, P, Van Coeverden de Groot, PJ, Schmidt, NM, Albrechtsen, A, Dalén, L, Heller, R, Moltke, I & Siegismund, HR 2024, 'Population genomics of the muskox' resilience in the near absence of genetic variation', Molecular Ecology, vol. 33, no. 2. https://doi.org/10.1111/mec.17205

APA

Pečnerová, P., Lord, E., Garcia-Erill, G., Hanghøj, K., Rasmussen, M. S., Meisner, J., Liu, X., van der Valk, T., Santander, C. G., Quinn, L., Lin, L., Liu, S., Carøe, C., Dalerum, F., Götherström, A., Måsviken, J., Vartanyan, S., Raundrup, K., Al-Chaer, A., ... Siegismund, H. R. (2024). Population genomics of the muskox' resilience in the near absence of genetic variation. Molecular Ecology, 33(2). https://doi.org/10.1111/mec.17205

Vancouver

Pečnerová P, Lord E, Garcia-Erill G, Hanghøj K, Rasmussen MS, Meisner J et al. Population genomics of the muskox' resilience in the near absence of genetic variation. Molecular Ecology. 2024;33(2). https://doi.org/10.1111/mec.17205

Author

Pečnerová, Patrícia ; Lord, Edana ; Garcia-Erill, Genís ; Hanghøj, Kristian ; Rasmussen, Malthe Sebro ; Meisner, Jonas ; Liu, Xiaodong ; van der Valk, Tom ; Santander, Cindy G. ; Quinn, Liam ; Lin, Long ; Liu, Shanlin ; Carøe, Christian ; Dalerum, Fredrik ; Götherström, Anders ; Måsviken, Johannes ; Vartanyan, Sergey ; Raundrup, Katrine ; Al-Chaer, Amal ; Rasmussen, Linett ; Hvilsom, Christina ; Heide-Jørgensen, Mads Peter ; Sinding, Mikkel Holger S. ; Aastrup, Peter ; Van Coeverden de Groot, Peter J. ; Schmidt, Niels Martin ; Albrechtsen, Anders ; Dalén, Love ; Heller, Rasmus ; Moltke, Ida ; Siegismund, Hans Redlef. / Population genomics of the muskox' resilience in the near absence of genetic variation. In: Molecular Ecology. 2024 ; Vol. 33, No. 2.

Bibtex

@article{53fd9f105cf8475499fd734455e90975,
title = "Population genomics of the muskox' resilience in the near absence of genetic variation",
abstract = "Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox (Ovibos moschatus), an Ice Age relict that was at the brink of extinction for thousands of years at the end of the Pleistocene yet appears to be thriving today. We analysed 108 whole genomes, including present-day individuals representing the current native range of both muskox subspecies, the white-faced and the barren-ground muskox (O. moschatus wardi and O. moschatus moschatus) and a ~21,000-year-old ancient individual from Siberia. We found that the muskox' demographic history was profoundly shaped by past climate changes and post-glacial re-colonizations. In particular, the white-faced muskox has the lowest genome-wide heterozygosity recorded in an ungulate. Yet, there is no evidence of inbreeding depression in native muskox populations. We hypothesize that this can be explained by the effect of long-term gradual population declines that allowed for purging of strongly deleterious mutations. This study provides insights into how species with a history of population bottlenecks, small population sizes and low genetic diversity survive against all odds.",
keywords = "ancient DNA, genetic diversity, genetic load, inbreeding, muskox, population genomics",
author = "Patr{\'i}cia Pe{\v c}nerov{\'a} and Edana Lord and Gen{\'i}s Garcia-Erill and Kristian Hangh{\o}j and Rasmussen, {Malthe Sebro} and Jonas Meisner and Xiaodong Liu and Tom van der Valk and Santander, {Cindy G.} and Liam Quinn and Long Lin and Shanlin Liu and Christian Car{\o}e and Fredrik Dalerum and Anders G{\"o}therstr{\"o}m and Johannes M{\aa}sviken and Sergey Vartanyan and Katrine Raundrup and Amal Al-Chaer and Linett Rasmussen and Christina Hvilsom and Heide-J{\o}rgensen, {Mads Peter} and Sinding, {Mikkel Holger S.} and Peter Aastrup and Van Coeverden de Groot, {Peter J.} and Schmidt, {Niels Martin} and Anders Albrechtsen and Love Dal{\'e}n and Rasmus Heller and Ida Moltke and Siegismund, {Hans Redlef}",
note = "Publisher Copyright: {\textcopyright} 2023 John Wiley & Sons Ltd.",
year = "2024",
doi = "10.1111/mec.17205",
language = "English",
volume = "33",
journal = "Molecular Ecology",
issn = "0962-1083",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Population genomics of the muskox' resilience in the near absence of genetic variation

AU - Pečnerová, Patrícia

AU - Lord, Edana

AU - Garcia-Erill, Genís

AU - Hanghøj, Kristian

AU - Rasmussen, Malthe Sebro

AU - Meisner, Jonas

AU - Liu, Xiaodong

AU - van der Valk, Tom

AU - Santander, Cindy G.

AU - Quinn, Liam

AU - Lin, Long

AU - Liu, Shanlin

AU - Carøe, Christian

AU - Dalerum, Fredrik

AU - Götherström, Anders

AU - Måsviken, Johannes

AU - Vartanyan, Sergey

AU - Raundrup, Katrine

AU - Al-Chaer, Amal

AU - Rasmussen, Linett

AU - Hvilsom, Christina

AU - Heide-Jørgensen, Mads Peter

AU - Sinding, Mikkel Holger S.

AU - Aastrup, Peter

AU - Van Coeverden de Groot, Peter J.

AU - Schmidt, Niels Martin

AU - Albrechtsen, Anders

AU - Dalén, Love

AU - Heller, Rasmus

AU - Moltke, Ida

AU - Siegismund, Hans Redlef

N1 - Publisher Copyright: © 2023 John Wiley & Sons Ltd.

PY - 2024

Y1 - 2024

N2 - Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox (Ovibos moschatus), an Ice Age relict that was at the brink of extinction for thousands of years at the end of the Pleistocene yet appears to be thriving today. We analysed 108 whole genomes, including present-day individuals representing the current native range of both muskox subspecies, the white-faced and the barren-ground muskox (O. moschatus wardi and O. moschatus moschatus) and a ~21,000-year-old ancient individual from Siberia. We found that the muskox' demographic history was profoundly shaped by past climate changes and post-glacial re-colonizations. In particular, the white-faced muskox has the lowest genome-wide heterozygosity recorded in an ungulate. Yet, there is no evidence of inbreeding depression in native muskox populations. We hypothesize that this can be explained by the effect of long-term gradual population declines that allowed for purging of strongly deleterious mutations. This study provides insights into how species with a history of population bottlenecks, small population sizes and low genetic diversity survive against all odds.

AB - Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox (Ovibos moschatus), an Ice Age relict that was at the brink of extinction for thousands of years at the end of the Pleistocene yet appears to be thriving today. We analysed 108 whole genomes, including present-day individuals representing the current native range of both muskox subspecies, the white-faced and the barren-ground muskox (O. moschatus wardi and O. moschatus moschatus) and a ~21,000-year-old ancient individual from Siberia. We found that the muskox' demographic history was profoundly shaped by past climate changes and post-glacial re-colonizations. In particular, the white-faced muskox has the lowest genome-wide heterozygosity recorded in an ungulate. Yet, there is no evidence of inbreeding depression in native muskox populations. We hypothesize that this can be explained by the effect of long-term gradual population declines that allowed for purging of strongly deleterious mutations. This study provides insights into how species with a history of population bottlenecks, small population sizes and low genetic diversity survive against all odds.

KW - ancient DNA

KW - genetic diversity

KW - genetic load

KW - inbreeding

KW - muskox

KW - population genomics

U2 - 10.1111/mec.17205

DO - 10.1111/mec.17205

M3 - Journal article

C2 - 37971141

AN - SCOPUS:85176923803

VL - 33

JO - Molecular Ecology

JF - Molecular Ecology

SN - 0962-1083

IS - 2

ER -

ID: 374402853